Midgestational excisional fetal lamb wounds contract in utero

Longaker, Michael T.; Burd, D. Andrew R.; Gown, Allen M.; Yen, T. S. Benedict; Jennings, Russell W.; Duncan, Brian W.; Harrison, Michael R.; Adzick, N. Scott

doi:10.1016/0022-3468(91)90841-g

Cited by 39 publications

(11 citation statements)

References 17 publications

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“…88 ORGAN REGENERATION role in modulation of the transition from early fetal healing, which is scarless, to late fetal healing, which occurs with scar formation. 29,36,76,77 This finding is consistent with the observation that the emergence of contraction as a wound closure mechanism accompanies the transition from early to late fetal healing. It is well known that the myofibroblast dominates contraction and that TGF-b1 is required for the expression of the contractile phenotype in fibroblasts.…”

Section: Summary Of Mechanistic Differences Between Early Fetal Healisupporting

confidence: 89%

Early Fetal Healing as a Model for Adult Organ Regeneration

2007

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Section: Summary Of Mechanistic Differences Between Early Fetal Healisupporting

confidence: 89%

Early Fetal Healing as a Model for Adult Organ Regeneration

2007

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“…Silicone sheeting was used to cover skin wounds and to isolate them from amniotic fluid in these studies. Authors who utilized the same model reported various results as to whether amniotic fluid displayed a suppressive or an augmentative effect on fetal tissue inflammation [25,27,33]. As no significant difference was detected between the groups, it was concluded that amniotic fluid had no potential effects on soft tissue inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…In fetal tissue, fibroblasts are known to be better regulated and excess collagen production is avoided [11,20,23]. The effects of amniotic fluid on fetal fibroblasts was studied in a number of experiments [7,18,25,27]. In the present study, we only attempted to detect the presence of fibroblastic cells.…”

Section: Discussionmentioning

confidence: 99%

Histologic effects of amniotic fluid in the early phases of bone healing: an experimental study on rabbits

Lu¹,

Keçik

Çelik

et al. 2000

E J Plastic Surg

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The purpose of this study was to demonstrate the histological effects of amniotic fluid on bone healing in the rabbit fetus. Fetal femurs (n=34) were fractured in the diaphysis and two experimental groups were established. In group A fetuses (n=18), the fracture ends were bathed in amniotic fluid through their unsutured skin wounds. In group B fetuses (n=16), the fracture sites were isolated from amniotic fluid by suturing the wound edges. Nonoperated fetuses were used as control group (n=9). The fetuses were sacrificed on the first, third and seventh postoperative days for histological studies. Histological examination of the specimens was performed to detect inflammation, fibroblastic proliferation, bone cellularity, callus and cartilage formation. The results were compared, using the Fisher exact chi square test criteria, where no statistically significant differences were detected between group A and group B ( P>0.05). Materials and methodsThis study was performed on 74 fetuses of 30 pregnant albino New Zealand rabbits of 3-5 kg. Sixty-five fetuses were operated on, but 37 fetuses survived, three fetuses were excluded from the study and the remaining 34 formed the experimental group, while nine nonoperated fetuses were the control group.A. Kayıkçıoḡlu ( ✉ ) 38 Sokak 4/4,

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“…Some studies also addressed the impact of amniotic fluid, which is sterile and rich in growth factors [50]. Its role was not definitely determined; nevertheless, its advantageous influence was confirmed solely in the early pregnancy stage [51,52]. It was suggested that amniotic fluid is responsible for provision of unique conditions for healing, regardless of the properties of the injured tissue [50].…”

Section: Plastic Surgerymentioning

confidence: 99%

In utero surgery – current state of the art – part II

Wójcicki

Drozdowski²

2011

Med Sci Monit

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SummaryBackgroundFetal surgery, also referred to as in utero, prenatal or intrauterine surgery, consists of treatment of congenital malformations during the fetal period. The idea of treating malformations diagnosed in the course of intrauterine life dates back to 1963, when Lilly performed the first blood transfusion in a fetus. Since then it has been introduced as a treatment option in a series of lethal malformations. Efforts are being made to treat nonlethal malformations by means of fetal surgery.Material/MethodsA comprehensive search of the literature using MEDLINE and PubMed between 1925 and February 2009 was performed. Search terms for MEDLINE and PubMed were: fetal surgery, foetal surgery, in utero surgery, prenatal surgery, and in utero treatment. In addition, information was obtained at Web sites of the International Medicine and Surgery Society and the University of California Fetal Treatment Centre.ResultsAuthors’ attention focused on the survey of indications to intrauterine operations. We outline potential directions of its development, quoting the groundwork of the most experienced researchers and clinicians. Moreover, owing to the authors’ interest in plastic surgery, some remarks on the role of intrauterine medicine and surgery in this branch of medicine are made.ConclusionsIn utero surgery may be regarded as an efficient tool of preventive medicine. It offers some advantages that no other branch of medicine may offer. However, its implementation is more troublesome than in the past, therefore only selected cases may benefit from its advantages. Nevertheless, current tendencies are to include, after thorough evaluation of benefit-risk ratio, some new indications for fetal surgery.

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Midgestational excisional fetal lamb wounds contract in utero

Cited by 39 publications

References 17 publications

Early Fetal Healing as a Model for Adult Organ Regeneration

Early Fetal Healing as a Model for Adult Organ Regeneration

Histologic effects of amniotic fluid in the early phases of bone healing: an experimental study on rabbits

In utero surgery – current state of the art – part II

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