MIF-1 antagonizes warm-, but not cold-water stress-induced analgesia: Dissociation from immobility

Galina, Zvi Harry; Kastin, Abba J.

doi:10.1016/0196-9781(85)90435-8

Cited by 34 publications

(6 citation statements)

References 23 publications

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“…This once again demonstrates the ability of Tyr-MIF-I to affect behaviour in the same functional manner as the antiopiate naloxone. MIF-I, a related peptide, also has been found to reduce warm-water swim-induced antinociception (Galina & Kastin, 1985). This paper adds further support to the concept that MIF-1/Tyr-MIF-1 peptides have opiate antagonist actions (Galina & Kastin, 1985;Kavaliers & Hirst, 1985;Tesky & Kavaliers, 1985) and are part of an antiopiate system that may function to balance the opiate system (Kastin et al, 1979;Galina & Kastin, 1986).…”

Section: Discussionsupporting

confidence: 62%

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Tyr‐MIF‐1 attenuates antinociceptive responses induced by three models of stress‐analgesia

Galina

Kastin

1987

British J Pharmacology

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Tyr‐MIF‐1 (Tyr‐Pro‐Leu‐Gly‐NH2), a biologically active brain peptide, has previously been shown to antagonize the analgesia induced by morphine. In this report experiments are described in which mice were tested on the hot‐plate in three models of antinociception—shock, novel environment, and warm‐water swim—after the administration of various doses of Tyr‐MIF‐1 without any exogenous opiates. The peptide reduced the antinociception produced by all three methods of inducing endogenous antinociception. These results add further support for the existence of peptides like Tyr‐MIF‐1 that act as opiate antagonists.

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Section: Discussionsupporting

confidence: 62%

“…The control groups were dipped (Dip) in the water for lO s since it has been demonstrated that this is the appropriate control (O'Connor & Chipkin, 1984;Galina & Kastin, 1985). The experimental group was forced to swim for 6 min.…”

Section: Warm-water Swim Analgesiamentioning

confidence: 99%

Tyr‐MIF‐1 attenuates antinociceptive responses induced by three models of stress‐analgesia

Galina

Kastin

1987

British J Pharmacology

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“…1, Nr'uy,,,'hr'rr,., Vot, 66, Nr. 4, 1996 Tyr-MIF-l, an antiopioid peptide (Banks and Kastin, 1984;Galina and Kastin, 1985) and methionine-enkephalin . These studies suggest that this carrier system for small peptides with N-terminal tyrosine residues is separate and distinct from the tyrosine amino acid carrier and has a stereospecificity and clearance that are significantly greater for L-Tyr-MIF-l than D-Tyr-MIF-I (Barrera et al, 1989).…”

Section: Discussionmentioning

confidence: 99%

Polyamine Modification Increases the Permeability of Proteins at the Blood‐Nerve and Blood‐Brain Barriers

Poduslo

Curran

1996

Journal of Neurochemistry

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The permeability of the blood‐nerve barrier (BNB) and the blood‐brain barrier (BBB) to superoxide dismutase (SOD), insulin, albumin, and IgG in normal adult rats was quantified by measuring the permeability coefficient‐surface area product (PS) with the intravenous bolus injection technique before and after covalent protein modification with the naturally occurring polyamines—putrescine (PUT), spermidine (SPD), and spermine (SPM). The PS value of the BNB for PUT‐SOD was 21.1‐fold greater than the native SOD, and the PS values of the BBB for PUT‐SOD ranged from 17.6‐fold greater for the thalamus to 23.6‐fold greater for the caudate‐putamen compared with native SOD. In a similar manner, polyamine‐modified insulin showed a 1.7–2.0‐fold increase in PS of the BNB and BBB compared with the high values of native insulin. Polyamine‐modified albumin showed a remarkable 54–165‐fold increase in PS of the BNB and BBB compared with native albumin, whereas PUT‐IgG resulted in an even higher increase in the PS that ranged from 111‐ to 349‐fold for nerve and different brain regions compared with native IgG. Polyamine modification of proteins, therefore, can dramatically increase the permeability at the BNB and BBB of a variety of proteins with widely differing Mr and function. It is surprising that the PS values of the BNB and BBB decreased with the increasing number of positive charges of the protonated amino groups on the polyamines (PUT > SPD > SPM). Although cationic proteins are known to interact with fixed anionic charges on the lumen of the microvascular endothelium, this observation of decreased permeability with increased positive charge distribution along the aliphatic carbon chain of the polyamines implies mechanisms other than simple electrostatic interaction involving charge density. It is suggested that the polyamine transporter may be responsible for the transport of these polyamine‐modified proteins. Systemic administration of polyamine‐modified peptides and proteins might prove to be an efficient approach to deliver therapeutic agents into the CNS and PNS for the treatment of a variety of neurological diseases.

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“…The number of rotations of the wheel, recorded automatically, is considered an index of attempts to escape. This procedure, adopted by other authors (Galina and Kastin 1985;Kastin et al 1984), gives different results from FST (see Nomura et al 1982b), and therefore data obtained by this procedure were not included in this review. As pointed out previously, due to the great variability in animal response, larger groups of mice (10 20) were used as compared to rats (8-10).…”

Section: Methodological Considerationsmentioning

confidence: 99%

Is the forced swimming test a suitable model for revealing antidepressant activity?

1988

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MIF-1 antagonizes warm-, but not cold-water stress-induced analgesia: Dissociation from immobility

Cited by 34 publications

References 23 publications

Tyr‐MIF‐1 attenuates antinociceptive responses induced by three models of stress‐analgesia

Tyr‐MIF‐1 attenuates antinociceptive responses induced by three models of stress‐analgesia

Polyamine Modification Increases the Permeability of Proteins at the Blood‐Nerve and Blood‐Brain Barriers

Is the forced swimming test a suitable model for revealing antidepressant activity?

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