Migraine in childhood – are periodically occurring migraine attacks related to dynamic changes of cortical information processing?

Siniatchkin, Michael; Kropp, Peter; Gerber, Wolf‐Dieter; Stephani, Ulrich

doi:10.1016/s0304-3940(99)00924-6

Cited by 53 publications

(64 citation statements)

References 12 publications

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“…In migrainous child-parent pairs, habituation of evoked potentials has a clear familial pattern. 66,71 Moreover, in asympto matic individuals who have a first degree relative with migraine, and are thus at risk of developing migraine during their lifetime, cortical evoked potentials 79 and nociceptive blink reflexes 86 (nBRs, discussed under processing of noxious stimuli below) showed amplitude and habituation abnormalities similar to those found interictally in people with migraine.…”

Section: Possible Mechanisms Of Habituationmentioning

confidence: 92%

“…During the days preceding an attack, CNV and P300 habituation is minimal, and the ampli tude of these responses is maximal. 70,71 Within the 12-24 h immediately preceding an attack, and during the attack, habituation of evoked potentials normalizes. This pattern has been shown for CNV, 36,70,71 VEP, 57,72 and SSEP 61 amplitudes, and for visual P300 latency.…”

Section: Episodic Migrainementioning

confidence: 99%

“…70,71 Within the 12-24 h immediately preceding an attack, and during the attack, habituation of evoked potentials normalizes. This pattern has been shown for CNV, 36,70,71 VEP, 57,72 and SSEP 61 amplitudes, and for visual P300 latency. 73 The R2 component recorded during blink reflexes-evoked by an electrical stimulus delivered with a classic non nociceptive surface electrode-showed a habituation deficit in patients before a migraine attack, 76 although in another study only slight habituation abnormalities were found interictally.…”

Section: Episodic Migrainementioning

confidence: 99%

“…Nonetheless, various experimen tal data suggest some interesting avenues for further research. For instance, cortical responsivity is cyclic in individuals with migraine, 71 and varies in parallel with changes in platelet serotonin content. 73 The period icity of neurophysiological brain activity might also be related to psychophysical, genetic 66,79 or metabolic factors, 80 or to the biorhythms of hypothalamic activity.…”

Section: Episodic Migrainementioning

confidence: 99%

“…Interestingly, the habituation deficit reappears when patients evolve from chronic to episodic migraine. 83 Since the response pattern in chronic migraine is indistinguishable from that observed during migraine attacks, 43,[51][52][53][54][55][56][57][58][59][60][61][62][70][71][72] our research group has suggested that patients with chronic migraine are locked in an ictal like state. 84 The most prevalent factor associated with the tran sition from episodic to chronic migraine is acute medication overuse.…”

Section: Chronic Migrainementioning

confidence: 99%

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Altered processing of sensory stimuli in patients with migraine

et al. 2014

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| Migraine is a cyclic disorder, in which functional and morphological brain changes fluctuate over time, culminating periodically in an attack. In the migrainous brain, temporal processing of external stimuli and sequential recruitment of neuronal networks are often dysfunctional. These changes reflect complex CNS dysfunction patterns. Assessment of multimodal evoked potentials and nociceptive reflex responses can reveal altered patterns of the brain's electrophysiological activity, thereby aiding our understanding of the pathophysiology of migraine. In this Review, we summarize the most important findings on temporal processing of evoked and reflex responses in migraine. Considering these data, we propose that thalamocortical dysrhythmia may be responsible for the altered synchronicity in migraine. To test this hypothesis in future research, electrophysiological recordings should be combined with neuroimaging studies so that the temporal patterns of sensory processing in patients with migraine can be correlated with the accompanying anatomical and functional changes.

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Section: Possible Mechanisms Of Habituationmentioning

confidence: 92%

Section: Episodic Migrainementioning

confidence: 99%

Section: Episodic Migrainementioning

confidence: 99%

Section: Episodic Migrainementioning

confidence: 99%

Section: Chronic Migrainementioning

confidence: 99%

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Altered processing of sensory stimuli in patients with migraine

et al. 2014

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Role of neurophysiology in the clinical practice of primary pediatric headaches

Raieli

Puma

Brighina

2007

Drug Development Research

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The role of electrophysiological studies in pediatric headaches is controversial. In childhood headaches, neurophysiological examinations are of interest for potential clinical use because they are noninvasive and are scarcely influenced by environmental factors or drug use. Electrophysiological studies in childhood headache principally explored the role of electroencephalographic (EEG) evaluations in migraine, while less evidence has been reported about other neurophysiological techniques, such as evoked potentials, event-related potentials, and, less often, transcranial magnetic stimulation. In this brief review, we point out our attention to the aid of neurophysiological methods in the clinical diagnosis of pediatric headaches. Although many examinations are actually of little value in the clinical setting, they may have a potential role in some clinical subgroups or in monitoring and evaluating the effects of pharmacological treatment. Drug Dev Res 68: 389-396, 2007. r

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