MIGHT <i>STREPTOCOCCUS PNEUMONIAE</i> URINARY ANTIGEN TEST BE POSITIVE BECAUSE OF PNEUMOCOCCAL VACCINE?

Priner, M.; Cornillon, Catherine; Forestier, Damien; Valéro, Simon; Pocard, Marc

doi:10.1111/j.1532-5415.2007.01451.x

Cited by 15 publications

(10 citation statements)

References 7 publications

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“…There are, however, some potential circumstances that need additional careful evaluation. For example, several studies have demonstrated that S. pneumoniae antigens can be detected in the urine up to 3 months postinfection (2,27,43) and up to 7 days postvaccination with S. pneumoniae polysaccharide vaccine (38). Thus, assay results should take into account clinical and chest X-ray findings at the time that the urine specimen is obtained.…”

Section: Discussionmentioning

confidence: 99%

Validation of an Immunodiagnostic Assay for Detection of 13 Streptococcus pneumoniae Serotype-Specific Polysaccharides in Human Urine

Pride

Huijts

et al. 2012

Clin Vaccine Immunol

104

137

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gTo improve the clinical diagnosis of pneumococcal infection in bacteremic and nonbacteremic community-acquired pneumonia (CAP), a Luminex technology-based multiplex urinary antigen detection (UAD) diagnostic assay was developed and validated. The UAD assay can simultaneously detect 13 different serotypes of Streptococcus pneumoniae by capturing serotype-specific S. pneumoniae polysaccharides (PnPSs) secreted in human urine. Assay specificity is achieved by capturing the polysaccharides with serotype-specific monoclonal antibodies (MAbs) on spectrally unique microspheres. Positivity for each serotype was based on positivity cutoff values calculated from a standard curve run on each assay plate together with positive-and negative-control urine samples. The assay is highly specific, since significant signals are detected only when each PnPS was paired with its homologous MAb-coated microspheres. Validation experiments demonstrated excellent accuracy and precision. The UAD assay and corresponding positivity cutoff values were clinically validated by assessing 776 urine specimens obtained from patients with X-ray-confirmed CAP. The UAD assay demonstrated 97% sensitivity and 100% specificity using samples obtained from patients with bacteremic, blood culture-positive CAP. Importantly, the UAD assay identified Streptococcus pneumoniae (13 serotypes) in a proportion of individuals with nonbacteremic CAP, a patient population for which the pneumococcal etiology of CAP was previously difficult to assess. Therefore, the UAD assay provides a specific, noninvasive, sensitive, and reproducible tool to support vaccine efficacy as well as epidemiological evaluation of pneumococcal disease, including CAP, in adults.

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Section: Discussionmentioning

confidence: 99%

Validation of an Immunodiagnostic Assay for Detection of 13 Streptococcus pneumoniae Serotype-Specific Polysaccharides in Human Urine

Pride

Huijts

et al. 2012

Clin Vaccine Immunol

104

137

View full text Add to dashboard Cite

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“…Concernant l'intérêt de l'antigénurie, il faut avoir en mémoire le risque d'influence du portage nasopharyngé et le fait que la positivité peut persister plusieurs semaines après une infection à pneumocoque [13,14]. En revanche, la vaccination antipneumocoque ne positive que très transitoirement l'antigénurie [15].…”

Section: Généralitésunclassified

Pneumopathie à pneumocoque et prévention vaccinale

Delelis-Fanien

Seite

Pocard

2009

cah. année gerontol.

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Les sujets âgés sont particulièrement exposés au risque d'infections pulmonaires à Streptococcus pneumoniae. Nous rapportons les données épidémiologiques concernant la pneumopathie à pneumocoque et les données de la littérature concernant la vaccination. Les études prospectives, probablement par manque de puissance, ne montrent pas une protection vaccinale significative pour prévenir la survenue d'une pneumopathie. Néanmoins, l'intérêt de la vaccination pour prévenir les formes sévères et la bonne tolérance de la vaccination plaident en faveur d'une meilleure information pour une application plus soutenue de la recommandation vaccinale antipneumococcique chez les patients gériatriques. Mots clés Pneumocoque · Pneumopathie · Gériatrie · VaccinationAbstract Streptococcus pneumoniae is still a major cause of pneumonia, particularly in the elderly. We report, herein, the epidemiological data concerning this disease and the literature data relative to the pneumococcal vaccine. Prospective studies do not demonstrate any significant effect of vaccination against pneumonia. Nevertheless, the benefits of this vaccine with regard to more severe forms should be better communicated to the public in order to increase its coverage in geriatric patients.

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“…However, the BinaxNOW ® has significant limitations, including cross-reaction with other closely related streptococci [10], false-positive results due to the presence of indigenous S. pneumoniae, especially in children [4,11], and the detection of antigens even one to three months after treatment for pneumococcal infections [5,6,12]. In addition, the kit may yield positive findings due to the effects of the pneumococcal vaccine [13].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a rapid immunochromatographic ODK0501 assay for detecting Streptococcus pneumoniae antigens in the sputum of pneumonia patients with positive S. pneumoniae urinary antigens

Mukae

Yatera

Noguchi

et al. 2015

Journal of Infection and Chemotherapy

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MIGHT STREPTOCOCCUS PNEUMONIAE URINARY ANTIGEN TEST BE POSITIVE BECAUSE OF PNEUMOCOCCAL VACCINE?

Cited by 15 publications

References 7 publications

Validation of an Immunodiagnostic Assay for Detection of 13 Streptococcus pneumoniae Serotype-Specific Polysaccharides in Human Urine

Validation of an Immunodiagnostic Assay for Detection of 13 Streptococcus pneumoniae Serotype-Specific Polysaccharides in Human Urine

Pneumopathie à pneumocoque et prévention vaccinale

Evaluation of a rapid immunochromatographic ODK0501 assay for detecting Streptococcus pneumoniae antigens in the sputum of pneumonia patients with positive S. pneumoniae urinary antigens

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