Migraine treatment and the risk of postoperative, pain-related hospital readmissions in migraine patients

Platzbecker, Katharina; Timm, Fanny P.; Ashina, Sait; Houle, Timothy T.; Eikermann, Matthias

doi:10.1177/0333102420949857

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…This study reinforces that our theory is an effective and low-cost treatment option (Platzbecker et al, 2020 ) compared with pharmaceutical treatments which are available but expensive (Martelletti et al, 2018 ).…”

Section: Discussionsupporting

confidence: 85%

Management of auricular transcutaneous neuromodulation and electro-acupuncture of the vagus nerve for chronic migraine: a systematic review

Fernández-Hernando,

Fernández-de-las-Peñas,

Pareja-Grande

et al. 2023

Front. Neurosci.

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BackgroundMigraine is a type of primary headache that is accompanied by symptoms such as nausea, vomiting, or sensitivity to light and sound.ObjectiveThe aim of this study was to conduct a systematic review on the effectiveness of non-invasive neuromodulation, auricular transcutaneous vagus nerve stimulation (at-VNS), and electro-ear acupuncture of the vagus nerve in patients with migraine headaches.MethodsSix databases were searched from inception to 15 June 2022 for clinical trials, in which at least one group received any form of non-invasive neuromodulation of the vagus nerve for managing migraine with outcomes collected on pain intensity and related disability. Data, including participants, interventions, blinding strategy, outcomes, and results, were extracted by two reviewers. The methodological quality was assessed with the PEDro scale, ROB, and Oxford scale.ResultsThe search identified 1,117 publications with nine trials eligible for inclusion in the review. The methodological quality scores ranged from 6 to 8 (mean: 7.3, SD: 0.8) points. Low-quality evidence suggests some positive clinical effects for the treatment of chronic migraine with 1 Hz with at-VNS and ear-electro-acupuncture compared with the control group at post-treatment. Some of the studies provided evidence of the relationship between chronic migraine and a possible positive effect as a treatment with at-VNS and the neurophysiological effects using fMRI. Six of the studies provided evidence using fMRI of the relationship between chronic migraine and a possible positive effect as a treatment with at-VNS and the neurophysiological effects. Regarding all included studies, the level of evidence with the Oxford scale was level 1 (11.17%), six studies were graded as level 2 (66.66%), and two studies were graded as level 3 (22.2%). With the PEDro score, five studies got a low methodological score < 5 and only four got a score superior to 5, being highly methodological quality studies. For ROB, most of the studies were high risk and only a few of them received a low risk of bias. The pain intensity, migraine attacks, frequency, and duration were measured by three studies with positive results at post-treatment. And only 7% reported adverse events using at-VNS. All studies reported results at a post-treatment period in their respective main outcomes. And all studies with fMRI provided strong evidence of the relationship between the Locus Coeruleus, Frontal Cortex, and other superior brain areas with the auricular branch of the Vagus nerve with at-VNS.ConclusionSome positive effects regarding the effect of non-invasive neuromodulation, auricular transcutaneous vagus nerve stimulation (at-VNS), and electro-ear acupuncture of the vagus nerve on migraine is reported in the current literature, but there are not enough data to obtain strong conclusions.Systematic review registrationThis systematic review was registered in the PROSPERO database (registration number: CRD42021265126).

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Section: Discussionsupporting

confidence: 85%

Management of auricular transcutaneous neuromodulation and electro-acupuncture of the vagus nerve for chronic migraine: a systematic review

Fernández-Hernando,

Fernández-de-las-Peñas,

Pareja-Grande

et al. 2023

Front. Neurosci.

