Migrant populations and the incidence of Type 1 diabetes mellitus: an overview of the literature with a focus on the Spanish-heritage countries in Latin America

Serrano-Rı́os, Manuel; Goday, Albert; Larrad, Teresa Martìnez

doi:10.1002/(sici)1520-7560(199903/04)15:2<113::aid-dmrr25>3.0.co;2-i

Cited by 38 publications

(28 citation statements)

References 86 publications

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“…Migration studies also support a role for environmental factors influencing disease incidence (3,5). Type 1 diabetes incidence in Asian children who migrated to Britain increased from 3.1/100,000 per year in 1978 -1981 to 11.7/ 100,000 per year in 1988 -1990, much higher than in their native Karachi (1/100,000 per year) (24,25).…”

Section: Age-dependent Role For Nongenetic Factorsmentioning

confidence: 94%

Age-Dependent Influences on the Origins of Autoimmune Diabetes

Leslie

Castelli

2004

Diabetes

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Section: Age-dependent Role For Nongenetic Factorsmentioning

confidence: 94%

Age-Dependent Influences on the Origins of Autoimmune Diabetes

Leslie

Castelli

2004

Diabetes

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“…Glycaemia was measured in tail vein blood using a glucometer (Glucocard, Menarini, Florence, Italy) before and after (5,15,30,60 and 120 min) an intra-peritoneal injection of 3 g D (+) glucose monohydrate/kg BW, dissolved in sterile PBS.…”

Section: Intra-peritoneal Glucose Tolerance Test (Ipgtt)mentioning

confidence: 99%

“…Candidates can be sought in diet, lifestyle, viral infections, but the clear northsouth gradient in prevalence of this and other autoimmune diseases in Europe has often suggested a role for sunlight as a modulator of autoimmunity [3,4]. Also the observation that children with completely different genetic backgrounds often convert to the diabetes incidence of the country they live in, suggests that an environmental factor is involved [5,6].…”

mentioning

confidence: 99%

Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice

et al. 2004

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Aims/hypothesis. 1,25-dihydroxyvitamin D 3 , the active form of vitamin D, prevents Type 1 diabetes in non-obese diabetic (NOD) mice. Epidemiological data show a threefold increase in human Type 1 diabetes when vitamin D deficiency was present in the first months of life. To evaluate whether a similar dietary deficiency affects diabetes incidence in NOD mice, we generated NOD mice with vitamin D deficiency in early life. Methods. Breeding pairs of NOD mice, as well as their offspring (test mice), were kept in surroundings devoid of ultraviolet light and were fed a vitamin Ddepleted diet for 100 days. Mice were followed for 250 days. Results. At 250 days, 35% (12/35) male and 66% (22/33) female vitamin D-deficient mice were diabetic compared to 15% (6/40, p=0.05) and 45% (13/29, p<0.01) of the control mice. At 100 days no difference in insulitis was seen, but more vitamin D-deficient mice were glucose intolerant. Higher IL1 expression was detected in islets of vitamin D-deficient mice and their peritoneal macrophages had an aberrant cytokine profile (low IL1 and IL6, high IL15). Thymus and lymph nodes of vitamin D-deficient mice contained less CD4 + CD62L + cells. Conclusion/interpretation. Vitamin D status increases the expression of Type 1 diabetes in NOD mice. Our data in NOD mice, as well as human epidemiological data, point to the importance of preventing vitamin D deficiency in early childhood. Controlling this dietary factor could be an easy and safe way to reduce the incidence of Type 1 diabetes in subjects who are genetically at risk. [Diabetologia (2004)

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“…LA is characterized by low to moderate T1D incidences depending on the observed country [8] and by a universal admixture in which the relative contributions of African, European, and Amerindian gene pools vary in accordance with historical circumstances [10]. LA is a heterogeneous population in which the Spanish-Mestizo population varies from 60% to 80% in Mexico, Colombia, Venezuela, Paraguay, Chile, Peru, and Ecuador to less than 15% in Uruguay and Argentina [11]. So far, however, few populations in LA, such as Mexicans and Mexican-Americans, have participated in worldwide analyses of this topic [9,12]; despite that, there are isolated studies from other countries in which moderate genetic associations could be detected by a meta-analysis, even though some of them have low power samples [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%