Migration behavior and enantioseparation of hydrobenzoin and structurally related compounds in capillary zone electrophoresis with a dual cyclodextrin system consisting of heptakis-(2,3-dihydroxy-6-O-sulfo)-β-cyclodextrin and β-cyclodextrin

Lin, Chin‐Feng; Lin, Shinn-Kuang; Cheng, Hsu-Tun; Fang, I-Ju; Kuo, Chia‐Ming; Liu, Yu-Chih

doi:10.1002/elps.200500294

Cited by 9 publications

(3 citation statements)

References 36 publications

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“…However, in cases where the EMO reversal was discussed in the dual‐selector chiral separations, the authors made mostly qualitative considerations regarding each selector's recognition pattern and the effect on the analytes’ mobility . Similarly, the weighted mobility difference Eq.…”

Section: Dual Selector Modelsmentioning

confidence: 99%

Twenty years of development of dual and multi‐selector models in capillary electrophoresis: A review

2014

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It has been 20 years since Lurie et al. first published their model of electromigration of an analyte under simultaneous interaction with two cyclodextrins as chiral selectors. Since then, the theory of (enantio)separation in dual and complex mixtures of (chiral) selectors is well understood. In spite of this, a trial-and-error approach still prevails in analytical practice. Such a situation is likely caused by the fact that the entire theory is spread over numerous papers and the relations between various models are not always clear. The present review condenses the theory for the first time. Available mathematical models and feasible practical approaches are summarized and their advantages and limitations discussed.

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Section: Dual Selector Modelsmentioning

confidence: 99%

Twenty years of development of dual and multi‐selector models in capillary electrophoresis: A review

2014

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“…Among articles dealing with the determination of interaction constants of various analytes with charged CDs, methanol seems to be the most popular EOF marker . The other often used neutral markers are: mesityl oxide (MO) , DMSO , thiourea (TU) , nitromethane (NM) , ethanol , and acetone .…”

Section: Introductionmentioning

confidence: 99%

Determination of effective mobilities of EOF markers in BGE containing sulfated β‐cyclodextrin by a two‐detector method

et al. 2013

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A neutral marker of the EOF can gain a nonzero effective mobility because of its possible interaction with a charged complexing agent, such as a chiral selector in CE. We determined effective mobilities of four compounds often used as EOF markers (dimethyl sulfoxide, mesityl oxide, nitromethane, and thiourea) in the BGE-containing sulfated β-CD (60 g/L). All the compounds studied were measurably mobilized by their interaction with the selector. The highest effective mobility (-3.0·10(-9) m(2) s(-1) V(-1)) was observed for thiourea and the lowest (-1.5·10(-9) m(2) s(-1) V(-1)) for dimethyl sulfoxide and nitromethane. The mobilities were determined by a new two-detector pressure mobilization method (2d method), which we propose, and the results were confirmed by standard CE measurements. In the 2d method, one marker zone is situated in the BGE containing the charged selector, while the second marker zone is surrounded with a selector-free BGE, which prevents its complexation. The initial distance between the two marker zones equals the capillary length from the inlet to the first detector. After a brief voltage application, the final distance between the marker zones is determined based on known capillary length from the first to the second detector. The difference between these two distances determines the effective mobility.

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“…It is well established that the extent of the variation of the mobility of an analyte as a function of the concentration of a chiral selector, which depends actually on both the binding constant and limiting electrophoretic mobility, may reflect the binding strength of an analyte with the chiral selector [42]. As the extents of the variations of the mobility of the three hydroxyflavanones studied are about the same, it is expected that the interactions of these three hydroxyflavanones with S-␤-CD may vary only to a small extent and that the migration order of hydroxyflavanones depends primarily on the limiting electrophoretic mobility, which can be determined from the mobility of hydroxyflavanones in the dissociated form at a pH above pK a plus two pH units.…”

Section: S-β-cd As a Chiral Selectormentioning

confidence: 99%

Chiral separation of hydroxyflavanones in cyclodextrin-modified capillary zone electrophoresis using sulfated cyclodextrins as chiral selectors

Lin

Fang

Kuo

et al. 2008

Journal of Chromatography A

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Migration behavior and enantioseparation of hydrobenzoin and structurally related compounds in capillary zone electrophoresis with a dual cyclodextrin system consisting of heptakis-(2,3-dihydroxy-6-O-sulfo)-β-cyclodextrin and β-cyclodextrin

Cited by 9 publications

References 36 publications

Twenty years of development of dual and multi‐selector models in capillary electrophoresis: A review

Twenty years of development of dual and multi‐selector models in capillary electrophoresis: A review

Determination of effective mobilities of EOF markers in BGE containing sulfated β‐cyclodextrin by a two‐detector method

Chiral separation of hydroxyflavanones in cyclodextrin-modified capillary zone electrophoresis using sulfated cyclodextrins as chiral selectors

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