Migration and diversification of the vagal neural crest

Hutchins, Erica J.; Kunttas, Ezgi; Piacentino, Michael L.; Howard, Aubrey G.A.; Bronner, Marianne E.; Uribe, Rosa A.

doi:10.1016/j.ydbio.2018.07.004

Cited by 61 publications

(60 citation statements)

References 154 publications

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“…The embryonic neural crest cells can give rise to islet cell tissue. The vagal neural crest cells play an important role in differentiation of endoderm-derived organs such as the thymus, lungs, and pancreas [14]. Melanocytic differentiation and melanin pigment formation were observed in some pancreatic tumors such as solid pseudopapillary neoplasms (SPN) [15].…”

Section: Resultsmentioning

confidence: 99%

Melanoma of unknown primary in the pancreas: should it be considered primary?

Jin

Ran

et al. 2020

BMC Surg

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Background: Malignant melanoma is characterized as highly malignant due to its rapid growth and early metastasis. Metastatic melanoma from occult primary is rare. Melanoma of unknown primary in pancreas are even rear. But it is a biologically ill-defined and clinically understudied concept. Case presentation: In this report, a 43-year-old man was diagnosed with pancreatic carcinoma. Extended total pancreatectomy together with portal vein reconstruction and extensive lymphadenectomy were performed in our hospital. The patient was diagnosed with pancreatic malignant melanoma after pathological examination. He was still alive 20 months after the operation without any evidence of recurrence. Conclusion: The described case highlights the possibility of primary pancreatic malignant melanoma and the treatment strategies of this rare carcinoma.

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Section: Resultsmentioning

confidence: 99%

Melanoma of unknown primary in the pancreas: should it be considered primary?

Jin

Ran

et al. 2020

BMC Surg

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“…The vagal NC, which has been described as a transitional population between cranial and trunk NCCs, arises from somites 1 to 7, where both a dorsal and a ventral migration pathway would take place in temporal succession (Kuo & Erickson, ; Le Douarin & Teillet, ; Pomeranz, Rothman, & Gershon, ). It is worth noting that other classifications consider cardiac NC and enteric NC as part of the vagal NC population (Hutchins et al, ). In this review, we will consider the vagal NC as a hybrid population that has shared characteristics with cardiac and trunk NC.…”

Section: Neural Crest Derivativesmentioning

confidence: 99%

The role of teratogens in neural crest development

Cerrizuela

Vega-Lopez

Aybar

2020

Birth Defects Research

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The neural crest (NC), discovered by Wilhelm His 150 years ago, gives rise to a multipotent migratory embryonic cell population that generates a remarkably diverse and important array of cell types during the development of the vertebrate embryo. These cells originate in the neural plate border (NPB), which is the ectoderm between the neural plate and the epidermis. They give rise to the neurons and glia of the peripheral nervous system, melanocytes, chondrocytes, smooth muscle cells, odontoblasts and neuroendocrine cells, among others. Neurocristopathies are a class of congenital diseases resulting from the abnormal induction, specification, migration, differentiation or death of NC cells (NCCs) during embryonic development and have an important medical and societal impact. In general, congenital defects affect an appreciable percentage of newborns worldwide. Some of these defects are caused by teratogens, which are agents that negatively impact the formation of tissues and organs during development. In this review, we will discuss the teratogens linked to the development of many birth defects, with a strong focus on those that specifically affect the development of the NC, thereby producing neurocristopathies.Although increasing attention is being paid to the effect of teratogens on embryonic development in general, there is a strong need to critically evaluate the specific role of these agents in NC development. Therefore, increased understanding of the role of these factors in NC development will contribute to the planning of strategies aimed at the prevention and treatment of human neurocristopathies, whose etiology was previously not considered.

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“…Neural crest stem cells (NCSCs) are prototypical migratory cells of vertebrate embryos; they emigrate from the dorsal neural tube and, by following stereotyped migratory routes, colonize specific embryonic sites where they generate diverse derivatives including the enteric nervous system (ENS) [ 1 ]. Therefore, NCSCs are very important for the pathogenesis of intestinal neuronal dysplasia, colonic motility disorders, and functional gastrointestinal diseases [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Sox10 Is a Specific Biomarker for Neural Crest Stem Cells in Immunohistochemical Staining in Wistar Rats

Yang

Huang

et al. 2020

Disease Markers

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Objective. Neural crest stem cells (NCSCs) are prototypically migratory cells immigrating from the dorsal neural tube to specific embryonic sites where they generate a variety of cell types. A lot of biomarkers for NCSCs have been identified. However, which biomarkers are the most specific is still unclear. Methods. The rat embryos harvested in embryonic day 9 (E9), E9.5, E10, E10.5, E11, E12, E13, and E14 were paraffin-embedded and sectioned in transverse. NCSCs were spatiotemporally demonstrated by immunohistochemical staining with RET, p75NTR, Pax7, and Sox10. NCSCs were isolated, cultured, and stained with RET, p75NTR, Pax7, and Sox10. Results. In the paraffin sections of rat embryos, the immunohistochemical staining of RET, p75NTR, and Sox10 can all be used in demonstrating NCSCs. Sox10 was positive mainly in NCSCs while RET and p75NTR were positive not only in NCSCs but also in other tissue cells. In primary culture cells, Sox10 was mainly in the nucleus of NCSCs, RET was mainly in the membrane, and p75NTR was positive in cytoplasm and membrane. Conclusions. Sox10 is the specific marker for immunohistochemical staining of NCSCs in paraffin sections. In cultured cells, Sox10, p75NTR, and RET presented a similar staining effect.

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Migration and diversification of the vagal neural crest

Cited by 61 publications

References 154 publications

Melanoma of unknown primary in the pancreas: should it be considered primary?

Melanoma of unknown primary in the pancreas: should it be considered primary?

The role of teratogens in neural crest development

Sox10 Is a Specific Biomarker for Neural Crest Stem Cells in Immunohistochemical Staining in Wistar Rats

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