Midlife Sleep Characteristics Associated with Late Life Cognitive Function

Virta, Jyri J.; Heikkilä, Kauko; Perola, Markus; Koskenvuo, Markku; Räihä, Ismo; Rinne, Juha O.; Kaprio, Jaakko

doi:10.5665/sleep.3052

Cited by 144 publications

(133 citation statements)

References 34 publications

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“…Three studies reported that decreased sleep duration over time was associated with lower cognitive function [61,68,73] , and 4 studies found that increased sleep duration was related to worse cognition [59,61,68,73] . One of these studies included prospective data on cognitive function, enabling analyses of changes in sleep duration with cognitive decline; however, there was no indication of association in these results [73] .…”

Section: Results Of Studies On Change In Sleep Duration and Cognitivementioning

confidence: 99%

“…A minority of studies in this review considered sleep-related variables other than sleep duration (i.e. sleep quality, sleep medication use, and sleep-disordered breathing) as part of their statistical analyses, but one study did find that results were attenuated with adjustment for self-reported sleep quality [68] . This is consistent with two other studies included in our review that indicated objective measures of sleep disturbances, but not sleep duration, were related to worse cognitive outcomes in older adults [55,75] ; additional literature also supports a link between poor sleep quality and lower cognition in later life [24] .…”

Section: Discussionmentioning

confidence: 99%

“…Most studies involved cross-sectional analyses of exposure and outcome data collected at the same time point, although two studies reported on midlife sleep duration assessed 1-2 decades prior to cognitive function testing [68,73] . There were a limited number of prospective studies, with repeated cognitive assessments conducted over varying follow-up periods; however, these studies more often indicated an association between extreme sleep duration and poor cognitive function.…”

Section: Discussionmentioning

confidence: 99%

“…These studies ranged in size from 26 to 32,142 participants, and were conducted across multiple countries: United States [53, 55-57, 67, 70, 72, 73, 75, 79] , United Kingdom [61,64,77] , Spain [58,69] , Finland [50,68] , France [54,62] , Japan [65,78] , Australia [52] , Germany [59] , Ireland [16] , Netherlands [80] , Hong Kong [66] , Canada [63] , Korea [60] , China [76] , Singapore [71] . There was also a multi-country study incorporating data from China, Ghana, India, South Africa, Russia, and Mexico [74] ; the location of one study was unknown [51] .…”

Section: Description Of Studies Included In Our Reviewmentioning

confidence: 99%

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Sleep Duration in Relation to Cognitive Function among Older Adults: A Systematic Review of Observational Studies

2016

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Context: Increasing evidence suggests that circadian and sleep parameters influence cognitive function with aging. Objective: To evaluate observational studies of sleep duration and cognition in older adults. Data Sources: A systematic review of OVID Medline and PsycINFO through September 2015, and review of bibliographies from studies identified. Study Selection: English-language articles reporting observational studies of sleep duration and cognitive function in older populations. Data Extraction: Data extraction by 2 authors using predefined categories of desired information. Results: Thirty-two studies met our inclusion criteria, with nearly two-thirds published in the past 4 years. One-third of studies indicated that extreme sleep durations were associated with worse cognition in older adults. More studies favored an association with long vs. short sleep durations (35 vs. 26% of studies, respectively). Four studies found that greater changes in sleep duration over time were related to lower cognition. Study design and analytic methods were very heterogeneous across studies; therefore, meta-analysis was not undertaken. Limitations: We reviewed English-language manuscripts only, with a qualitative summary of studies identified. Conclusions and Implications of Key Findings: Observational studies of sleep duration and cognitive function in older adults have produced mixed results, with more studies suggesting that long (rather than short) sleep durations are related to worse cognition. Studies more consistently indicate that greater changes in sleep duration are associated with poor cognition. Future studies should be prospectively designed, with objective sleep assessment and longer follow-up periods; intervention studies are also needed to identify strategies for promoting cognitive health with aging.

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Section: Results Of Studies On Change In Sleep Duration and Cognitivementioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Description Of Studies Included In Our Reviewmentioning

confidence: 99%

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Sleep Duration in Relation to Cognitive Function among Older Adults: A Systematic Review of Observational Studies

2016

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“…1 Chronic insomnia, prolonged daytime sleepiness, and long sleeping have been associated with poorer cognitive function. [2][3][4][5][6] However, the contribution of sleep problems to the risk of dementia is poorly understood. Only 2 groups have examined this association.…”

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confidence: 99%

Long sleep duration in elders without dementia increases risk of dementia mortality (NEDICES)

et al. 2014

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Objective: To determine in a population-based study whether long sleep duration was associated with increased risk of dementia mortality. Methods:In this prospective, population-based study of 3,857 people without dementia aged 65 years and older (NEDICES [Neurological Disorders in Central Spain]), participants reported their daily sleep duration. The average daily total sleep duration was grouped into 3 categories: #5 hours (short sleepers), 6-8 hours (reference category), and $9 hours (long sleepers). Communitydwelling elders were followed for a median of 12.5 years, after which the death certificates of those who died were examined.Results: A total of 1,822 (47.2%) of 3,857 participants died, including 201 (11.0%) deaths among short sleepers, 832 (45.7%) among long sleepers, and 789 (43.3%) among those participants in the reference category. Of 1,822 deceased participants, 92 (5.1%) had a dementia condition reported on the death certificate (49 [53.3%] were long sleepers, 36 [39.1%] reported sleeping between 6 and 8 hours, and 7 [7.6%] were short sleepers). In an unadjusted Cox model, risk of dementia-specific mortality was increased in long sleepers (hazard ratio for dementia mortality in long sleepers 5 1.58, p 5 0.04) when compared with the reference group. In a Cox model that adjusted for numerous demographic factors and comorbidities, the hazard ratio for dementia mortality in long sleepers was 1.63 (p 5 0.03).Conclusions: Self-reported long sleep duration was associated with 58% increased risk of dementia-specific mortality in this cohort of elders without dementia. Future studies are required to confirm these findings.

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Association Between Sleep Duration and Cognitive Decline

et al. 2020

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Midlife Sleep Characteristics Associated with Late Life Cognitive Function

Abstract: This is the first study indicating that midlife sleep length, sleep quality, and use of hypnotics are associated with late life cognitive function. Further confirmation is needed, but sleep-related characteristics may emerge as new risk factors for cognitive impairment.

Cited by 144 publications

References 34 publications

Sleep Duration in Relation to Cognitive Function among Older Adults: A Systematic Review of Observational Studies

Sleep Duration in Relation to Cognitive Function among Older Adults: A Systematic Review of Observational Studies

Long sleep duration in elders without dementia increases risk of dementia mortality (NEDICES)

Association Between Sleep Duration and Cognitive Decline

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