New mineralogical, thermobarometric, isotopic, and geochemical data provide evidence for long and complex formation history of the Sarylakh and Sentachan Au-Sb deposits conditioned by regional geo dynamics and various types of ore mineralization, differing in age and source of ore matter combined in the same ore localizing structural units. The deposits are situated in the Taryn metallogenic zone of the East Yakutian metallogenic belt in the central Verkhoyansk-Kolyma Fold Region. They are controlled by the regional Adycha-Taryn Fault Zone that separates the Kular-Nera Terrane and the western part of the Verkhoyansk Fold-Thrust Belt. The fault extends along the strike of the northwest trending linear folds and is deep rooted and repeatedly reactivated. The orebodies are mineralized crush zones accompanied by sulfi dated (up to 100 m wide) quartz-sericite metasomatic rocks and replacing dickite-pyrophyllite alteration near stibnite veinlets. Two stages of low sulfide gold-quartz and stibnite mineralization are distinguished. The formation conditions of the early milk white quartz in orebodies with stibnite mineralization at the Sary lakh and Sentachan deposits are similar: temperature interval 340-280°C, salt concentration in fluids 6.8-1.6 wt % NaCl equiv, fluid pressure 3430-1050 bar, and sodic bicarbonate fluid composition. The ranges of fluid salinity overlapped at both deposits. In the late regenerated quartz that attends stibnite mineralization, fluid inclusions contain an aqueous solution with salinity of 3.2 wt % NaCl equiv and are homogenized into liquid at 304-189°C. Syngenetic gas inclusions contain nitrogen 0.19 g/cm 3 in density. The pressure of 300 bar is estimated at 189°C. The composition of the captured fluid is characterized as K-Ca bicarbonatesulfate. The sulfur isotopic composition has been analyzed in pyrite and arsenopyrite from ore and metaso matic zones, as well as in coarse , medium , and fine grained stibnite varieties subjected to dynamometa morphism. The following δ 34 S values, ‰ have been established at the Sarylakh deposit: -2.0 to -0.9 in arse nopyrite, -5.5 to -1.1 in pyrite, and -5.5 to -3.6 in stibnite. At the Sentachan deposit: -0.8 to +1.0 in arse nopyrite, +0.5 to +2.6 in pyrite, and -3.9 to +0.6 in stibnite. Sulfides from the Sentachan deposit is somewhat enriched in 34 S. The 18 O of milk white quartz at the Sarylakh deposit varies from +14.8 to 17.0‰ and from +16.4 to + 19.3‰ at the Sentachan. The δ 18 O of regenerated quartz is +16.5‰ at the Sarylakh and +17.6 to +19.8‰ at the Sentachan. The δ 18 O of carbonates varies from +15.0 to 16.3% at the Sarylakh and from +16.7 to +18.2‰ at the Sentachan. The δ 13 C of carbonates ranges from -9.5 to -12.1‰ and -7.8 to -8.5‰, respectively. The calculated δ 18 O H 2 O of the early fluid in equilibrium with quartz and dolomite at 300°C are +7.9 to +10.1‰ for the Sarylakh deposit and +9.5 to +12.4‰ for the Sentachan deposit (+4.9 and 6.0‰ at 200°C for the late fluid, respectively). Most estimates fall into the interval characteristic o...