Migraine and cardiovascular disease: systematic review and meta-analysis

Schürks, Markus; Rist, Pamela M.; Bigal, Marcelo E.; Buring, Julie E.; Lipton, Richard B.; Kurth, Tobias

doi:10.1136/bmj.b3914

Cited by 706 publications

(712 citation statements)

References 29 publications

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“…Pre-eclampsia is itself associated with pre-term birth, perinatal death 3 and with infant stroke in the perinatal period, 24 and also with risk of maternal pregnancy-associated stroke 7 and with long-term stroke risk in the mother. 4 In preeclampsia, 25,26 as in migraine, 27,28 there are features of endothelial dysfunction, platelet activation and inflammation.…”

Section: Migraine and Preterm Birthmentioning

confidence: 99%

“…Other indications that factors relevant to reproductive function interact with propensity to migraine are the concentration in some women of migraine headaches at the time of menstrual periods and the commonly observed decline of migraine attacks during pregnancy or after menopause. 3 Ischemic stroke is more common in women with than without migraine, 4,5 and risk is increased in those taking oral contraceptives. 6 There is a striking increase in frequency of pregnancy-associated stroke in women with a history of migraine, although the absolute level of that risk is low.…”

Section: Introductionmentioning

confidence: 99%

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Migraine and preterm birth

Blair

Nelson

2010

J Perinatol

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Objective: To investigate whether maternal migraine was associated with preterm birth.Study Design: Case-control sample within a population-based study of risk factors for cerebral palsy (CP). Infants without CP were matched for gestational age with those with CP. Maternal migraine was self-identified at first prenatal visit, most in the first trimester.Result: Infants without CP born to women with migraine had a higher rate of preterm birth (odds ratio (OR) ¼ 3.5, 95% confidence interval (CI) 1.5, 8.5), as did infants who died in the perinatal period (OR ¼ 7.3, 95% CI 0.98, 54), the difference marginal for nominal statistical significance. In all outcome groups, infants of women with migraine had a higher observed rate of suboptimal intrauterine growth. In term infants, the rate of maternal migraine was higher in those with CP than in controls (OR ¼ 2.18, 95% CI 0.92, 5.25). Pre-eclampsia was reported more frequently in women with migraine who gave birth to a child with CP or a perinatal death, particularly in those born preterm; OR ¼ 5.1 (1.3, 20) and OR ¼ 2.9 (1.1, 7.6), respectively, but not in women giving birth to a control whether term or preterm.Conclusion: Maternal migraine, as self-reported early in pregnancy, was associated with preterm birth in survivors without CP and in infants who died in the perinatal period. The combination of maternal migraine and pre-eclampsia was associated with CP and perinatal death. The association of maternal migraine with outcomes of pregnancy warrants further study.

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Section: Migraine and Preterm Birthmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Migraine and preterm birth

Blair

Nelson

2010

J Perinatol

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“…The clinical features of GIDs in migraine patients are most commonly characterized by the effects of acidic gastric juice on mandibular teeth (14). Several studies have demonstrated possible relationship between cardiovascular diseases (CVDs) and migraine (4,15,16). The functional significance of CVDs in migraine patients is that poor oral hygiene could be a predisposing factor for infective endocarditis caused by streptococcal bacteria (17).…”

Section: Introductionmentioning

confidence: 99%

“…This disorder is most commonly experienced between the ages of 15 and 55 years, and 70% to 80% of sufferers have a family history of migraine (3). A widely accepted neurovascular theory of migraine etiology consists of dural and meningeal vascular dilatation, perivascular inflammation, and nociceptor activation (4). The reflection of migraine pain to the temporomandibular, facial, and maxillary areas has been ascribed to vascular dilatation and inflammation of the trigeminal nerve, which emanates from the brainstem and innervates the orofacial area (5).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the relationship between migraine disorder andoral comorbidities: multicenter randomized clinical trial

Peşkersoy¹,

Peker²,

Kaya³

et al. 2016

Turk J Med Sci

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Background/aim: Although migraine is a common disorder, there is a lack of research investigating the possible relationship between migraine and oral health. The aim of the present study was to explore the relationship between temporomandibular disorders, bruxism, dental caries, periodontal status, and migraine disorder in a multicenter, parallel, case-controlled clinical study. Materials and methods:A total of 2001 participants were divided into two groups: migraineurs (nm = 998) and nonmigraineurs (nh = 1003). International Headache Society's Second Edition of International Classification of Headache Disorders and modified Migraine Disability Assessment surveys were administered to evaluate the level of migraine; a pretreatment questionnaire and the World Health Organization oral health assessment form were used to determine the oral comorbidities and their possible effects on DMFT index, gingival plaque index, existence of temporomandibular disorders, bruxism, and consistency of daily oral hygiene habits. Results:The mean age was 39.6 ± 10.5 years. Female patients seemed to experience migraine attacks more than male patients (64%). The frequency of gastroesophageal reflux was higher in migraineurs in comparison with nonmigraineurs (47%) and tooth wear and abrasion also seemed more frequent (76%). DMFT and plaque index scores showed significant differences for both groups. Conclusion:There is a strong relationship between migraine and oral health status. The existence of reflux in addition to migraine leads to higher dental problems.

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“…Since the available evidence on the topic increased considerably over the past years, a recently published me-ta-analyses sought to assess the current evidence on the association between migraine and various CVD events, including stroke subtypes, angina, myocardial infarction (MI), and CVD death 52 (Table 2). Studies were heterogeneous with regard to the characteristics of investigated subjects and definition of cardiovascular events.…”

Section: Summarizing the Evidencementioning

confidence: 99%

Migraine and cardiovascular disease

Bigal

2011

Arq. Neuro-Psiquiatr.

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Migraine, especially migraine with aura is an established risk factor for ischemic lesions of the brain. Recent evidence has also linked migraine with and without aura to a broader range of ischemic vascular disorders including angina, myocardial infarction, coronary revascularization, claudication and cardiovascular mortality. The topic is therefore of considerable interest. Accordingly, herein we review the association between migraine and cardiovascular disease. We start by briefly presenting diagnostic criteria for migraine and revising its pathophysiology. We follow by summarizing the evidence on the topic. We then briefly present the results of a recent meta-analysis. We close by highlighting results of a large epidemiological study conducted after the publication of the meta-analysis. Key words: migraine, cardiovascular disease, stroke. Migrânea e doenças cardiovasculares RESUMOA migrânea, especialmente a migrânea com aura, é fator de risco para lesões cerebrais. Evidência recente sugere que migrânea com e sem aura é associada com outras doenças cardiovasculares isquêmicas, incluindo a angina, o infarto do miocárdio, revascularização coronária, claudicação e morte súbita. Iniciamos discutindo o diagnóstico da migrânea e seus mecanismos fisiopatológicos. Após sumarizar a evidência, discutimos resultados de meta-análise recente. Por fim, ressaltamos resultados de um grande estudo populacional sobre o assunto. Palavras-chave: migrânea, doença cardiovascular, acidente vascular cerebral.

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Migraine and cardiovascular disease: systematic review and meta-analysis

Abstract: Objective To evaluate the association between migraine and cardiovascular disease, including stroke, myocardial infarction, and death due to cardiovascular disease. Design Systematic review and meta-analysis.

Cited by 706 publications

References 29 publications

Migraine and preterm birth

Migraine and preterm birth

Evaluation of the relationship between migraine disorder andoral comorbidities: multicenter randomized clinical trial

Migraine and cardiovascular disease

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