Mifepristone as cervical ripening agent for Labour induction in women with Previous one Caesarean Section

Bhattacharya, Dr Rajiv; Chaudhari, Dr Priyanka; Choudhary, Dr Anjali; Sharma, Dr Arti; Jain, Dr Shweta

doi:10.17511/ijmrr.2016.i04.25

Cited by 2 publications

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“…This was also observed in study by Acharya et al, where 14% subjects entered in active phase of labour with mifepristone only and Sharma et al where 56% women had labour onset within 48 hours of mifepristone administration. 15,12 Thus, it is concluded that in addition to Foleys catheter prior ripening with mifepristone had better success rate in IOL.…”

Section: Discussionmentioning

confidence: 97%

Comparison of the efficacy, safety, acceptability and fetomaternal outcomes of combination of mifepristone and foley’s catheter with foley’s catheter alone in induction of labour in term pregnancies with previous lower segment caesarean section

Thind¹,

Sood²,

Sood³

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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Background: Objective of the study was to compare the efficacy, safety, acceptability, fetomaternal outcomes of combination of mifepristone and Foley’s catheter with Foley’s catheter alone in induction of labor in term pregnancies with previous Lower segment caesarean section (LSCS).Methods: This was a prospective study of 36 women induced with mifepristone and foley’s catheter and 36 women induced with foley’s catheter alone at 37 weeks to 41+6 weeks with previous LSCS.Results: Mean bishop score on admission in combined group (2.44) was comparable with that of foley’s alone group (2.91, p=0.888). Mean Bishop score (BS) after foley’s expulsion in group A and group B was 7.46 and 6.33 respectively, which was statistically significant (p<0.001). In group A 69.5% of women delivered vaginally compared to 52.2% in group B which was comparable (p=0.230). Mean induction to delivery interval was significantly short in combination group (15.5±1.3 hours versus 20.8±1.07 hours, p=0.003). 50% women in group A required oxytocin for induction/ augmentation of labour as compared to 77.8% in group B (p=0.02). Failed induction was statistically higher in group B (p<0.05). No difference was found with regards scar dehiscence, scar rupture, Postpartum hemorrhage (PPH), wound infection, puerperal pyrexia, Meconium stained liquor (MSL), fetal distress, mean birth weight, 1 and 5 minutes Appearance, pulse, grimace, activity, and respiration (APGAR) score, neonatal outcome, hospital stay.Conclusions: Priming with mifepristone before insertion of foley’s catheter results in significant change in BS signifying that combination promotes early cervical ripening as compared to foley’s catheter alone. Mifepristone plays significant role in cervical ripening, reduces induction to delivery interval, oxytocin requirement and failed induction.

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Section: Discussionmentioning

confidence: 97%

Comparison of the efficacy, safety, acceptability and fetomaternal outcomes of combination of mifepristone and foley’s catheter with foley’s catheter alone in induction of labour in term pregnancies with previous lower segment caesarean section

Thind¹,

Sood²,

Sood³

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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show abstract

“…[11] An ideal inducing agent must be effective, non-invasive, economical, and safe to mother and fetus. [12] It must achieve labor in shortest possible time, with lower incidence of failure Objective: To compare the efficacy of sublingual misoprostol tablet and intracervical dinoprostone gel for induction of labor and also to assess the maternal and fetal outcome after induction. Methodology: A prospective observational study was conducted over a period of 6 months.…”

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confidence: 99%

A Comparative Study between Sublingual Misoprostol (PGE₁) versus Intracervical Dinoprostone Gel (PGE₂) in the Induction of Labor:- A Prospective Observational Study

Deepika

Nagabushan

Manohar

2019

Journal of Pharmacology and Pharmacotherapeutics

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Mifepristone as cervical ripening agent for Labour induction in women with Previous one Caesarean Section

Cited by 2 publications

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Comparison of the efficacy, safety, acceptability and fetomaternal outcomes of combination of mifepristone and foley’s catheter with foley’s catheter alone in induction of labour in term pregnancies with previous lower segment caesarean section

Comparison of the efficacy, safety, acceptability and fetomaternal outcomes of combination of mifepristone and foley’s catheter with foley’s catheter alone in induction of labour in term pregnancies with previous lower segment caesarean section

A Comparative Study between Sublingual Misoprostol (PGE₁) versus Intracervical Dinoprostone Gel (PGE₂) in the Induction of Labor:- A Prospective Observational Study

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Mifepristone as cervical ripening agent for Labour induction in women with Previous one Caesarean Section

Cited by 2 publications

References 0 publications

Comparison of the efficacy, safety, acceptability and fetomaternal outcomes of combination of mifepristone and foley’s catheter with foley’s catheter alone in induction of labour in term pregnancies with previous lower segment caesarean section

Comparison of the efficacy, safety, acceptability and fetomaternal outcomes of combination of mifepristone and foley’s catheter with foley’s catheter alone in induction of labour in term pregnancies with previous lower segment caesarean section

A Comparative Study between Sublingual Misoprostol (PGE1) versus Intracervical Dinoprostone Gel (PGE2) in the Induction of Labor:- A Prospective Observational Study

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A Comparative Study between Sublingual Misoprostol (PGE₁) versus Intracervical Dinoprostone Gel (PGE₂) in the Induction of Labor:- A Prospective Observational Study