Middle term results of tantalum acetabular cups in total hip arthroplasty following pelvic irradiation

Zucchini, Riccardo; Romagnoli, Carlo; Romantini, Matteo; Mariotti, Federica; Donati, Davide María

doi:10.1016/j.aott.2019.03.007

Cited by 15 publications

(28 citation statements)

References 18 publications

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“…In addition, porous Ta acetabular implants and augmentations were suggested in the reconstruction of the hip joint after resection of peri-acetabular tumors, in order to ensure satisfactory clinical results at early stage [ 96 ]. The irradiated pelvis was reported to always be associated with high aseptic loosening rates of acetabular components [ 97 , 98 , 99 ]. Even so, porous Ta cups still obtained satisfactory results in THA treatment of irradiated pelvis owing to their high friction coefficient and porous microstructure, as well as rapid bone ingrowth rate [ 97 , 98 , 99 ].…”

Section: Clinical Application Of Porous Ta In Orthopedics and Dentistrymentioning

confidence: 99%

“…The irradiated pelvis was reported to always be associated with high aseptic loosening rates of acetabular components [ 97 , 98 , 99 ]. Even so, porous Ta cups still obtained satisfactory results in THA treatment of irradiated pelvis owing to their high friction coefficient and porous microstructure, as well as rapid bone ingrowth rate [ 97 , 98 , 99 ]. However, it is imperative to note that transverse acetabulum fracture may occur during or after the revision surgery if excessive reaming is performed to insert large cups (average 58 mm) during the operation [ 100 , 101 ].…”

Section: Clinical Application Of Porous Ta In Orthopedics and Dentistrymentioning

confidence: 99%

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The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

2021

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Porous tantalum (Ta) is a promising biomaterial and has been applied in orthopedics and dentistry for nearly two decades. The high porosity and interconnected pore structure of porous Ta promise fine bone ingrowth and new bone formation within the inner space, which further guarantee rapid osteointegration and bone–implant stability in the long term. Porous Ta has high wettability and surface energy that can facilitate adherence, proliferation and mineralization of osteoblasts. Meanwhile, the low elastic modulus and high friction coefficient of porous Ta allow it to effectively avoid the stress shield effect, minimize marginal bone loss and ensure primary stability. Accordingly, the satisfactory clinical application of porous Ta-based implants or prostheses is mainly derived from its excellent biological and mechanical properties. With the advent of additive manufacturing, personalized porous Ta-based implants or prostheses have shown their clinical value in the treatment of individual patients who need specially designed implants or prosthesis. In addition, many modification methods have been introduced to enhance the bioactivity and antibacterial property of porous Ta with promising in vitro and in vivo research results. In any case, choosing suitable patients is of great importance to guarantee surgical success after porous Ta insertion.

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Section: Clinical Application Of Porous Ta In Orthopedics and Dentistrymentioning

confidence: 99%

Section: Clinical Application Of Porous Ta In Orthopedics and Dentistrymentioning

confidence: 99%

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

2021

View full text Add to dashboard Cite

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“…In addition, porous Ta acetabular implants and augments were suggested in the reconstruction of hip joint after resection of peri-acetabular tumors for their satisfactory clinical results at early stage [82]. The irradiated pelvis was reported to be always associated with high aseptic loosening rate of acetabular components [83][84][85]. Even so, porous Ta cups still obtained satisfactory results in THA treatment of irradiated pelvis owing to their high friction coefficient and porous microstructure, as well as rapid bone in-growth rate [83][84][85].…”

Section: Hip Arthroplastymentioning

confidence: 99%

“…The irradiated pelvis was reported to be always associated with high aseptic loosening rate of acetabular components [83][84][85]. Even so, porous Ta cups still obtained satisfactory results in THA treatment of irradiated pelvis owing to their high friction coefficient and porous microstructure, as well as rapid bone in-growth rate [83][84][85]. However, it is imperative to note that transverse acetabulum fracture may occur during or after the revision surgery if excessive reaming is performed so as to insert large cups (average 58 mm) in the operation [86,87].…”

Section: Hip Arthroplastymentioning

confidence: 99%

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

Huang¹,

Pan²,

Qiu³

2021

Preprint

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Porous tantalum (Ta) is a promising biomaterial and has been applied in orthopedics and dentistry for nearly two decades. The high porosity and interconnected pore structure of porous Ta promise fine bone ingrowth and new bone formation within the inner space, which further guarantee rapid osteointegration and bone-implant stability in long term. Porous Ta has high wettability and surface energy that can facilitate adherence, proliferation and mineralization of osteoblasts. Meanwhile, low elastic modulus and high friction coefficient of porous Ta can effectively avoid stress shield effect, minimize marginal bone loss and ensure primary stability. Accordingly, the satisfactory clinical application of porous Ta based implants or prostheses are mainly derived from its excellent biological and mechanical properties. With the advent of additive manufacturing, personalized porous Ta based implants or prostheses have shown their clinical value in the treatment of individual patient who need specially designed implant or prosthesis. In addition, many modification methods have been introduced to enhance the bioactivity and antibacterial property of porous Ta with promising in vitro and in vivo research results. In any case, choosing suitable patients is of great importance to guarantee surgical success after porous Ta insertion.

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“… 11 Increased complication rates after total hip replacement of irradiated hips have been reported. 6 , 12 …”

Section: Introductionmentioning

confidence: 99%

Long-Term Risk of Hip Complications After Radiation Therapy for Prostate Cancer: A Dose-Response Study

Rasmusson

Nilsson

Kjellén

et al. 2021

Advances in Radiation Oncology

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Purpose The aim of the present study was to analyze the long-term incidence of hip complications after external beam radiation therapy compared with age-matched controls from the general population. We also investigated whether there were any dose−response associations. Methods and materials A total of 349 patients with prostate cancer treated to curative dose with external beam radiation therapy between 1997 and 2002 were included in the study. Physical and fractionation-corrected dose-volume descriptors were derived for the femoral heads, pubic bone, and sacrum. Information on skeletal events was collected for the patients and 1661 matched controls through the Prostate Cancer database Sweden. Uni- and multivariable Cox proportional hazard regressions were used to analyze the time to event. Results Data from 346 patients were available for analysis. The median mean physical dose and corresponding equivalent 2-Gy/fraction dose (EQD2) to the femoral heads were 35.5 Gy and 28.7 Gy, respectively. The median follow-up time was 16.0 years. During the follow up, 12 hip fractures occurred. Hip osteoarthritis was diagnosed in 36 cases, with 29 cases leading to replacement surgery. No increased risk of hip fractures was found. Hip osteoarthritis was the only event for which a statistically significant difference was found between the irradiated cohort and the controls (cause-specific hazard ratio: 1.56; 95% confidence interval, 1.07-2.26; P = .02). The cumulative incidence of osteoarthritis at 10 years was 8.1% and 4.9% in the irradiated cohort and the controls, respectively. A significant relationship between osteoarthritis and the volume of the femoral head receiving ≥40 Gy (ie, EQD2) was found. Conclusions In this study of 346 patients treated with conventional radiation therapy, we found no increased risk of hip fracture but an increased risk of clinically relevant osteoarthritis at long-term follow up. Our results indicate a dose–response relationship between osteoarthritis and the volume of the femoral head receiving an EQD2 dose of ≥40 Gy.

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Middle term results of tantalum acetabular cups in total hip arthroplasty following pelvic irradiation

Cited by 15 publications

References 18 publications

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

Long-Term Risk of Hip Complications After Radiation Therapy for Prostate Cancer: A Dose-Response Study

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