Midface endoprosthetics with superelastic porous niti implants

Arsenova, I.A.; Sysolyatin, P. G.; Gunther, V.E.

doi:10.1016/s0901-5027(05)80941-5

Cited by 4 publications

(3 citation statements)

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“…The second trial corresponds to the midface endoprosthetic area. PNT constructs were used in the midface reconstruction in 129 patients with encouraging results [ 172 ]. However, continued follow-up is necessary to determine the clinical long-term success of these PNT constructs.…”

Section: Biocompatibility Of Commercially Available Metallic Scaffmentioning

confidence: 99%

Metallic Scaffolds for Bone Regeneration

2009

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Bone tissue engineering is an emerging interdisciplinary field in Science, combining expertise in medicine, material science and biomechanics. Hard tissue engineering research is focused mainly in two areas, osteo and dental clinical applications. There is a lot of exciting research being performed worldwide in developing novel scaffolds for tissue engineering. Although, nowadays the majority of the research effort is in the development of scaffolds for non-load bearing applications, primarily using soft natural or synthetic polymers or natural scaffolds for soft tissue engineering; metallic scaffolds aimed for hard tissue engineering have been also the subject of in vitro and in vivo research and industrial development. In this article, descriptions of the different manufacturing technologies available to fabricate metallic scaffolds and a compilation of the reported biocompatibility of the currently developed metallic scaffolds have been performed. Finally, we highlight the positive aspects and the remaining problems that will drive future research in metallic constructs aimed for the reconstruction and repair of bone.

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Section: Biocompatibility Of Commercially Available Metallic Scaffmentioning

confidence: 99%

Metallic Scaffolds for Bone Regeneration

2009

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“…They reported that the cages provided support in the necrotic femoral head. Arsenova, et al [145] implanted porous Nitinol scaffold saturated with bone marrow into patients with endoprosthetic bone defects and reported good integration.…”

Section: Nickel-titanium Alloy (Nitinol)mentioning

confidence: 99%

Biomechanics of Additively Manufactured Metallic Scaffolds—A Review

et al. 2021

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This review paper is related to the biomechanics of additively manufactured (AM) metallic scaffolds, in particular titanium alloy Ti6Al4V scaffolds. This is because Ti6Al4V has been identified as an ideal candidate for AM metallic scaffolds. The factors that affect the scaffold technology are the design, the material used to build the scaffold, and the fabrication process. This review paper includes thus a discussion on the design of Ti6A4V scaffolds in relation to how their behavior is affected by their cell shapes and porosities. This is followed by a discussion on the post treatment and mechanical characterization including in-vitro and in-vivo biomechanical studies. A review and discussion are also presented on the ongoing efforts to develop predictive tools to derive the relationships between structure, processing, properties and performance of powder-bed additive manufacturing of metals. This is a challenge when developing process computational models because the problem involves multi-physics and is of multi-scale in nature. Advantages, limitations, and future trends in AM scaffolds are finally discussed. AM is considered at the forefront of Industry 4.0, the fourth industrial revolution. The market of scaffold technology will continue to boom because of the high demand for human tissue repair.

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“…It is necessary to study the tissue response of bone substitutes. Broadening the understanding of the complex cell/material interactions will contribute to the development of novel biomaterials since tissue-engineered constructs that direct biological responses [10,11].…”

Section: Introductionmentioning

confidence: 99%

Techniques to Study Cellular Response in Critical Size Bone Defect Healing on Rat Calvaria Treated with Hydroxyapatite Implants

Costa

Melo

Brito

et al. 2008

KEM

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The aim of this paper was to evaluate the usefulness of coupling digital image analysis with immunohistochemistry and histomorphometry data to the study of tissue response to hydroxyapatite in a model of critical size bone defect in calvaria of rats. A transosseous defect measuring 8 mm in diameter was performed with a surgical trephine in the parietal bone of 40 rats and divided into two experimental groups according to the treatment: group I (blood clot, control), group II (HA) and killed 1, 3, 6 and 9 months after implantation (n=5/group/period). The skullcaps with overlaying skin were collected and processed for paraffin embedding. The specimens were cut in the laterolateral direction into 5-µm thick semi-serial sections and stained with hematoxylin-eosin for identification and counting of polymorphonuclears cells, mastocytes, and multinucleated giant cells, MNG, or immunolabeled with anti- lysozyme, -factor VIII and –PCNA. Digital images were obtained and analyzed with the ImagePro-Plus® software for cell couting (polymorphonuclears cells, mastocytes, macrophages and MNG) and microvessel density. Image segmentation of anti-PCNA immunostaining was used for cell proliferation analysis. The digital images obtained allowed clear identification of cells of interest by through morphological aspects or immunostaining. Data recording and analysis was facilitated by the use of specific software for image processing and graphical and statistical analysis. It can be concluded that the techniques applied were usefull to identify and count cells, structures and process of interest making easier the effectiveness of hydroxyapatite in the critical size defect in rat calvaria model.

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Midface endoprosthetics with superelastic porous niti implants

Cited by 4 publications

References 0 publications

Metallic Scaffolds for Bone Regeneration

Metallic Scaffolds for Bone Regeneration

Biomechanics of Additively Manufactured Metallic Scaffolds—A Review

Techniques to Study Cellular Response in Critical Size Bone Defect Healing on Rat Calvaria Treated with Hydroxyapatite Implants

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