Migraine Headache: Updates and Future Developments

Bohm, Parker; Stancampiano, Fernando; Rozen, Todd D.

doi:10.1016/j.mayocp.2018.09.006

Cited by 19 publications

(20 citation statements)

References 27 publications

(34 reference statements)

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“…Migraine manifests with various symptomatology degrees, which makes no stereotypical presentation and further leads to an overdose of prescribed medications [7]. Migraine headaches typically present along with nausea, vomiting, photophobia, and phonophobia [8].…”

Section: Introductionmentioning

confidence: 99%

Is There an Association Between Migraine and Major Depressive Disorder? A Narrative Review

Jahangir¹,

Adjepong²,

Al-Shami³

et al. 2020

Cureus

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Various studies on the association of migraine with depression are published. The comorbidity may upgrade health conditions up to a critical degree. Besides, the duration of symptoms and treatment may be prolonged. Moreover, these conditions can force substantial financial and social hardships on patients and their families. In this literature review, we intend to examine the evidence obtained on the possible associations between migraine and major depressive disorder (MDD). This review is focused on aminergic neurons. One of the variables associated with patients who experience both of these two diseases might have a history of assault. In migraine and MDD patients, genetic evidence, such as single nucleotide polymorphisms (SNP), was found to be one of the associations. Another theory concluded that actual headache diagnosed in patients who received no treatment manifests a history of anxiety, and later, the patients display severe somatic symptoms. In conclusion, there is a robust molecular genetic background, explaining the relationship between migraines and MDD. This correlated data renders a combination of both diagnoses as single separate entities. However, further studies are encouraged to point out the issue of treatment strategies.

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Section: Introductionmentioning

confidence: 99%

Is There an Association Between Migraine and Major Depressive Disorder? A Narrative Review

Jahangir¹,

Adjepong²,

Al-Shami³

et al. 2020

Cureus

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“…Nem specifikus terápia: az alacsonyabb intenzitású vagy mérsékelt krízisek esetén alkalmazhatóak NSAID (nem szteroid gyulladáscsökkentők) orálisan vagy intramuszkulárisan, kábító fájdalomcsillapítók, fájdalomcsillapítók társítva koffeinnel vagy hányáscsillapítókkal [12][13].…”

Section: Orvostudományi éRtesítőunclassified

Chemical and pharmacological characterization of triptans

Kelemen

Bíborka-Erzsébet

Attila

2019

Bulletin of Medical Sciences

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Triptans are specific drugs for migraine attack, their use leads to selective vasoconstriction, while the inflammatory condition that usually occurs during migraine is reduced. The structurally indolamine derivatives are selective agonists of the serotonin 1B/1D receptor. This review presents the history, representatives, production, and physico-chemical properties of triptans, but also discusses their pharmacological properties and mechanism of action.

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“…Except for the common risk factors such as obesity, medication overuse, poor sleep, caffeine and stressful life events, the genetic factors for migraine susceptibility was drawing more and more attention [7,8]. Numerous genetic polymorphisms from meta-analyses of observational studies and GWAS were reported to be associated with migraine susceptibility [9].…”

Section: Introductionmentioning

confidence: 99%

Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses

et al. 2020

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Objective: Numerous genetic variants from meta-analyses of observational studies and GWAS were reported to be associated with migraine susceptibility. However, due to the random errors in meta-analyses, the noteworthiness of the results showing statistically significant remains doubtful. Thus, we performed this field synopsis and re-analysis study to evaluate the noteworthiness using a Bayesian approach in hope of finding true associations. Methods: Relevant meta-analyses from observational studies and GWAS examining correlation between all genetic variants and migraine risk were included in our study by a PubMed search. Identification of noteworthy associations were analyzed by false-positive rate probability (FPRP) and Bayesian false discovery probability (BFDP). Using noteworthy variants, GO enrichment analysis were conducted through DAVID online tool. Then, the PPI network and hub genes were performed using STRING database and CytoHubba software. Results: As for 8 significant genetic variants from observational studies, none of which showed noteworthy at prior probability of 0.001. Out of 47 significant genetic variants in GWAS, 36 were noteworthy at prior probability of 0.000001 via FPRP or BFDP. We further found the pathways "positive regulation of cytosolic calcium ion concentration" and "inositol phosphate-mediated signaling" and hub genes including MEF2D, TSPAN2, PHACTR1, TRPM8 and PRDM16 related to migraine susceptibility. Conclusion: Herein, we have identified several noteworthy variants for migraine susceptibility in this field synopsis. We hope these data would help identify novel genetic biomarkers and potential therapeutic target for migraine.

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Migraine Headache: Updates and Future Developments

Cited by 19 publications

References 27 publications

Is There an Association Between Migraine and Major Depressive Disorder? A Narrative Review

Is There an Association Between Migraine and Major Depressive Disorder? A Narrative Review

Chemical and pharmacological characterization of triptans

Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses

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