MIF May Participate in Pathogenesis of Polycystic Ovary Syndrome in Rats through MAPK Signalling Pathway

Zhou, Danni; Li, Saijiao; Ding, Jinli; Yin, Tailang; Yang, Jing; Ye, Hong

doi:10.1007/s11596-018-1953-7

Cited by 14 publications

(12 citation statements)

References 39 publications

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“…The Akt/PKB complex can transport glucose transporters, including Glucose transporter type 4 (GLUT4), to cell membranes, thereby increasing glucose uptake and lowering blood glucose levels [ 44 ]. On the contrary, mitogen-activated protein kinase (MAPK) activation has been linked to IR development by reducing GLUT4 expression and impairing glucose transport [ 45 ]. Chou et al.…”

Section: Discussionmentioning

confidence: 99%

Effects of Rosa damascena on reproductive improvement, metabolic parameters, liver function and insulin-like growth factor-1 gene expression in estradiol valerate induced polycystic ovarian syndrome in Wistar rats

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Effects of Rosa damascena on reproductive improvement, metabolic parameters, liver function and insulin-like growth factor-1 gene expression in estradiol valerate induced polycystic ovarian syndrome in Wistar rats

et al. 2023

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“…Furthermore, it is wellknown that the activation of the NF-κB pathway is mainly regulated by the MAPK pathway. For instance, MAPK pathway activation is observed in PCOS rats, whereas inhibiting the MAPK pathway can reduce in ammation and protect ovarian function [70,71]. MGP treatment reduced P-ERK, P-JNK, and P-P38 expression compared with that of the model group, suggesting that MGP could block the MAPK pathway (Fig.…”

Section: Discussionmentioning

confidence: 89%

Modified Guishen Pill Ameliorates Polycystic Ovary Syndrome in Rats Through Anti-inflammation and Modulating Gut Microbiota

Tian

Zuo

et al. 2021

Preprint

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Background Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder often accompanied by chronic low-grade inflammation. Western medicine often causes negative side effects, such as premature ovarian failure. Therefore, this study evaluates the efficacy of modified Guishen pill (MGP) in ameliorating letrozole-induced PCOS in rats. Methods Six-week-old specific-pathogen free (SPF) female Sprague-Dawley rats were randomly divided into a blank group (Blank), model group (Model), positive group (Diane-35, 0.2 mg/kg BW), high dose MGP group (H.MGP, 23.96 g/kg BW), medium dose MGP group (M.MGP, 11.98 g/kg BW), and low dose MGP group (L.MGP, 5.99 g/kg BW). After 4 weeks of treatment, plasma, ovaries, and fecal samples were collected from the rats for analysis. Results MGP treatment improved ovarian function by improving estrous cycle, ovarian morphology, and endocrine functions in letrozole-induced PCOS rats. MGP alleviated inflammation by reducing macrophage infiltration and inhibiting the activation of NF-κB and MAPK pathways in the ovaries of letrozole-induced PCOS rats. 16S rDNA sequencing of the intestinal microbiome indicated that MGP regulated gut microbiota structure and restored gut microbiota dysbiosis. MGP significantly increased the relative abundance of bifidobacteria at the order, family, and genus levels. Moreover, correlation analysis showed that gut microbiota were correlated with the host phenotype of letrozole-induced PCOS rats. Conclusion MGP treatment could ameliorate letrozole-induced PCOS by improving ovarian function, reducing inflammation, and regulating the gut microbiota.

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“…Table 2 Therefore, environmental control is highly relevant in PCOS research (Walters et al, 2018). (Asghari et al, 2021;Zhou et al, 2018;Cara et al, 2023;Ullah et al, 2022;Esparza et al, 2020;Chu et al, 2020;Linares et al, 2019;Ryu et al, 2023;Wang et al, 2020Ding et al, 2019) Luteinizing Hormone Enzyme-linked immunosorbent assays (ELISA) Liquid chromatography-tandem mass spectrometry Radioimmunoassay (Asghari et al, 2021;Zhou et al, 2018;Cara et al, 2023;Ullah et al, 2022;Esparza et al, 2020;Chu et al, 2020;Ryu et al, 2023;Wang et al, 2020) Follicle Stimulating Hormone Enzyme-linked immunosorbent assays (ELISA) Radioimmunoassay (Asghari et al, 2021;Zhou et al, 2018;Ullah et al, 2022;Chu et al, 2020;Wang et al, 2020;Ding et al, 2019) Progesterone Enzyme-linked immunosorbent assays (ELISA) Liquid chromatography-tandem mass spectrometry Radioimmunoassay (Asghari et al, 2021;Cara et al, 2023;Ullah et al, 2022;Chu et al, 2020;Linares et al, 2019) Estradiol Enzyme-linked immunosorbent assays (ELISA) Liquid chromatography-mass spectrometry (LCMS) assay Radioimmunoassay (Asghari et al, 2021;Zhou et al, 2018;Chu et al, 2020;Esparza et al, 2020;Linares et al, 2019;Ryu et al, 2...…”

Section: Balb/c Micementioning

confidence: 99%

Assessment and Experimental Procedure Polycystic Ovary Syndrome (PCOS) Rat Model: A Review

Kurniawati,

Pramono,

Hidayat

et al. 2023

Jurnal Sain Peternakan Indonesia

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A complicated endocrine condition that affects many women worldwide is called polycystic ovarian syndrome, or PCOS. The use of rat models has greatly aided research on many facets of PCOS. In addition to discussing the parameters, evaluation techniques, and indicators pertinent to PCOS research, this study evaluates the standard circumstances of PCOS rat models. Our knowledge of PCOS has improved due to investigating endocrine, hormonal, inflammatory, oxidative stress, metabolic, genetic, and microbiota-related factors in these models. The results highlight how important it is to use PCOS rat models to understand the complexities of this illness and offer possible treatment avenues.

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MIF May Participate in Pathogenesis of Polycystic Ovary Syndrome in Rats through MAPK Signalling Pathway

Cited by 14 publications

References 39 publications

Effects of Rosa damascena on reproductive improvement, metabolic parameters, liver function and insulin-like growth factor-1 gene expression in estradiol valerate induced polycystic ovarian syndrome in Wistar rats

Effects of Rosa damascena on reproductive improvement, metabolic parameters, liver function and insulin-like growth factor-1 gene expression in estradiol valerate induced polycystic ovarian syndrome in Wistar rats

Modified Guishen Pill Ameliorates Polycystic Ovary Syndrome in Rats Through Anti-inflammation and Modulating Gut Microbiota

Assessment and Experimental Procedure Polycystic Ovary Syndrome (PCOS) Rat Model: A Review

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