Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study

Reusken, Chantal; Haagmans, Bart L.; Müller, Marcel A.; Gutiérrez, Carlos; Godeke, Gert Jan; Meyer, Benjamin; Muth, Doreen; Raj, V. Stalin; Vries, L.S. de; Corman, Victor M.; Drexler, Jan Felix; Smits, Saskia L.; Tahir, Yasmin El; Sousa, Rita de; Beek, Janko van; Nowotny, Norbert; Maanen, Kees van; Hidalgo-Hermoso, Ezequiel; Bosch, Berend Jan; Rottier, Peter J. M.; Osterhaus, Albert D. M. E.; Gortázar-Schmidt, Christian; Drosten, Christian; Koopmans, Marion

doi:10.1016/s1473-3099(13)70164-6

Cited by 668 publications

(735 citation statements)

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“…The serum samples were tested for the presence of IgG antibodies reactive with S1 antigens against MERS-CoV (residues 1-747), severe acute respiratory syndrome CoV (residues 1-676), and human CoV OC43 (residues 1-760) by using extensively validated protein-microarray technology, as described (2,3,6,11). Results were expressed as relative mean fluorescent intensity (RFU) for each set of quadruplicate spots of antigen, with a cutoff of 4,000 RFU as used by Meyer et al (6).…”

Section: The Studymentioning

confidence: 99%

“…In August 2013, dromedary camels (Camelus dromedarius) were implicated for the first time as a possible source for human infection on the basis of the presence of MERS-CoV neutralizing antibodies in dromedaries from Oman and the Canary Islands of Spain (2). Since then, the presence of MERS-CoV antibodies in dromedaries has been reported in Jordan (3), Egypt (4,5), the United Arab Emirates (6,7), and Saudi Arabia (8,9).…”

mentioning

confidence: 99%

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Geographic Distribution of MERS Coronavirus among Dromedary Camels, Africa

Reusken¹,

Messadi²,

Feyisa³

et al. 2014

Emerg. Infect. Dis.

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Section: The Studymentioning

confidence: 99%

mentioning

confidence: 99%

Geographic Distribution of MERS Coronavirus among Dromedary Camels, Africa

Reusken¹,

Messadi²,

Feyisa³

et al. 2014

Emerg. Infect. Dis.

Self Cite

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“…There is growing evidences that the dromedary camel is host species for MERS-CoV and plays an important role in the transmission of the viruses to human (15)(16)(17)(18)(19)(20). In August 2013, for the first time, dromedary camels were implicated as a possible source of virus causing human infection because of the presences of MERS-CoV specific neutralizing antibodies in dromedary camels from Oman and other countries in the Arabian Peninsula and North Africa (15)(16)(17)(18)(19). An analysis of an outbreak of MERS-CoV infection in humans in Qatar in October 2013 found that dromedary camels and humans were infected with a nearly identical strain of MERS-CoV (18).…”

Section: Sources Of Infection and Transmission Routesmentioning

confidence: 99%

“…An analysis of an outbreak of MERS-CoV infection in humans in Qatar in October 2013 found that dromedary camels and humans were infected with a nearly identical strain of MERS-CoV (18). Further studies from Saudi Arabia supported the hypothesis that dromedary camels act as reservoirs of MERS-CoV (17,19). Widespread circulation of different genetic variants of MERS-CoV has been found in camels and the presence of MERS-CoV specific antibodies in samples taken from camels, years earlier.…”

Section: Sources Of Infection and Transmission Routesmentioning

confidence: 99%

Middle East Respiratory Syndrome Coronavirus: A Review

Sarparast¹,

Saffar²

2015

J Pediatr Rev

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Context: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection is an emerging human disease that has been reported from the Arabian Peninsula and Middle East countries since 2012. Although zoonotic transmission was postulated, virological and serological finding suggest that the dromedary camels act as the potential reservoirs of MERS-CoV infection to humans. As October 2014, a totally 855 confirmed cases with 333 related deaths were reported to WHO. All cases occurred in or epidemiologically linked to affected countries. The virus ability to induce a pandemic attack is limited. The clinical presentations vary and range from asymptomatic infection to severe respiratory disease and death. However, most severe disease occurs in elderly and in those with underlying conditions. Infection prevention and control measures are critical to prevent the possible spread of MERS-CoV infection is health care facilities and in the community. The WHO encourages all member states to perform surveillance of patients with acute severe respiratory infection and to carefully monitor any unusual patterns. This paper aims to review the current key characteristics of MERS-CoV infection in human and update the WHO recommendations about this illness.

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“…With a significant representation of more than 75% of the newly emerging diseases, viral zoonoses are among the top challenges threaten public health. While all known arthropod-borne viruses (arboviruses) are zoonotic pathogens, several arthropod vectors and Animal species including birds, goats, sheep, cattle, camels and wildlife fauna are claimed to be either definite hosts [1], reservoirs or carriers [2][3][4][5], for viral zoonoses.…”

Section: Introductionmentioning

confidence: 99%