Migraine and multiple sclerosis.

Watkins, Susan; Espir, Michael

doi:10.1136/jnnp.32.1.35

Cited by 66 publications

(41 citation statements)

References 6 publications

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“…disorders [6,56,57], while estrogens have been shown to affect immune responses [13] and mast cell secretion [47][48][49][50], For instance, mast cells arc thought to participate in the pathophysiology of vascular headaches [10,54], which are more frequent in women than in men and which may also be associated with food allergy [58,59], Other neuroimmunoendocrine diseases, such as multiple sclero sis, have also been associated with mast cells [11], occur more frequently in females [60,61], and multiple sclerosis patients also have a higher incidence of migraine head aches [62]. Increased numbers of mast cells have also been found in the painful bladder disorder interstitial cystitis [9], as well as in urticaria and angioedema [63], both of which occur more frequently in women.…”

Section: Discussionmentioning

confidence: 99%

Estradiol Augments while Tamoxifen Inhibits Rat Mast Cell Secretion

Vliagoftis

Dimitriadou

Boucher

et al. 1992

Int Arch Allergy Immunol

151

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Mast cells have been studied extensively for their involvement in allergic reactions, where they secrete numerous powerful mediators in response to immunoglobulin E and specific antigens. However, they are also triggered by neuropeptides, they have been found in close contact with neurons, and they are activated in diseases such as angioedema, interstitial cystitis and irritable bowel disease, the prevalence of which is much higher in women. When tested on purified rat peritoneal mast cells, 17β-estradiol augmented secretion of histamine and serotonin, starting at 1 μM and in a dose-dependent manner, whether stimulated by the mast cell secretagogue compound 48/80 or the neuropeptide substance P. However, 17β-estradiol did not augment mast cell secretion stimulated by immunoglobulin E and specific antiserum indicating that immunologic stimulation is under different regulation. Testosterone inhibited secretion induced by compound 48/80. Tamoxifen, an estrogen receptor antagonist used in the treatment of breast cancer, inhibited serotonin and histamine release from purified rat peritoneal mast cells triggered by compound 48/80 or substance P. Tamoxifen also inhibited the increase in intracellular free Ca²⁺ originating from an influx of extracellular Ca²⁺ in response to compound 48/80. Moreover, tamoxifen antagonized the synergistic effect of phorbol myristate and the cation ionophore A23187 on mast cell secretion, suggesting that tamoxifen’s inhibition may be due to regulation of protein kinase C activity. Tamoxifen may, therefore, have a beneficial effect in other neuroimmunoendocrine disorders both through estrogen receptor blockade and inhibition of mast cell secretion.

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Section: Discussionmentioning

confidence: 99%

Estradiol Augments while Tamoxifen Inhibits Rat Mast Cell Secretion

Vliagoftis

Dimitriadou

Boucher

et al. 1992

Int Arch Allergy Immunol

151

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“…Later, other researchers began to explore the relationship between these two clinical abnormalities. All studies have confirmed the association between migraine and MS. 2,5,11,13 Some studies such as studies done by Vecca, Katsiari and Nicoletti did not find any significant relationship between MS and migraine with aura. 11,12,14 Conversely, the very researchers found a significant association between MS and the occurrence of migraine without aura.…”

