Migration and cardiovascular disease risk among Ghanaian populations in Europe: The RODAM study.

Boateng, Daniel; Agyemang, Charles; Beune, Erik; Smeeth, Liam; Schulze, M; Addo, Juliet; Aikins, Ama de Graft; Galbete, Cecilia; Agyei‐Baffour, Peter; Kengne, A.P.; Grobbee, D. E.; Stronks, Karien; Klipstein‐Grobusch, Kerstin

doi:10.1093/eurpub/ckw170.028

Cited by 10 publications

(15 citation statements)

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“…Among marginalised women, with reference to province 3, province 2 had higher odds while province 7 had lower odds of delivering at home. Province 2 includes 8 Terai districts from Southern Nepal which are largely inhabited by the marginalised ethnic population -"Madheshi" [44]. Previous studies showed that access to family planning services, ANC, and use of SBAs during deliveries was lower among the Terai dalit and janajati in comparison to other ethnic groups [11,16].…”

Section: Discussionmentioning

confidence: 99%

Determinants of home delivery in Nepal – A disaggregated analysis of marginalised and non-marginalised women from the 2016 Nepal Demographic and Health Survey

et al. 2020

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Conclusion We conclude that poor education, poor economic status, non-completion of four ANC visits and belonging to Province 2 particularly determined either group of women to deliver at home, whereas residing in rural areas, living far from health facility, and belonging to Province 7 determined marginalised women to deliver at home. Preventing mothers from delivering at home would thus require focusing on specific geographical areas besides considering wider socioeconomic determinants.

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Section: Discussionmentioning

confidence: 99%

Determinants of home delivery in Nepal – A disaggregated analysis of marginalised and non-marginalised women from the 2016 Nepal Demographic and Health Survey

et al. 2020

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“…In migrants, there is a higher T2D prevalence, the age of onset is younger and complications are more severe. One of the main determinants of T2D is obesity, which also disproportionally affects migrants [146–149 ]. In rural Ghanaians, most T2D is independent of obesity [150 ] (Fig.…”

Section: Introductionmentioning

confidence: 99%

Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies

Bousquet

Cristol

Czarlewski³

et al. 2020

Clin Transl Allergy

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There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.

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“…66 Despite having higher sitting height among the migrant population, previous analysis in this population showed a less beneficial CVD risk factor profile and estimated CVD risk especially among men in the migrants compared to the home population. 4,5 Most chronic diseases including CVDs are seen as an interaction between environmental factors, such as diet and one's genetic susceptibility. Although a homogeneous African population may have similar early-life exposures, upon moving to an urbanized setting, there is an exposure to a larger variation in lifestyle, diet, and the entire societal context, 67 which determines gene-environment interactions and subsequent CVD developments in adulthood.…”

Section: Discussionmentioning

confidence: 99%

“…CVD risk ≥ 7.5% was considered as an "elevated" risk of CVD based on the prior work by Goff et al 29 The distribution of estimated 10-year ASCVD risk between Ghanaian migrant and home populations has been shown in previous analyses. 5,36 Current guidelines for CVD risk reduction have emphasized the need to assess all risk factors as a more effective basis to deliver CVD prevention interventions. 37 Absolute CVD risk estimates, using established risk algorithms, help to determine the probability of a cardiovascular event occurring within a specified time horizon.…”

Section: Estimated 10-year Cvd Riskmentioning

confidence: 99%

Early-life exposures and cardiovascular disease risk among Ghanaian migrant and home populations: the RODAM study

Boateng

Said‐Mohamed

Smeeth

et al. 2019

J Dev Orig Health Dis

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Early-life environmental and nutritional exposures are considered to contribute to the differences in cardiovascular disease (CVD) burden. Among sub-Saharan African populations, the association between markers of early-life exposures such as leg length and sitting height and CVD risk is yet to be investigated. This study assessed the association between leg length, sitting height, and estimated 10-year atherosclerotic cardiovascular disease (ASCVD) risk among Ghanaian-born populations in Europe and Ghana. We constructed sex-specific quintiles for sitting height and leg length for 3250 participants aged 40–70 years (mean age 52 years; men 39.6%; women 60.4%) in the cross-sectional multicenter Research on Diabetes and Obesity among African Migrants study. Ten-year risk of ASCVD was estimated using the Pooled Cohort Equations; risk ≥7.5% was defined as “elevated” CVD risk. Prevalence ratios (PR) were estimated to determine the associations between sitting height, leg length, and estimated 10-year ASCVD risk. For both men and women, mean sitting height and leg length were highest in Europe and lowest in rural Ghana. Sitting height was inversely associated with 10-year ASCVD risk among all women (PR for 1 standard deviation increase of sitting height: 0.75; 95% confidence interval: 0.67, 0.85). Among men, an inverse association between sitting height and 10-year ASCVD risk was significant on adjustment for study site, adult, and parental education but attenuated when further adjusted for height. No association was found between leg length and estimated 10-year ASCVD risk. Early-life and childhood exposures that influence sitting height could be the important determinants of ASCVD risk in this adult population.

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Migration and cardiovascular disease risk among Ghanaian populations in Europe: The RODAM study.

Cited by 10 publications

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Determinants of home delivery in Nepal – A disaggregated analysis of marginalised and non-marginalised women from the 2016 Nepal Demographic and Health Survey

Determinants of home delivery in Nepal – A disaggregated analysis of marginalised and non-marginalised women from the 2016 Nepal Demographic and Health Survey

Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies

Early-life exposures and cardiovascular disease risk among Ghanaian migrant and home populations: the RODAM study

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