Migräneprophylaxe mit einem Probiotikum

Straube, Andreas; Müller, Hilke; Stiegelbauer, Verena; Frauwallner, Anita

doi:10.1007/s15006-018-1052-5

Cited by 10 publications

(8 citation statements)

References 12 publications

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“…The results showed a predominance in adults, similar to other studies on the incidence and prevalence of migraine 18,21,22 . When compared to other chronic conditions, due to the difficulty of performing daily activities because of pain, migraine patients have significant limitations in the quality of life in relation to the healthy population.…”

Section: Discussionsupporting

confidence: 90%

Association between migraine, constipation and lactose intolerance in adults patients

Souza

Leite

Nepomuceno

2020

Brazilian Journal of Pain

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BACKGROUND AND OBJECTIVES:Considering the bidirectional connection between intestine and brain, the present study examined the association between migraine, lactose intolerance, and intestinal constipation in patients with status migrainosus. METHODS: This is a cross-sectional retrospective study that included 97 patients aged 20 years or older. The impact of pain was assessed by the Migraine Disability Assessment and the Headache Impact Test-6 questionnaires. The pain intensity was measured by the visual analog scale. Chi-square and Student-t tests were used for the statistical analysis. RESULTS:The sample consisted of 88.7% women, 56.8% overweight, 76.3% sedentary, 32% constipated and 23.7% lactose intolerant. Higher pain intensity (8.9±1.3) and impact pain mean was assessed by the Headache Impact Test-6 (67.6±5.3) and the Migraine Disability Assessment (36.7±26.3) in constipated patients compared to those without constipation. Lactose-intolerant patients presented higher migraine mean time (19.9±14.2) compared to lactose tolerant patients. Constipated and lactose intolerant patients presented higher prevalence of overweight (58.1 and 65.2%) and abdominal obesity (70.0 and 68.2%) compared to non-constipated and lactose tolerant patients, respectively. CONCLUSION: Although were observed in the evaluated sample a considerable prevalence of constipation and lactose intolerance, higher mean scores in the questionnaires used for pain impact and intensity in constipated patients and longer migraine diagnosis time in those with lactose-intolerance, there was no statistical significance in the association between migraine and these two gastrointestinal disorders.

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Section: Discussionsupporting

confidence: 90%

Association between migraine, constipation and lactose intolerance in adults patients

Souza

Leite

Nepomuceno

2020

Brazilian Journal of Pain

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“…Recent reports demonstrate an increased frequency of gastrointestinal disorders, such as Helicobacter pylori infection, IBS, gastroparesis, hepatobiliary disorders, celiac disease, and alterations in the microbiota have been linked to the occurrence of migraine (Camara-Lemarroy et al, 2016). However, several case-control studies based on probiotic treatment have different conclusions (de Roos et al, 2017;Straube et al, 2018). Up to now, the precise characteristics and changes of gut microbiome in migraine were not fully elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…The fact that both IBD and IBS are severe gut disorders associated with gut permeability and inflammation caused by gut microbes through the gutbrain axis (Aggarwal et al, 2012) suggests an important role of gut bacteria in migraine. In an uncontrolled observational study on 1,020 patients, researchers found that multispecies probiotic formulations can reduce the intensity and the frequency of migraine attacks (Straube et al, 2018). However, another randomized placebo-controlled study conducted on 63 patients showed that the use of multispecies probiotics, compared with placebo, does not significantly affect intestinal permeability or inflammation (de Roos et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Both the ketogenic diet (Gross et al, 2019) and the traditional Chinese medicinal plant Gastrodia elata, which is also used as food in China (Hua et al, 2019), have been reported to regulate gut microbiota and to promote remission from migraine. The few publications available, which are based on probiotic treatment, however, are with different conclusions about the effects of probiotics on migraine in humans (de Roos et al, 2017;Straube et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine

Chen

Wang

et al. 2020

Front. Cell. Infect. Microbiol.