Section: Discussionmentioning

confidence: 99%

Study relationship between multiple sclerosis and migraine

Ghoreyshi

Fattahzadeh-Ardalani

2016

Int J Res Med Sci

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Background: Each person experiences headaches in his/her life. Some studies have shown a significant relationship between Migraine and MS. In these patients there can be a variety of clinical symptoms such as muscle weakness, sensory loss, ataxia, optic neuritis. Optic neuritis in MS is a relatively common symptom that can cause blurred vision, headaches (especially frontal ones) and painful eye movements. Headache is a clinical symptom that makes people visit neurologists. There are several diagnoses for headaches including migraine. In this study, we evaluated the possibility of a significant relationship between migraine and MS. Methods: In this case-control study, 134 MS patients and 134 sex and age matched controls were selected randomly from all patients referred to hospital. Their information about MS and migraine was collected and analyzed by SPSS v.21. Results: The Mean age of cases in this study was 41.5±9.4 years. The gender of 73.13% of patients was female. In MS patients with chronic headaches, 36 people (42.9%) and in Controls 22 people (38.6%) had migraine. In this study it was found that people with MS, experience more migraine attacks compared to the controls (OR=3 and P=0.05). Further investigation showed that, unlike aura type, migraine without aura had a significant relation with the MS (OR=1.94 and P=0.04). Also, it seems that the number of migraine attacks in patients with MS is significantly more than the controls. Conclusions: Finally it seems that there is a positive association between MS and migraine. The relationship between migraine without aura and MS is obvious, but the relation between aura type and MS is not clear, yet.

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“…However, several other studies have shown a highly variable trend. [2][3][4][5][6][7] We did not collect data regarding current medications, such as beta-interferon therapy or specific headache management drugs, which may influence the course of headache presentation. In order to reduce questionnaire length and encourage participation, headache subtype and stage of MS were not included in the survey.…”

Section: Study Limitationsmentioning

confidence: 99%

“…1 Lifetime prevalence appears to be highly variable, with reports ranging from 4% to 58%. [2][3][4][5][6][7] Despite the inconsistency of prevalence reporting, there is clinical value in the identification of headache incidence in MS patients. 2,8,9 Evidence suggests that headaches may vary based on MS form and lesion location, and MS patients with migraines have a more symptomatic clinical course of the disease.…”

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confidence: 99%

Headache in Multiple Sclerosis

Tabby¹,

Majeed²,

Youngman³

et al. 2013

International Journal of MS Care

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The aim of this study was to investigate the variables affecting headache occurrence in patients with multiple sclerosis (MS). Seventy-two MS patients with comorbid headaches completed a 28-item questionnaire. This evaluation assessed each patient's demographics, headache description and modifying factors, social history, and impact on quality of life. Our patients reported a wide spectrum of headache presentations, characteristics, and resulting disability. We discuss the patterns in our data in the context of current hypotheses regarding headache and MS causality. In our patients, migraines with aura strongly correlated with MS exacerbations, suggesting that they might be useful as a marker for flare-up onset. Patients' pain descriptions varied based on their headache frequency, history, and relationship to MS progression. Due to the severity of headache in MS patients and resulting impact on their activities of daily living, a thorough analysis of headache presentation is warranted in such patients. Int J MS Care. 2013;15:73-80.P eople with multiple sclerosis (MS) have an increased incidence of headaches, although the comorbidity of headaches and MS is poorly understood. 1 Lifetime prevalence appears to be highly variable, with reports ranging from 4% to 58%. [2][3][4][5][6][7] Despite the inconsistency of prevalence reporting, there is clinical value in the identification of headache incidence in MS patients. 2,8,9 Evidence suggests that headaches may vary based on MS form and lesion location, and MS patients with migraines have a more symptomatic clinical course of the disease. 8 In addition, screening patients with MS for headaches has treatment implications. Several medications used to treat MS have been shown to exacerbate headaches, leading to a decreased quality of life and possible treatment nonadherence. 8 Owing to the highly variable presentation of headaches in patients with MS, much remains to be elucidated about the variables affecting headache development. We analyzed a number of factors in relation to headache incidence in a sample of our patients with MS, focusing on headache history, pain description, modifying factors, social history, relation to disease progression, and impact on quality of life.

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Migraine and multiple sclerosis.

Abstract: Migraine is a common condition thought to result from vasomotor changes usually in the distribution of the carotid and vertebro-basilar arteries. According to Kunkle and Wolff (1951)

Cited by 66 publications

References 6 publications

Estradiol Augments while Tamoxifen Inhibits Rat Mast Cell Secretion

Estradiol Augments while Tamoxifen Inhibits Rat Mast Cell Secretion

Study relationship between multiple sclerosis and migraine

Headache in Multiple Sclerosis

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