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show abstract

“…This review supports our theory that non-invasive vagus nerve stimulation (n-VNS) is a cost-effective and beneficial treatment option [37]. Compared to current pharmaceutical treatments that are often costly, this alternative approach offers a cost-effective solution [38].…”

Section: Discussionsupporting

confidence: 66%

Effects of Non-Invasive Neuromodulation of the Vagus Nerve for the Management of Cluster Headache: A Systematic Review

Fernández-Hernando,

Justribó Manion,

Pareja

et al. 2023

JCM

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Background: Cluster headache (CH) is a type of headache that has a global prevalence of 0.5–3/1000 people, provokes severe, strictly unilateral pain through the first branch of the trigeminal nerve, and is associated with observable autonomous responses. CH provokes intense pain and decreases quality of life. Objective: In this study, we aimed to carry out a systematic review of the effectiveness of non-invasive neuromodulation of the vagus nerve in patients with cluster headaches, which was registered on PROSPERO No. CRD42021265126. Methods: Six databases were used from their date of inception to February 2023 to obtain studies with the group intervention of non-invasive neuromodulation of the vagus nerve for cluster headache, with outcomes based on pain attacks, duration, and disabilities. Data on the subjects, group intervention, main outcomes, and results were collected by two authors. Results: The search provided 1003 articles, with three clinical trials being eligible for inclusion in the review. The methodological quality scores ranged from 6 to 8 points (mean: 7.3, SD: 0.8) out of a maximum of 10 points. The post-treatment results showed some positive effects using n-VNS as a treatment for cluster headache, more specifically regarding cervical neuromodulation of the vagus nerve. Conclusions: The systematic review found moderate-to-high-quality evidence supporting that n-VNS and cervical n-VNS may have some positive effects at the end of the treatment being effective to relieve the frequency and intensity of cluster headaches. The poor quantity of studies available and the lack of homogeneity in the study protocols did not allow the pooling of data for a meta-analysis.

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Incidence and Factors Associated with Postoperative Headache among Adult Elective Surgical Patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2022

Zegeye,

Ahmed,

Aytolign

et al. 2024

Preprint

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Background Postoperative headache is a medical condition that has a strong association with future recurrent and chronic headache, higher morbidity and mortality, extended hospital stays, poor quality of life and high financial burden. Despite, having these consequences, there are limited studies regarding the incidence and associated factors of postoperative headache. Objective The objective of this study was to assess the incidence and associated factors of postoperative headache among adult elective surgical patients at University of Gondar Comprehensive Specialized Hospital Northwest Ethiopia, April 9 to 20 June 2022. Methods An institution -based follow- up study was conducted from April 9 to June 20 2022, at University of Gondar Comprehensive Specialized Hospital, after approval of ethical committee, Consecutively 424 patients were included. Postoperative headache was measured based on patient interview and the response was dichotomized as present or absent. Data were collected through chart review as well as patient interviews using a questionnaire. Data entered in to epidata 4.6.0 and statistical analysis was performed using stata version 14.01 software. Descriptive statistics was conducted to summarize patient’s information and to determine the incidence of postoperative headache. Binary logistic regression was conducted to identify factors associated with postoperative headache. Variables with P-value < 0.05 were considered statistically significant. Results The overall incidence of postoperative headache in the first three postoperative days was 54.3% and the response rate was 99%. Previous history of headache (AOR = 4.83, CI = 2.42 9.73), prolonged fasting (AOR = 2.28, CI = 1.44–3.60), general anesthesia (AOR = 1.96, CI = 1.25 3.07), intraoperative hypotension (AOR = 1.74, CI = 1.06–2.88), female gender (AOR = 1.62,CI = 1.06–2.54) and caffeine consumption(AOR = 1.60,CI = 1.02–2.52) were significantly associated with postoperative headache and most of patients (39%) were experienced moderate headache Conclusion and recommendations: According to the findings of our study, more than half of surgical patients suffered from postoperative headache. Use of general anesthesia techniques, having history of headache, being female, intraoperative hypotension, caffeine consumption and having prolonged preoperative fasting were strongly associated with postoperative headache. The problem needs regular assessment and treatment.

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Migraine treatment and the risk of postoperative, pain-related hospital readmissions in migraine patients

Cited by 3 publications

References 32 publications

Management of auricular transcutaneous neuromodulation and electro-acupuncture of the vagus nerve for chronic migraine: a systematic review

Management of auricular transcutaneous neuromodulation and electro-acupuncture of the vagus nerve for chronic migraine: a systematic review

Effects of Non-Invasive Neuromodulation of the Vagus Nerve for the Management of Cluster Headache: A Systematic Review

Incidence and Factors Associated with Postoperative Headache among Adult Elective Surgical Patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2022

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