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Migraine is a very common, multifactorial, and recurrent central nervous system disorder that causes throbbing headache, photophobia, phonophobia, nausea, and disability. Migraine occurs more often in females, and its complex physiopathology is not yet fully understood. An increasing number of gastrointestinal disorders have been linked to the occurrence of migraine suggesting that gut microbiota might play a pivotal role in migraine through the gut-brain axis. In the present work, we performed a metagenome-wide association study (MWAS) to determine the relationship between gut microbiota and migraine by analyzing 108 shotgun-sequenced fecal samples obtained from elderly women who suffer from migraine and matched healthy controls. Notably, the alpha diversity was significantly decreased in the migraine group at species, genus, and Kyoto Encyclopedia of Genes and Genomes (KEGG) orthologous levels. Firmicutes, especially the "unfriendly" Clostridium spp., were significantly enriched in the migraine group. Conversely, the healthy controls held more beneficial microorganisms, such as Faecalibacterium prausnitzii, Bifidobacterium adolescentis, and Methanobrevibacter smithii. For functional modules, the migraine group was enriched in gut-brain modules (GBMs) including kynurenine degradation and γ-aminobutyric acid (GABA) synthesis. However, the healthy controls held higher gut metabolic modules (GMMs) including glycolysis, homoacetogenesis, and GBMs including quinolinic acid degradation and S-adenosyl methionine (SAM) synthesis. The differences in gut microbiota composition and function between the migraine and healthy groups provided new information as well as novel therapeutic targets and strategies for migraine treatment, which could help to improve the early diagnosis of the disease, as well as the long-term prognosis and the life quality of patients suffering from migraine.

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“…Two recent reviews report an increased frequency of gastrointestinal (GI) symptoms or disorders in migraine patients compared to the general population, such as increased rates of nausea, cyclic vomiting syndrome, inflammatory bowel syndrome, irritable bowel syndrome, celiac disease, gastroparesis, hepatobiliary disorders, helicobacter pylori infection, gastric stasis, and alterations in the microbiota [208,209,210]. While there was no evidence for an added benefit of probiotics in an RCT with 63 episodic migraineurs [211] an uncontrolled observational study with 1020 patients using a multispecies probiotic showed a significant reduction in migraine days, headache intensity and the use of painkillers [212]. Additionally, an immunoglobulin-G based elimination diet among migraine patients with irritable bowel syndrome was associated with significant reductions in attack frequency, duration, severity and medication use [213].…”

Section: Potentially Migraine Relevant Mechanisms Of Ketosismentioning

confidence: 99%

Potential Protective Mechanisms of Ketone Bodies in Migraine Prevention

et al. 2019

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An increasing amount of evidence suggests that migraines are a response to a cerebral energy deficiency or oxidative stress levels that exceed antioxidant capacity. The ketogenic diet (KD), a diet mimicking fasting that leads to the elevation of ketone bodies (KBs), is a therapeutic intervention targeting cerebral metabolism that has recently shown great promise in the prevention of migraines. KBs are an alternative fuel source for the brain, and are thus likely able to circumvent some of the abnormalities in glucose metabolism and transport found in migraines. Recent research has shown that KBs—D-β-hydroxybutyrate in particular—are more than metabolites. As signalling molecules, they have the potential to positively influence other pathways commonly believed to be part of migraine pathophysiology, namely: mitochondrial functioning, oxidative stress, cerebral excitability, inflammation and the gut microbiome. This review will describe the mechanisms by which the presence of KBs, D-BHB in particular, could influence those migraine pathophysiological mechanisms. To this end, common abnormalities in migraines are summarised with a particular focus on clinical data, including phenotypic, biochemical, genetic and therapeutic studies. Experimental animal data will be discussed to elaborate on the potential therapeutic mechanisms of elevated KBs in migraine pathophysiology, with a particular focus on the actions of D-BHB. In complex diseases such as migraines, a therapy that can target multiple possible pathogenic pathways seems advantageous. Further research is needed to establish whether the absence/restriction of dietary carbohydrates, the presence of KBs, or both, are of primary importance for the migraine protective effects of the KD.

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Migräneprophylaxe mit einem Probiotikum

Cited by 10 publications

References 12 publications

Association between migraine, constipation and lactose intolerance in adults patients

Association between migraine, constipation and lactose intolerance in adults patients

Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine

Potential Protective Mechanisms of Ketone Bodies in Migraine Prevention

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