Migraine History and Migraine-Induced Stroke in the Dijon Stroke Registry

Sochůrková, Daniela; Moreau, Thibault; Lemesle, M.; Menassa, M.; Giroud, M.; Dumas, R

doi:10.1159/000069411

Cited by 55 publications

(41 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Under normal conditions, CSD in migraine is not believed to damage the brain (13). Migrainous stroke has a reported incidence rate of 0.8/100 000/year and can solitarily not cause the increased rate of stroke in patients with migraine (21). However, possibly patients with migraine and CSD are more vulnerable to damage following ischaemia.…”

Section: Discussionmentioning

confidence: 99%

Diffusion-weighted lesions in acute ischaemic stroke patients with migraine

et al. 2014

View full text Add to dashboard Cite

Objectives -There is increasing knowledge about an association between migraine and ischaemic stroke. Cortical spreading depression (CSD) is the probable biological substrate of migrainous aura. To investigate the influence of CSD on the apparent stroke -migraine association, we hypothesized that magnetic resonance (MR) diffusion weighted images of acute ischaemic stroke patients would reveal an association between small cortical infarctions and migraine. Methods -We included all patients admitted to the Bergen stroke unit between 2006 and 2012 with verified acute ischaemic stroke by MR imaging. Patients were grouped in a migraine and a no-migraine group. Baseline data and clinical characteristics were analysed between the groups. Imaging data were analysed with respect to infarct location and size. Multivariate analyses were performed to adjust for confounders and provide risk estimates for observed associations. Results -A total of 1703 subjects were enrolled, 787 subjects were excluded due to uncertain or unobtainable migraine diagnosis, leaving 196 and 720 subjects in the migraine and nomigraine group, respectively. The migraine group was younger and included a higher proportion of females. There were more infarctions due to cardio-embolism (P = 0.015) and fewer due to small vessel disease (P = 0.018) in the migraine group. A higher rate of patients in the migraine group presented symptoms from the posterior circulation (P = 0.008). Migraine was associated with cortical infarctions (OR 1.8 CI: 1.3-2.5, P = 0.001). Migraine was also associated with small infarctions (OR 1.9 CI: 1.04-3.5, P = 0.038). Conclusions -Migraine was associated with small cortical infarctions. This association may be due to cortical spreading depression.

show abstract

Section: Discussionmentioning

confidence: 99%

Diffusion-weighted lesions in acute ischaemic stroke patients with migraine

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Clinical studies report an incidence of 0.5-1.5% of all ischaemic strokes and of 10-14% of strokes in young patients [6][7][8][9]. According to the criteria of the International Headache Society (IHS) [10], a migrainous infarction occurs during a migraine attack, in a patient with migraine with aura, which is typical of previous attacks except that one or more aura symptoms persist for more than 60 min.…”

Section: Migrainous Infarctionmentioning

confidence: 99%

From migraine to stroke

Katsarava¹,

Rabe²,

Diener³

2008

Intern Emerg Med

View full text Add to dashboard Cite

An association between migraine and ischemic stroke has been observed for many years but the exact mechanisms by which migraine can lead to stroke are currently still under investigation. Migraine seems to affect neurovascular factors and substances that increase the risk of stroke during and in between migraine attacks. Ischemic stroke can occur as a complication of an attack of migraine with aura. Epidemiological studies suggest that vascular risk factors are increased in migraineurs, thus increasing the incidence of stroke. Another important issue is a patent foramen ovale (PFO), which is a well-known risk factor for stroke and which, on the other hand, seems to be more frequent in migraineurs than in people without. The purpose of this review is to summarize the current literature linking the two neurological diseases: migraine and stroke.

show abstract

“…• In the brain, spreading depression -which is linked to migraines [59] and ischemic stroke [60] -is driven by regenerative potassium waves where the potassium is released from cells and diffusion is across the extracellular space. The details of the extracellular space create small "compartments" that have low levels of molecules that need to be addressed stochastically.…”

Section: Chapter 7 Conclusionmentioning

confidence: 99%

Parallel Stochastic Discrete Event Simulation of Calcium Dynamics in Neuron

Patoary

Tropper

McDougal

et al. 2019

IEEE/ACM Trans. Comput. Biol. and Bioinf.

View full text Add to dashboard Cite

the correctness and performance of NTW by comparing it to a sequential deterministic simulation in NEURON. The derivation of a discrete event calcium wave model using the stochastic IP 3 R structure is one of my main scientific contributions of this thesis. This newly derived stochastic discrete event calcium wave model is described in chapter-5. In high performance issue, a dynamic load balancing algorithm and a dynamic window control algorithm for NTW was also developed for the stochastic calcium wave model. We use Q-learning to determine the basic control parameters of the algorithm. Prof. Tropper motivated me to employ Q-learning to optimize the performance of NTW in calcium wave simulation. Developing such an intelligent dynamic load balancing algorithm with dynamic window control is another research contribution of this thesis. All algorithms are described in chapter 6. vi ABSTRACTThe intra-cellular calcium signaling pathways of a neuron depends on both biochemical reactions and diffusions. Some quasi-isolated compartments (e.g. spines) are so small and the calcium concentrations are so low that one molecule diffusing into the compartment can make a nontrivial difference in calcium concentration. Such events can affect dynamics discretely in such a way that they cannot be evaluated by a deterministic simulation. Stochastic models of such a system provide a more detailed understanding of these systems than existing deterministic models because they capture their behavior at a molecular level. My research focuses on the development of a high performance parallel discrete event simulation environment, NTW , which is intended for use in the parallel simulation of stochastic reaction-diffusion systems such as intra-cellular calcium signaling. We make use of two models, a calcium buffer model and a calcium wave model. The calcium buffer model is employed in order to verify the correctness and performance of NTW by comparing it to a sequential deterministic simulation in NEURON. NEURON is a framework for simulating neurons which is used by neuroscientists world-wide. Our work is part of the NEURON project and has the long term goal of developing a multiscale simulation for large scale neuronal networks. We derived a discrete event calcium wave model from a deterministic model using the stochastic inositol 1,4,5-trisphosphate receptors, IP 3 R, structure. A dynamic load balancing algorithm and a dynamic window control algorithm for NTW was also developed for the stochastic calcium wave model.We make use of Q-learning to determine the basic control parameters of the algorithm.

show abstract

Migraine History and Migraine-Induced Stroke in the Dijon Stroke Registry

Cited by 55 publications

References 20 publications

Diffusion-weighted lesions in acute ischaemic stroke patients with migraine

Diffusion-weighted lesions in acute ischaemic stroke patients with migraine

From migraine to stroke

Parallel Stochastic Discrete Event Simulation of Calcium Dynamics in Neuron

Contact Info

Product

Resources

About