Migraine as a Disease Associated with Dysbiosis and Possible Therapy with Fecal Microbiota Transplantation

Kappéter, Ágnes; Sipos, Dávid; Varga, Andrea; Vigvári, Szabolcs; Halda-Kiss, Bernadett; Péterfi, Zoltán

doi:10.3390/microorganisms11082083

Cited by 15 publications

(10 citation statements)

References 83 publications

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“…FMT is the transfer of gut microbiota from healthy individuals to patients with gut microbiota disorders, achieving the goal of rebuilding the homeostasis and diversity of the gut microbiota ( Bian et al., 2022 ). In recent years, FMT has shown specific therapeutic effects in diseases such as migraine ( Kappéter et al., 2023 ), CKD ( Liu et al., 2022 ), and Clostridium difficile infection ( Wei et al., 2022 ). After FMT, DN mice showed significant relief of glomerulosclerosis and fibrosis, glomerular injury, basement membrane thickening, and mesangial proliferation, indicating that reconstruction of normal gut microbiota can alleviate DN.…”

Section: Gut Microbiota and Microbial Metabolites As Therapeutic Stra...mentioning

confidence: 99%

Gut microbiota microbial metabolites in diabetic nephropathy patients: far to go

Yu,

Chen,

Zang

et al. 2024

Front. Cell. Infect. Microbiol.

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Diabetic nephropathy (DN) is one of the main complications of diabetes and a major cause of end-stage renal disease, which has a severe impact on the quality of life of patients. Strict control of blood sugar and blood pressure, including the use of renin–angiotensin–aldosterone system inhibitors, can delay the progression of diabetic nephropathy but cannot prevent it from eventually developing into end-stage renal disease. In recent years, many studies have shown a close relationship between gut microbiota imbalance and the occurrence and development of DN. This review discusses the latest research findings on the correlation between gut microbiota and microbial metabolites in DN, including the manifestations of the gut microbiota and microbial metabolites in DN patients, the application of the gut microbiota and microbial metabolites in the diagnosis of DN, their role in disease progression, and so on, to elucidate the role of the gut microbiota and microbial metabolites in the occurrence and prevention of DN and provide a theoretical basis and methods for clinical diagnosis and treatment.

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Section: Gut Microbiota and Microbial Metabolites As Therapeutic Stra...mentioning

confidence: 99%

Gut microbiota microbial metabolites in diabetic nephropathy patients: far to go

Yu,

Chen,

Zang

et al. 2024

Front. Cell. Infect. Microbiol.

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“…The microbiota influences many systems and organs in the human body, including the brain. In migraine pathophysiology, the gut-brain axis plays an important role and gut microbiota are crucial in modulating this link, but the exact mechanisms are unclear [85,86]. This connection suggests that modulating the microbiota could play a significant role in migraine treatment and represents a promising research area [85].…”

Section: Migraine the Gut-brain Axis And Irritable Bowel Syndromementioning

confidence: 99%

“…The gut microbiota, which includes Bacteroides and Firmicutes, is a complex, dynamic system influenced by diet, lifestyle, infections, antibiotic therapy, and hormones [85]. In addition, early life experiences, such as delivery and breastfeeding, are crucial for the development of this complex system [89].…”

Section: Migraine the Gut-brain Axis And Irritable Bowel Syndromementioning

confidence: 99%

“…The gut-brain axis can be affected by dysbiosis, which can contribute to the chronicity of migraine pain by up-regulating TNF-α level in the trigeminal nociceptive system [91]. Microbial dysbiosis may be related to diet, alcohol dependence, smoking, obesity, proton pump inhibitors, selective serotonin reuptake inhibitors, and antibiotic therapy [85].…”

