Midlife Women's Responses to a Hospital Sleep Challenge: Aging and Menopause Effects on Sleep Architecture

Lukacs, Jane L.; Chilimigras, Julie L.; Cannon, Jason R.; Dormire, Sharon; Reame, Nancy E.

doi:10.1089/154099904323016491

Cited by 16 publications

(5 citation statements)

References 30 publications

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“…The objective and subjective sleep quality of premenopausal women was closer to that of postmenopausal women than that of young women. Studies exactly like ours are not available but our results are in line with the results of Lukacs et al 31 whose study was conducted under sleep challenge. 31 We could also reproduce the well-documented age-related sleep changes, such as the worsening of the overall sleep architecture and decline in slow wave sleep, between young women and the older groups.…”

Section: Discussionsupporting

confidence: 93%

“…Studies exactly like ours are not available but our results are in line with the results of Lukacs et al 31 whose study was conducted under sleep challenge. 31 We could also reproduce the well-documented age-related sleep changes, such as the worsening of the overall sleep architecture and decline in slow wave sleep, between young women and the older groups. [32][33][34][35] The young women in our study were using OC.…”

Section: Discussionsupporting

confidence: 93%

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Sleep and the menopause – do postmenopausal women experience worse sleep than premenopausal women?

Kalleinen

Polo‐Kantola

Himanen

et al. 2008

Menopause International

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Objective sleep measures differed significantly between the young and postmenopausal groups. These differences may be more because of the physiology of ageing than the rapid changes across the menopause, since similar sleep characteristics were already present in the premenopausal women. The increase in sleep complaints after menopause was not associated with sleepiness or disturbances in objective sleep quality, mood or cognitive performance.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Sleep and the menopause – do postmenopausal women experience worse sleep than premenopausal women?

Kalleinen

Polo‐Kantola

Himanen

et al. 2008

Menopause International

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“…Moreover, to what extent the unblinded nature of the protocol contributed to the reduction is symptoms is not known. Despite the presence of hot flashes during the study, sleep efficiency, although reduced as expected under the experimental conditions, was similar to that observed in healthy postmenopausal women without hot flashes undergoing a similar protocol [67]. …”

Section: Discussionsupporting

confidence: 69%

Black cohosh has central opioid activity in postmenopausal women

Reame

Lukacs²,

Padmanabhan

et al. 2008

Menopause

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Objective-To test whether black cohosh (BC) exhibits an action on the central endogenous opioid system in postmenopausal women.Design-A mechanistic study conducted in the same individuals of LH pulsatility with a saline/ naloxone (NAL) challenge (n=6) and PET imaging with [ 11 C]carfentanil, a selective μ-opioid receptor radioligand (n= 5), before and after 12 weeks of unblinded treatment with a popular black cohosh daily supplement.Results-Black cohosh treatment for 12 weeks at a standard dose (Remifemin, 40 mg/day) had no effect on spontaneous LH pulsatility or estrogen concentrations. With NAL blockade, there was an unexpected suppression of mean LH pulse frequency (saline vs NAL = 9.0+.6 vs 6.0+.7 pulses/ 16 hrs; p= 0.056), especially during sleep when the mean interpulse interval (IPI) was prolonged by approximately 90 minutes (SAL night IPI = 103± 9 mins vs NAL night IPI = 191± 31min, p = 0.03). There were significant increases in μ-opioid receptor binding potential (BP) in the posterior and subgenual cingulate, temporal and orbitofrontal cortex, thalamus and nucleus accumbens ranging from 10% to 61 % across regions -brain regions involved in emotional and cognitive function. In contrast, BP reductions of lesser magnitude were observed in regions known to be involved in the placebo response (anterior cingulate and anterior insular cortex).Conclusion-Using two different challenge paradigms for the examination of central opioid function, a neuropharmacologic action of black cohosh treatment was demonstrated in postmenopausal women.

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“…Kalleinen et al ( 33 ) studied older versus younger women and reported that sleep efficiency decreases with age and is not associated with decreasing estrogen levels. In contrast, other studies have shown greater difficulty in initiation and maintenance of sleep in postmenopausal woman than in premenopausal women, suggesting that sleep difficulties in middle-aged women are related to a decline in estrogen levels ( 34 , 35 ). Studies that examined the effect of estrogen supplementation on sleep disturbances in postmenopausal women have provided conflicting results.…”

Section: Discussionmentioning

confidence: 68%

Poor sleep in middle-aged women is not associated with menopause per se

Tao

Sun

Shao

et al. 2016

Braz J Med Biol Res

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Whether sleep problems of menopausal women are associated with vasomotor symptoms and/or changes in estrogen levels associated with menopause or age-related changes in sleep architecture is unclear. This study aimed to determine if poor sleep in middle-aged women is correlated with menopause. This study recruited women seeking care for the first time at the menopause outpatient department of our hospital. Inclusion criteria were an age ≥40 years, not taking any medications for menopausal symptoms, and no sleeping problems or depression. Patients were assessed with the Pittsburgh Sleep Quality Index (PSQI), modified Kupperman Index (KI), and Menopause Rating Scale (MRS). A PSQI score of <7 indicated no sleep disorder and ≥7 indicated a sleep disorder. Blood specimens were analyzed for follicle-stimulating hormone and estradiol levels. A total of 244 women were included in the study; 103 (42.2%) were identified as having a sleep disorder and 141 as not having one. In addition, 156 (64%) women were postmenopausal and 88 (36%) were not menopausal. Follicle-stimulating hormone and estradiol levels were similar between the groups. Patients with a sleep disorder had a significantly higher total modified KI score and total MRS score (both, P<0.001) compared with those without a sleep disorder. Correlations of the PSQI total score with the KI and MRS were similar in menopausal and non-menopausal women. These results do not support that menopause per se specifically contributes to sleep problems.

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Midlife Women's Responses to a Hospital Sleep Challenge: Aging and Menopause Effects on Sleep Architecture

Abstract: Aging-related sleep deficits in response to an experimental stressor occur in midlife women prior to menopause.

Cited by 16 publications

References 30 publications

Sleep and the menopause – do postmenopausal women experience worse sleep than premenopausal women?

Sleep and the menopause – do postmenopausal women experience worse sleep than premenopausal women?

Black cohosh has central opioid activity in postmenopausal women

Poor sleep in middle-aged women is not associated with menopause per se

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