Cleft lip and/or cleft palate (CLP) are common developmental anomalies. [1] In general, the worldwide incidence of clefts is estimated to be between 1 and 2.21 cases per 1000 live births. [1] In most cases, CLP occurs as an isolated anomaly. However, the association of CLP with genetic syndromes, the so-called syndromic cleft lip and palate (SCLP), has been described previously in the seventies. [2] At that time, only 154 cleft-related syndromes were known in contrast to the well over 500 syndromes recognized in the literature today. [3] SCLP patients represent between 10% and 30% of CLP cases, according to past and current publications. [3][4][5] The aim of this clinical study was to identify syndromic cleft patients and evaluate how their genetic syndrome influenced the timing of the algorithm in the treatment of CLP. The study was conducted on patients managed by the Pécs Cleft Team (PCT) between January 1999 and December 2015.
MethodsA study of nonsyndromic and syndromic cleft patients managed and followed by the PCT was conducted over the 16 years between January 1999 and December 2015. Detailed clinical documentation of all patients, including genetic and epidemiological data, was required for inclusion in the study. The data were collected retrospectively without personal identifying details. At the time of the data collection, permission from the regional ethical committee was not deemed to be obligatory because of the retrospective nature of the study. Special permission was obtained and granted for data collection from the Hungarian Congenital Abnormality Registry (HCAR). The