Migraine Headache Prophylaxis in Adolescents

Fantasia, Heidi Collins

doi:10.1111/1751-486x.12150

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…In addition, topiramate (100 mg/day) was related to modest increases in psychomotor reaction times [38]. Another more serious problem is the potential for suicidal behavior and ideation that has been observed in people taking antiepileptic drugs, including topiramate [39]. Thus, while the pathomechanism of migraine is not completely understood, the choice of medication for personalized therapy tailored to each patient needs to be made cautiously [40].…”

Section: Discussionmentioning

confidence: 99%

Is topiramate effective for migraine prevention in patients less than 18 years of age? A meta-analysis of randomized controlled trials

Wang

et al. 2017

J Headache Pain

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BackgroundMainly based on evidence of success in adults, various medications are commonly used to prevent pediatric migraines. Topiramate has been approved for migraine prevention in children as young as 12 years of age. In this meta-analysis, we aimed to assess the currently published data pertaining to the efficacy of topiramate for migraine prevention in patients less than 18 years of age.MethodsWe searched PubMed/Medline, Embase and the Cochrane Library (from inception to April 2017) for randomized controlled trials (RCTs) published in English. Two independent investigators performed data extraction and quality evaluation using the Cochrane Collaboration’s tool. The data extracted were analyzed by Review Manager 5.3 software.ResultsA total of four RCTs matching the inclusion criteria were included, with an aggregate of 465 patients. Of these patients, 329 were included in the topiramate group, and 136 were included in the placebo group. This meta-analysis revealed that compared with placebo, topiramate failed to decrease the number of patients experiencing a ≥ 50% relative reduction in headache frequency (n = 465, RR = 1.26, 95% CI = [0.94,1.67], Z = 1.55, P = 0.12) or the number of headache days (n = 465, MD = −0.77, 95% CI = [−2.31,0.76], Z = 0.99, P = 0.32) but did reduce PedMIDAS scores (n = 205, MD = −9.02, 95% CI = [−17.34, −0.70], Z = 2.13, P = 0.03). Higher rates of side effects and adverse events in the topiramate group than in the placebo group were observed in the included trials.ConclusionsTopiramate may not achieve a more effective clinical trial endpoint than placebo in the prevention of migraines in patients less than 18 years of age, and topiramate may lead to more side effects or adverse events in the included patients.

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Section: Discussionmentioning

confidence: 99%

Is topiramate effective for migraine prevention in patients less than 18 years of age? A meta-analysis of randomized controlled trials

Wang

et al. 2017

J Headache Pain

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“…There is an increase in plasma levels of calcitonin gene-related peptide (CGRP), a strong vasodilator and marker of trigeminal inflammation, in patients with migraine [ 135 ]. Different factors, like nutritional habits, hormonal diseases, digestive disorders, autoimmune disorders, structural imbalances, mental stress, and lifestyle are involved in the pathology of migraine [ 136 ]. Venlafaxine, beta-blockers, valproate, topiramate, amitriptyline, flunarizine, magnesium, gabapentin, and botulinum toxin type A are used to treat migraine [ 137 ].…”

Section: The Effects Of Lavender On Neurological/neuronal Disordersmentioning

confidence: 99%

Aromatherapy for the brain: Lavender's healing effect on epilepsy, depression, anxiety, migraine, and Alzheimer's disease: A review article

Bavarsad

Bagheri

Kourosh-Arami

et al. 2023

Heliyon

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“…The prevalence of migraine headaches is approximately 10%, 2 to 3 times more common in women than in men, and its highest prevalence is between the ages of 15 and 55. Migraine is recognized as the most common form of chronic headache, with a duration of 4 to 72 hours and pain-free intervals, and sometimes with symptoms before the attack (Fantasia, 2014). Although a single pathophysiology cannot be mentioned in this disease, heredity is involved, and some foods and mental attacks are suggested as triggers (Mirzaei Kotanaei, Shakerinia, & Asghari, 2015).…”

Section: Introductionmentioning

confidence: 99%

The effectiveness of relaxation on quality of life and physical symptoms of military wives with migraine in Tehran

Moazami Goudarzi,

Ahmadi Talokolai,

Vahidi Ghazvini

2023

PWJ

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Objective: The present study aimed to investigate the effectiveness of the psychotherapeutic approach, relaxation, and relaxation in reducing the physical symptoms of migraine headaches and increasing the quality of life of military spouses suffering from migraine in 2022 in Tehran. Method: The statistical population that included women, referring to Hazrat Siddiqa Zahra Hospital located in Tehran, was used. The research design is a pre-test-post-test experiment with a control group, with a sample size of 34 people (17 experimental people and 17 control people) by random sampling method and available. The number of meetings held was 8, and once a week in the clinic. Two questionnaires on quality of life and physical symptoms were used to collect data, and multivariate covariance analysis was used for statistical analysis. Results: The findings showed a significant difference between the average scores of physical symptoms and quality of life of the experimental group and the control group in the post-test (P<0.01). Conclusion: The results showed that physical, mental, and social health, surrounding environment, and quality of life have increased, and physical symptoms have decreased. Based on the results, the relaxation approach can be used as an effective treatment in reducing migraine headaches in women suffering from this disease.

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Migraine Headache Prophylaxis in Adolescents

Cited by 6 publications

References 9 publications

Is topiramate effective for migraine prevention in patients less than 18 years of age? A meta-analysis of randomized controlled trials

Is topiramate effective for migraine prevention in patients less than 18 years of age? A meta-analysis of randomized controlled trials

Aromatherapy for the brain: Lavender's healing effect on epilepsy, depression, anxiety, migraine, and Alzheimer's disease: A review article

The effectiveness of relaxation on quality of life and physical symptoms of military wives with migraine in Tehran

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