Midlife Work-Related Stress Increases Dementia Risk in Later Life: The CAIDE 30-Year Study

Sindi, Shireen; Hagman, Göran; Håkansson, Krister; Kulmala, Jenni; Nilsen, Charlotta; Kåreholt, Ingemar; Soininen, Hilkka; Solomon, Alina; Kivipelto, Miia

doi:10.1093/geronb/gbw043

Cited by 54 publications

(72 citation statements)

References 48 publications

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“…A time window of midlife working stress affects dementia onset has been reported . We found that any high job strain experienced before age 40 increased the risk of T2DM, not after the age of 40.…”

Section: Discussionsupporting

confidence: 46%

Work‐related psychosocial stress and the risk of type 2 diabetes in later life

Pan

Mangialasche

et al. 2017

J Intern Med

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Section: Discussionsupporting

confidence: 46%

Work‐related psychosocial stress and the risk of type 2 diabetes in later life

Pan

Mangialasche

et al. 2017

J Intern Med

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“…An initial study found that higher work-related stress, as indicated by low job control and high job demands, was associated with a higher risk of late-life dementia [60]. However, support for this finding has been mixed in subsequent research [61,62]. …”

Section: Psychosocial Factors and Cognitionmentioning

confidence: 99%

How Does Psychosocial Behavior Contribute to Cognitive Health in Old Age?

Wilson

Bennett

2017

Brain Sciences

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With the aging of the U.S. population, the number of cognitively disabled persons is expected to substantially increase in coming decades, underscoring the urgent need for effective interventions. Here, we review the current evidence linking psychosocial factors to late-life cognitive loss and consider the study design needed to illuminate the biologic bases of the associations. We then examine an ongoing study that includes several of the key design elements, the Rush Memory and Aging Project. In this longitudinal clinical-pathological cohort study, indicators of personality, social connectedness, and psychological well-being were shown to predict late-life cognitive outcomes. Participants who died underwent a uniform neuropathologic examination to quantify common dementia-related pathologies. Some psychosocial indicators were associated with cerebral infarction; some indicators modified the association of neurodegenerative pathologies with cognitive loss; and the association of some indicators with cognitive outcomes appears to be independent of the pathologies traditionally associated with late-life dementia. These findings suggest that psychosocial behavior influences late-life cognitive health through multiple neurobiologic mechanisms. A better understanding of these mechanisms may lead to novel strategies for preserving cognitive health in old age.

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“…Environmental and life-style factors such as stress 5 , diet 6 and physical activity were shown to affect cognition 7 and could also affect the risk of LOAD. Evidence suggests that high fat/high cholesterol diet (HFD) could modify the risk for LOAD.…”

Section: Introductionmentioning

confidence: 99%

Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer’s model mice

Nam

Mounier

Wolfe

et al. 2017

Sci Rep

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We examined the effect of chronic high fat diet (HFD) on amyloid deposition and cognition of 12-months old APP23 mice, and correlated the phenotype to brain transcriptome and lipidome. HFD significantly increased amyloid plaques and worsened cognitive performance compared to mice on normal diet (ND). RNA-seq results revealed that in HFD mice there was an increased expression of genes related to immune response, such as Trem2 and Tyrobp. We found a significant increase of TREM2 immunoreactivity in the cortex in response to HFD, most pronounced in female mice that correlated to the amyloid pathology. Down-regulated by HFD were genes related to neuron projections and synaptic transmission in agreement to the significantly deteriorated neurite morphology and cognition in these mice. To examine the effect of the diet on the brain lipidome, we performed Shotgun Lipidomics. While there was no difference in the total amounts of phospholipids of each class, we revealed that the levels of 24 lipid sub-species in the brain were significantly modulated by HFD. Network visualization of correlated lipids demonstrated overall imbalance with most prominent effect on cardiolipin molecular sub-species. This integrative approach demonstrates that HFD elicits a complex response at molecular, cellular and system levels in the CNS.

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Midlife Work-Related Stress Increases Dementia Risk in Later Life: The CAIDE 30-Year Study

Cited by 54 publications

References 48 publications

Work‐related psychosocial stress and the risk of type 2 diabetes in later life

Work‐related psychosocial stress and the risk of type 2 diabetes in later life

How Does Psychosocial Behavior Contribute to Cognitive Health in Old Age?

Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer’s model mice

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