Migration and granulomatous reaction after periurethral injection of polytef (Teflon)

Absence of Brain Parenchymal Damage following Intravascular Injection of Polytetrafluoroethylene Paste

“…Most paediatric urologists acknowledge the success of the endoscopic approach to correct vesicoureteral reflux. However, some have been concerned by the use of PTFE as the implanted substance, because migration of PTFE particles after periurethral, periureteral, and intravenous injections has been reported in animals studies [11, 12]. Miyakita and Puri [13]recently performed a detailed experimental study in two animal species to determine whether PTFE particles migrate to the lungs and brain after subureteral injection of PTFE paste.…”

Endoscopic Correction of Vesicoureteric Reflux in Failed Reimplanted Ureters

“…This study clearly showed that subureteral polytetrafluoroethylene injection using minimal quantities of paste is not associated with distant particle migration. The experimental results with migration as reported by Malizia et al [15], and Aaronson and co-workers [16, 17, 18] have not been supported by the extensive worldwide clinical experience with the use of PTFE paste. No long-term morbidity has been reported to date with the use of PTFE paste to treat urinary incontinence or to correct reflux despite widespread application.…”

“…However, some have been concerned by the use of polytetrafluoroethylene paste as the implanted substance because distant migration of polytetrafluoroethylene particles after periurethral, periureteral and intravenous injection has been reported in animal studies [15, 16, 17, 18]. Miyakita and Puri [19] recently performed a detailed experimental study in two animal species to determine whether polytetrafluoroethylene particles migrate to the lungs and brain after the subureteral, intravenous or intra-arterial injection of polytetrafluoroethylene paste.…”

Implantable Microballoons: An Attractive Alternative in the Management of Intrinsic Sphincter Deficiency

“…The agent has been noted to have good tissue biocompatibility and a low complication rate at periurethral implantation. With longer follow-up, however, local inflammation induced by the migration of the relatively small silicone particles (100–300 µm) has been observed [16, 31]. …”