Migraine and Gastroparesis

Arca, Karissa N.; Cai, Jacqueline; Wang, Fangfang; Kassim, Gassan; Hasler, William L.; Batheja, Mashal

doi:10.1007/s11910-022-01241-3

Cited by 5 publications

(2 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inflammation associated with GERD or esophageal dysmotility may stimulate the vagus or sympathetic nervous system, resulting in autonomic dysregulation, particularly an imbalance between the functions of the parasympathetic and sympathetic nervous systems [ 62 ]. This imbalance may result in vascular dilation, altered blood flow, and abnormal neuronal activity, further enhancing the sensitization of pain centers and increasing the risk of migraine [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Migraine and gastroesophageal reflux disease: Disentangling the complex connection with depression as a mediator

Shen,

Bian,

Huang

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Objective Gastroesophageal reflux disease (GERD) and migraine are public health concerns worldwide. No observational study has conclusively elucidated the causal relationship between these two conditions. We employed Mendelian randomization (MR) methods to explore the potential causal links between GERD and migraine. Methods Genome-wide association studies were subjected to MR to infer the causality between GERD and migraine. Bidirectional two-sample MR was performed to establish causal relationships. Multivariable MR analysis was conducted to adjust potential confounding factors, and mediation MR analysis was utilized to assess the role of depression between GERD and migraine as a mediator. We primarily utilized the inverse variance weighted method (IVW) and sensitivity analysis methods, including MR-Egger, weighted median, and leave-one-out methods. We assessed heterogeneity and pleiotropy to ensure the reliability of the results. Results Bidirectional two-sample MR revealed a positive causal effect of GERD on migraine (IVW: OR = 1.49, 95% CI: 1.34–1.66, p = 3.70E-13). Migraine did not increase the risk of GERD (IVW: OR = 1.07, 95% CI: 0.98–1.17, p = 0.1139). Multivariable MR indicated that the positive causal effect of GERD on migraine remained after adjustment for factors, such as smoking, alcohol consumption, obesity, type 2 diabetes, and depression. Mediation MR revealed that depression mediated 28.72% of GERD’s effect on migraine. MR analysis was supported by all sensitivity analyses and was replicated and validated in another independent dataset on migraine. Conclusion Our findings elucidate the positive causal effect of GERD on migraine and underscores the mediating role of depression in increasing the risk of migraine due to GERD. Effective control of GERD, particularly interventions targeting depression, may aid in preventing the occurrence of migraine. Future research should delve deeper into the specific pathophysiological mechanisms through which GERD affects migraine risk, facilitating the development of more effective drug targets or disease management strategies.

show abstract

Section: Discussionmentioning

confidence: 99%

Migraine and gastroesophageal reflux disease: Disentangling the complex connection with depression as a mediator

Shen,

Bian,

Huang

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Migraine is a complicated genetic disorder characterized by episodes of moderate-to-severe headaches that are usually unilateral and are frequently accompanied by nausea and increased sensitivity to sound and light. A migraine attack can cause intense pain that affects a person from carrying on their daily activities and can last for hours or even days [2][3][4].…”

Section: A Migrainementioning

confidence: 99%

Enhancing Migraine Management System through Weather Forecasting for a Better Daily Life

Ong,

Ho,

Tan

2023

JIWE

View full text Add to dashboard Cite

A migraine is a severe, throbbing, or pulsing headache that typically affects one side of the head. A migraine attack can be so painful that it interferes with daily activities and can last for hours or even days. Migraine is a common health issue that affects approximately 1 in every 5 women and 1 in every 15 men. Additionally, millions of people worldwide suffer from migraine attacks due to the inability to anticipate or adapt to their environment. In today's globalized world, mobile phones have become a necessity for the general public, enabling communication, internet shopping, food purchases, and even health applications. Therefore, the purpose of this research is to develop a mobile application that serves as an online migraine management system that is responsive to meteorological conditions. The app was created using development tools such as Android Studio, Visual Code Studio, Flutter framework, and Firebase Firestore, which act as databases. This report also includes essential information on migraines and a comparison of similar or existing applications. In addition, the research is designed to provide a reliable and user-friendly interface for collecting migraine data for robust evidence, processing relevant demographic features such as medical history, and generating reports. While researching topics relevant to the application, we found a scarcity of data on weather-based migraines. As a result, the system will predict the impact and risk of migraine based on Headache Impact Test (HIT-6) data provided by migraine patients as well as weather forecasts. With the features of this research, migraine patients can hopefully better prepare themselves for their daily routine and manage their symptoms more effectively.

show abstract

Transcutaneous stimulation as a niche theme in gastroparesis therapy

SALEH,

Valentina,

Saputra

2024

F1000Res

View full text Add to dashboard Cite

Introduction Gastroparesis is a condition characterized by the accumulation of bile salts. It is prevalent globally, with a global prevalence of 0.9% and 1.3% in individuals with diabetes. New techniques for diagnosing gastroparesis, such as bile salt titration and nitric oxide sulfate, can improve patient care. However, simptomatic control is needed to increase gastric salts, reduce inflammation, and control potential diseases. Gastroparesis can cause complications like weight loss, malnutrition, and gastrointestinal changes that cannot be predicted. Neurological techniques like gyroscope stimulation and endoscopy (G-POEM) can help diagnose refractive gastroparesis. Interdisciplinary collaboration is crucial in addressing gastroparesis issues, and bibliometric research is essential for finding effective new treatments. Methods In this work, a literature review methodology is employed to gather data from the Scopus database using the keywords neuroaid. Data were analyzed using Biblioshiny and VOSviewer software to produce visualizations and bibliometric maps. We conducted quantitative and qualitative analysis. Results The research trend found are documents by year, most relevant sources, factorial map of the most cited documents, factorial map of The documents with the highest contributes, documents by author, documents by country or territory, documents by subject area, documents by affiliation, network visualization, overlay visualization of scopus database using vosviewer, density visualization, thematic map, thematic evolution, cluster analysis, topic dendogram, and country collaboration map. Conclusions The study on gastroparesis identifies key themes such as diet modification, glucose control, and medication therapy. It also discusses the role of Cajal in smooth muscle concentration, common causes of gastroparesis, and transcutaneous stimulation. The study also explores motorcycle themes, such as the vagus nerve, and emerging themes like devices and electronics. Basic themes include gastrointestinal disorders, neuromodulation, patients, diabetes, and gastric electrical stimulation. Management involves multidisciplinary approaches, lifestyle changes, medication therapy, and bedtime interventions.

show abstract

Migraine and Gastroparesis

Cited by 5 publications

References 59 publications

Migraine and gastroesophageal reflux disease: Disentangling the complex connection with depression as a mediator

Migraine and gastroesophageal reflux disease: Disentangling the complex connection with depression as a mediator

Enhancing Migraine Management System through Weather Forecasting for a Better Daily Life

Transcutaneous stimulation as a niche theme in gastroparesis therapy

Contact Info

Product

Resources

About