MIG-6 negatively regulates STAT3 phosphorylation in uterine epithelial cells

Yoo, Jeong-Eun; Yang, Woo Sub; Lee, Jae Hee; Kim, Byung Gak; Broaddus, Russell R.; Lim, Jeong Mook; Kim, Tae Hoon; Jeong, Jaewook

doi:10.1038/onc.2017.335

Cited by 17 publications

(13 citation statements)

References 47 publications

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“…Gene 33 has been shown to interact with the adapter protein SHC1, thereby inhibiting its tyrosine phosphorylation at Tyr239/240 [ 43 ]. It may also interact with STAT3, thereby inhibiting its phosphorylation [ 44 ]. However, the domains of Gene 33 that mediate these interactions remain to be determined.…”

Section: Molecular Biology Of Gene 33mentioning

confidence: 99%

Gene 33/Mig6/ERRFI1, an Adapter Protein with Complex Functions in Cell Biology and Human Diseases

2021

Cells

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Gene 33 (also named Mig6, RALT, and ERRFI1) is an adapter/scaffold protein with a calculated molecular weight of about 50 kD. It contains multiple domains known to mediate protein–protein interaction, suggesting that it has the potential to interact with many cellular partners and have multiple cellular functions. The research over the last two decades has confirmed that it indeed regulates multiple cell signaling pathways and is involved in many pathophysiological processes. Gene 33 has long been viewed as an exclusively cytosolic protein. However, recent evidence suggests that it also has nuclear and chromatin-associated functions. These new findings highlight a significantly broader functional spectrum of this protein. In this review, we will discuss the function and regulation of Gene 33, as well as its association with human pathophysiological conditions in light of the recent research progress on this protein.

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Section: Molecular Biology Of Gene 33mentioning

confidence: 99%

Gene 33/Mig6/ERRFI1, an Adapter Protein with Complex Functions in Cell Biology and Human Diseases

2021

Cells

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“…Mitogen-inducible gene 6 (Mig-6) (also known as gene 33 [5], ErbB receptor feedback inhibitor 1 (Errfi1) [6], and receptor associated late transducer (RALT)) [7], is located on human chromosome 1p36.23 [8]. It encodes a cytosolic multiadaptor protein [9], that has an important tumor suppressor function [10] and it plays a role in modulating the response to steroid hormones in the uterus.…”

Section: Introductionmentioning

confidence: 99%

Expression Pattern of Mitogen-inducible Gene 6 in Relation to the Extracellular Signal-regulated Kinase Pathway and Redox Status in Patients with Endometriosis

Ayad

Gaballah

Salem

et al. 2020

AJBGMB

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Background: Endometriosis is a gynecological disorder characterized by the presence of ectopic endometrium outside the uterus. It is a multi-factorial disease, where different processes facilitate the implantation and survival of ectopic endometrial tissue. The Aim: This study aims to evaluate the levels of the expression patterns of mitogen-inducible gene 6 (Mig-6) in eutopic and ectopic endometrial tissues of endometriosis patients and their relevance to the levels of phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2) and redox status. Methods: Relative gene expression levels of Mig-6 and the levels of pERK1/2 were assessed in endometrial tissues of control group and in both eutopic and ectopic endometrial tissues of endometriosis patients .Serum levels of total protein thiols and total protein carbonyls were also assessed in endometriosis and control groups. Results: Relative gene expression levels of Mig- 6 showed significant lower values in endometriosis group as compared to control group, and they were associated with significant increase in pERK 1/2 levels and altered redox status. Conclusion: These data, signified a significant role of downregulated Mig-6 expression, and activated ERK 1/2 signaling in the pathogenesis of endometriosis. Moreover, it suggested that oxidative stress indicated by high protein carbonyls level contributes to the pathogenesis of endometriosis and that protein thiols have a defensive role against oxidative stress.

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“…Specifically, reduced expression of PGR has been associated with endometriosis, a prevalent disease in women’s health (Grandi et al, 2017). Overall, aberrations of steroid hormone signaling can be found in many uterine disorders including infertility, endometriosis, endometrial cancer, and uterine leiomyoma (Han & O’Malley, 2014; Islam et al, 2017; Patel et al, 2017; Yoo et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Proline-Rich Acidic Protein 1 (PRAP1) is a Target of ARID1A and PGR in the Murine Uterus

Kim¹,

Jeong²

2019

Dev. Reprod.

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ARID1A and PGR plays an important role in embryo implantation and decidualization during early pregnancy. Uterine specific Arid1a knockout (Pgrcre/+Arid1af/f) mice exhibit in non-receptive endometrium at day 3.5 of gestation (GD 3.5). In previous studies, using transcriptomic analysis in the uterus of Pgrcre/+Arid1af/f mice, we identified proline-rich acidic protein 1 (PRAP1) as one of the down-regulated genes by ARID1A in the uterus. In the present study, we performed RT-qPCR and immunohistochemistry analysis to investigate the regulation of PRAP1 by ARID1A and determine expression patterns of PRAP1 in the uterus during early pregnancy. During early pregnancy, PRAP1 expression was strong at day 0.5 of gestation (GD 0.5) and then decreased at GD 3.5 in the epithelium and stroma. After implantation, PRAP1 expression was remarkably reduced in the uterus. However, the expression of PRAP1 at GD 3.5 was remarkably increased in the Pgrcre/+Arid1a f/f mice. To determine the ovarian steroid hormone regulation of PRAP1, we examined the expression of PRAP1 in ovariectomized control, Pgrcre/+Arid1af/f, and progesterone receptor knock-out (PRKO) mice treated with progesterone. While PRAP1 proteins were strongly expressed in the luminal and glandular epithelium of control mice treated with vehicle, progesterone treatment suppressed the expression of PRAP1. However, PRAP1 was not suppressed in both the Pgrcre/+Arid1af/f and PRKO mice compared to controls. Our results identified PRAP1 as a novel target of ARID1A and PGR in the murine uterus.

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MIG-6 negatively regulates STAT3 phosphorylation in uterine epithelial cells

Cited by 17 publications

References 47 publications

Gene 33/Mig6/ERRFI1, an Adapter Protein with Complex Functions in Cell Biology and Human Diseases

Gene 33/Mig6/ERRFI1, an Adapter Protein with Complex Functions in Cell Biology and Human Diseases

Expression Pattern of Mitogen-inducible Gene 6 in Relation to the Extracellular Signal-regulated Kinase Pathway and Redox Status in Patients with Endometriosis

Proline-Rich Acidic Protein 1 (PRAP1) is a Target of ARID1A and PGR in the Murine Uterus

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