Midterm Follow-up after Cryopreserved Homograft Replacement in the Aortic Position

Park, Samina; Hwang, Ho Young; Kim, Kyung Hwan; Kim, Ki Bong; Ahn, Hyuk

doi:10.5090/kjtcs.2012.45.1.30

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…Park et al [ 4 ] used homografts for aortic root replacement in 15 patients and for aortic graft interposition in 8. These results were compatible with ours, but use of the homograft was different.…”

Section: Discussionmentioning

confidence: 99%

“…The 30-day mortality rate was 9.1% (n=3) in our patients. Park et al [ 4 ] reported an early mortality rate of 8.7%. The 10-year overall survival rate in our patients was 63.4%±9.5%, and was 59.6% for Park et al [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Homograft implantation has been used for a variety of aortic root and aortic valve diseases. The advantages of using homografts in valve replacement surgery include the excellent hemodynamic profile, good hemostasis, low risk of thromboembolism, and low risk of prosthetic valve infection [ 1 – 4 ]. In particular, the aortic homograft has proven its value in complex aortic root pathology such as endocarditis with abscess formation [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Long-Term Outcomes of Homografts in the Aortic Valve and Root Position: A 20-Year Experience

Kim

Jung

et al. 2016

Korean J Thorac Cardiovasc Surg

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BackgroundThe advantages of using a homograft in valve replacement surgery are the excellent hemodynamic profile, low risk of thromboembolism, and low risk of prosthetic valve infection. The aim of this study was to evaluate the long-term outcomes of homograft implantation in the aortic valve position.MethodsThis is a retrospective study of 33 patients (>20 years old) who underwent aortic valve replacement or root replacement with homografts between April 1995 and May 2015. Valves were collected within 24 hours from explanted hearts of heart transplant recipients (<60 years) and organ donors who were not suitable for heart transplantation. The median follow-up duration was 35.6 months (range, 0 to 168 months).ResultsAortic homografts were used in all patients. The 30-day mortality rate was 9.1%. The 1- and 5-year survival rates were 80.0%±7.3% and 60.8%±10.1%, respectively. The 1-, 5-, and 10-year freedom from reoperation rates were 92.3%±5.2%, 68.9%±10.2%, and 50.3%±13.6%, respectively. The 1-, 5-, and 10-year freedom from significant aortic dysfunction rates were 91.7%±8.0%, 41.7%±14.2%, and 25.0%±12.5%, respectively.ConclusionHomografts had the advantages of a good hemodynamic profile and low risk of thromboembolic events, and with good outcomes in cases of aortitis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Long-Term Outcomes of Homografts in the Aortic Valve and Root Position: A 20-Year Experience

Kim

Jung

et al. 2016

Korean J Thorac Cardiovasc Surg

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“…At 4 mm from the short edge of the rectangular section, a 4-0 non-absorbable monofilament suture Premilene ® , (Karck and Haverich, 2005;Park et al, 2012) was inserted and tied to form a loop.…”

Section: Biomechanical Performance Ii: Materials Properties (Uniaxial mentioning

confidence: 99%

In vitro biomechanical and hydrodynamic characterisation of decellularised human pulmonary and aortic roots

Desai

Vafaee

Rooney

et al. 2018

Journal of the Mechanical Behavior of Biomedical Materials

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A B S T R A C TBackground and purpose of the study: The use of decellularised biological heart valves in the replacement of damaged heart valves offers a promising solution to reduce the degradation issues associated with existing cryopreserved allografts. The purpose of this study was to assess the effect of low concentration sodium dodecyl sulphate decellularisation on the in vitro biomechanical and hydrodynamic properties of cryopreserved human aortic and pulmonary roots. Method: The biomechanical and hydrodynamic properties of cryopreserved decellularised human aortic and pulmonary roots were fully characterised and compared to cellular human aortic and pulmonary roots in an unpaired study. Following review of these results, a further study was performed to investigate the influence of a specific processing step during the decellularisation protocol ('scraping') in a paired comparison, and to improve the method of the closed valve competency test by incorporating a more physiological boundary condition. Results: The majority of the biomechanical and hydrodynamic characteristics of the decellularised aortic and pulmonary roots were similar compared to their cellular counterparts. However, several differences were noted, particularly in the functional biomechanical parameters of the pulmonary roots. However, in the subsequent paired comparison of pulmonary roots with and without decellularisation, and when a more appropriate physiological test model was used, the functional biomechanical parameters for the decellularised pulmonary roots were similar to the cellular roots. Conclusion: Overall, the results demonstrated that the decellularised roots would be a potential choice for clinical application in heart valve replacement.

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Transplantation of cardiovascular tissue from University Hospital Centre Zagreb tissue banks

Habeković,

Dubravec,

Žigrović

et al. 2023

Cardiologia Croatica

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Midterm Follow-up after Cryopreserved Homograft Replacement in the Aortic Position

Cited by 3 publications

References 11 publications

Long-Term Outcomes of Homografts in the Aortic Valve and Root Position: A 20-Year Experience

Long-Term Outcomes of Homografts in the Aortic Valve and Root Position: A 20-Year Experience

In vitro biomechanical and hydrodynamic characterisation of decellularised human pulmonary and aortic roots

Transplantation of cardiovascular tissue from University Hospital Centre Zagreb tissue banks

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