Middle Ear Disorders

The diagnostic utility of static immittance (SI) with respect to distinguishing healthy from otosclerotic ears was investigated at different probe-tone frequencies in 68 healthy ears and 36 ears with surgically confirmed otosclerosis. Because one effect of otosclerosis is to shift the resonant frequency of the middle ear to higher values as a result of increased stiffness of the middle ear system, it was hypothesized that SI measured at higher probe-tone frequencies may provide a better distinction between healthy and otosclerotic ears. As expected, the results of this study indicate that SI measured at higher probe-tone frequencies is superior to a standard low probe tone in the detection of otosclerotic ears. Through systematic and objective comparisons of relevant probe-tone frequencies using both group statistics and test performance analysis, the present study suggests 630 Hz as an optimum probe-tone frequency for measuring SI with respect to distinguishing healthy ears from otosclerotic ears.

show abstract

Possible Neuronal Refractory or Recovery Artifacts Associated with Recording the Mismatch Negativity Response

Walker

Carpenter

Downs

et al. 2001

J Am Acad Audiol

View full text Add to dashboard Cite

The mismatch negativity (MMN) is an event-related potential that involves a negative voltage shift of baseline electroencephalographic (EEG) activity in the approximate latency window of the N, and P2 cortical potentials in response to new or novel sounds. The MMN is present at birth and has been hypothesized to serve as an automatic preconscious detector of changes in the auditory environment. Research paradigms used to extract the MMN response from EEG activity have a potential problem related to neuronal refractoriness or recovery. Both N1 and P2 are known to increase in amplitude with longer interstimulus intervals (ISIs). The MMN extraction procedures involve mathematical subtraction of waveforms elicited by standard sounds (with short ISIs) from those recorded to rare deviant sounds (with longer ISIs). Any ISI-dependent amplitude changes in N, and/or P2 could therefore alter the morphology of the resulting difference wave and lead to misinterpretation of the nature of the underlying MMN generators. We tested 12 young females and found that the MMN can be influenced by ISI-dependent refractory effects that may modify the waveform morphology. This has important clinical implications since the MMN is being investigated as an assessment tool. Abbreviations: ANOVA = analysis of variance, CNS = central nervous system, EEG = electroencephalographic, ERP = event-related potential, ISI = interstimulus interval, LAEP = late auditory evoked potential, MMN = mismatch negativity

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Middle Ear Disorders

Cited by 3 publications

References 44 publications

Erratum to: Conductive Hearing Loss Induced by Experimental Middle-Ear Effusion in a Chinchilla Model Reveals Impaired Tympanic Membrane-Coupled Ossicular Chain Movement

Erratum to: Conductive Hearing Loss Induced by Experimental Middle-Ear Effusion in a Chinchilla Model Reveals Impaired Tympanic Membrane-Coupled Ossicular Chain Movement

Distinguishing Healthy from Otosclerotic Ears: Effect of Probe-Tone Frequency on Static Immittance

Possible Neuronal Refractory or Recovery Artifacts Associated with Recording the Mismatch Negativity Response

Contact Info

Product

Resources

About