Migraine and metabolism

Casucci, Gerardo; Villani, Veronica; Concolino, Daniela; d’Onofrio, Florindo

doi:10.1007/s10072-012-1047-4

Cited by 27 publications

(22 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…83 Shared metabolic pathways are well described between migraine and obesity. 122 Initially, their link was seen as symptom interlay (food cravings, thirst, insomnia, mood instabilities). 123 Later, interconnection of obesity and migraine headaches was demonstrated at the hypothalamic level with functional imaging during migraine episodes.…”

Section: Metabolic and Inflammation Mechanismsmentioning

confidence: 99%

Obesity and Chronic Pain

Narouze

Souzdalnitski

2015

Regional Anesthesia and Pain Medicine

114

View full text Add to dashboard Cite

The combination of obesity and pain may worsen a patient's functional status and quality of life more than each condition in isolation. We systematically searched PubMed/MEDLINE and the Cochrane databases for all reports published on obesity and pain. The prevalence of combined obesity and pain was substantial. Good evidence shows that weight reduction can alleviate pain and diminish pain-related functional impairment. However, inadequate pain control can be a barrier to effective lifestyle modification and rehabilitation. This article examines specific pain management approaches for obese patients and reviews novel interventional techniques for treatment of obesity. The infrastructure for simultaneous treatment of obesity and pain already exists in pain medicine (eg, patient education, behavioral medicine approaches, physical rehabilitation, medications, and interventional treatment). Screening for obesity, pain-related disability, and behavioral disorders as well as monitoring of functional performance should become routine in pain medicine practices. Such an approach requires additional physician and staff training. Further research should focus on better understanding the interplay between these 2 very common conditions and the development of effective treatment strategies.

show abstract

Section: Metabolic and Inflammation Mechanismsmentioning

confidence: 99%

Obesity and Chronic Pain

Narouze

Souzdalnitski

2015

Regional Anesthesia and Pain Medicine

114

View full text Add to dashboard Cite

show abstract

“…Migraineurs are much more likely to have metabolic disorders than non-migraineurs [23][24][25][26][27][28][29] which we speculated is connected to carbohydrate disturbance of electrolytes [30]. Additionally, migraineurs have only nominal changes in voltage between states of action potential versus resting potential, indicating that a migraine brain is "always on," [31,32] supporting the theory that migraineurs have hyper sensitive sensory organs [33,34].…”

Section: Introductionmentioning

confidence: 55%

Migraine Cause And Treatment

Stanton¹

2015

Ment Health Fam Med

View full text Add to dashboard Cite

Background:Research shows that migraine brains have hyperactive sensory organs and multiple sensory receptor connections. Hyper activity of these organs needs extra supply of nutrition to support increased electrical activity. Today's medicines reduce or prevent the functioning of these neurons by blocking essential voltage dependent calcium or sodium channel instead of providing nutrients. We asked: if we provide support for extra electrical activity of migraineurs, would it prevent migraines without the use of medicines? Methods:We reviewed published literature and conducted research over 6 months studying 650 volunteer migraineurs in a migraine-research Facebook group. Participants were screened for migraine types, answered a questionnaire on medical conditions, medicines used, and lifestyle. They were provided instructions on the use of the migraine protocol and were evaluated weekly. Findings:Migraine frequency appears to be exacerbated by carbohydrate-rich and salt-and water-poor diets and may be worsened by medicines that block voltage gated calcium or sodium channels. Stopping these medicines, reducing carbohydrates and increasing saline in electrolytes appears to prevent and/or stop migraines.Conclusions: H 2 O and Na+ efflux from cells caused by glucose, electrolyte mineral (Na+, Cl-, K+) ratio may be disrupted in carbohydrate heavy diets causing migraines. Changes to diet that include increased salt intake along with reduced carbohydrate intake appears to prevent glucose induced electrolyte changes which then decreases migraine frequency. In the present study, all participants who made these dietary changes were able to eliminate migraine medications and remained migraine free.

show abstract

“…Although it was a criterion for exclusion from analysis, maternal pregestational diabetes was much more common among infants with single ventricle compared with control infants and compared with infants with other types of birth defects. The relationship between diabetes and migraines is not well understood; however, there is evidence of an association between insulin‐resistance and migraine headaches . It is possible that untreated/undiagnosed insulin resistance is a confounding factor in the analysis of migraine medications and single ventricle.…”

Section: Discussionmentioning

confidence: 99%

“…The relationship between diabetes and migraines is not well understood; however, there is evidence of an association between insulinresistance and migraine headaches. 19 It is possible that untreated/undiagnosed insulin resistance is a confounding factor in the analysis of migraine medications and single ventricle. Given the small number of infants with single ventricle exposed to either butalbital or triptans, our findings may also be explained by chance.…”

Section: Discussionmentioning

confidence: 99%

Maternal Butalbital Use and Selected Defects in the National Birth Defects Prevention Study

et al. 2013

View full text Add to dashboard Cite

We observed relationships between maternal periconceptional butalbital use and certain congenital heart defects. These associations have not been reported before, and some may be spurious. Butalbital use was rare and despite the large size of the National Birth Defects Prevention Study, the number of exposed case and control infants was small. However, if confirmed in additional studies, our findings will be useful in weighing the risks and benefits of butalbital for the treatment of migraine and tension-type headaches.

show abstract

Migraine and metabolism

Cited by 27 publications

References 59 publications

Obesity and Chronic Pain

Obesity and Chronic Pain

Migraine Cause And Treatment

Maternal Butalbital Use and Selected Defects in the National Birth Defects Prevention Study

Contact Info

Product

Resources

About