Section: Migraine the Gut-brain Axis And Irritable Bowel Syndromementioning

confidence: 99%

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Migraine Comorbidities

Cuciureanu,

Bistriceanu,

Vulpoi

et al. 2024

Life

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Novel knowledge about the interrelationships and reciprocal effects of migraine and epilepsy, migraine and mood disorders, or migraine and irritable bowel syndrome has emerged in recent decades. Over time, comorbid pathologies associated with migraine that share common physiopathological mechanisms were studied. Among these studied pathologies is epilepsy, a disorder with common ion channel dysfunctions as well as dysfunctions in glutamatergic transmission. A high degree of neuronal excitement and ion channel abnormalities are associated with epilepsy and migraine and antiepileptic drugs are useful in treating both disorders. The coexistence of epilepsy and migraine may occur independently in the same individual or the two may be causally connected. The relationship between cortical spreading depression (CSD) and epileptic foci has been suggested by basic and clinical neuroscience research. The most relevant psychiatric comorbidities associated with migraine are anxiety and mood disorders, which influence its clinical course, treatment response, and clinical outcome. The association between migraine and major depressive disorder can be explained by a robust molecular genetic background. In addition to its role as a potent vasodilator, CGRP is also involved in the transmission of nociception, a phenomenon inevitably linked with the stress and anxiety caused by frequent migraine attacks. Another aspect is the role of gut microbiome in migraine’s pathology and the gut–brain axis involvement. Irritable bowel syndrome patients are more likely to suffer migraines, according to other studies. There is no precise explanation for how the gut microbiota contributes to neurological disorders in general and migraines in particular. This study aims to show that migraines and comorbid conditions, such as epilepsy, microbiota, or mood disorders, can be connected from the bench to the bedside. It is likely that these comorbid migraine conditions with common pathophysiological mechanisms will have a significant impact on best treatment choices and may provide clues for future treatment options.

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“…The use of probiotics as dietary supplements may reduce the frequency and severity of migraine attacks, For instance, a study found that an IgG elimination diet combined with probiotics reduced migraine attack frequency in individuals with migraine and irritable bowel syndrome ( Xie et al., 2019 ). Fecal microbiota transplantation represents a promising approach to treating migraine ( Kappéter et al., 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota and metabolite variations in a migraine mouse model

Wang,

Liu,

Shi

et al. 2024

Front. Cell. Infect. Microbiol.

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Migraine is a prevalent clinical disorder characterized by recurrent unilateral throbbing headache episodes accompanied by symptoms such as nausea, vomiting, photophobia, and phonophobia. Despite its common occurrence, the diagnosis, pathophysiology, and treatment of migraine remain controversial. Extensive research has implicated the gut microbiota in various central nervous system disorders, including anxiety disorders, depression, and Parkinson’s disease. Some studies have also suggested that migraine may stem from disruptions to neurohormones and metabolism. This study aimed to investigate the disparities in gut microbiota and metabolites between migraine mice model and normal mice to shed light on the underlying mechanisms and potential therapeutic approaches. Distinct differences in gut microbial composition were observed between the migraine mouse model and normal mouse, indicating a potential correlation between these variations and the pathogenesis of migraine. This study provides evidence of differences in gut microbiota composition and metabolites between a migraine mouse model and normal mice, which showed that Akkermansiaceae constituted the most abundant taxon in the sham injection mouse group, while Lachnospiraceae constituted the most prevalent group in the migraine mouse model group. The associations between the abundances of Akkermansia muciniphila and Lachnospiraceae bacteria and metabolites suggested their potential roles in the pathogenesis of migraine. The altered abundance of Lachnospiraceae observed in migraine-afflicted mice and its correlations with changes in metabolites suggest that it may affect the host’s health. Thus, probiotic therapy emerges as a possible treatment for migraine. Moreover, significant disparities in gut metabolites were observed between the migraine mouse model and normal mice. These alterations encompass multiple metabolic pathways, suggesting that metabolic disturbances may also contribute to the development of migraines.

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Migraine as a Disease Associated with Dysbiosis and Possible Therapy with Fecal Microbiota Transplantation

Cited by 15 publications

References 83 publications

Gut microbiota microbial metabolites in diabetic nephropathy patients: far to go

Gut microbiota microbial metabolites in diabetic nephropathy patients: far to go

Migraine Comorbidities

Gut microbiota and metabolite variations in a migraine mouse model

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