Migration in Vitro by Blood and Exudate Neutrophils Assessed Serially During an Inflammatory Response

Wd, Biggar; Barker, C; Hamilton, G.; Crawford, Linda; Bohn, Desmond; Kent, Geraldine

doi:10.3109/08820138609054914

Cited by 1 publication

(2 citation statements)

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“…In animal models, exudate neutrophils demonstrate reduced chemotactic response [166]. In humans, neutrophils isolated from skin windows have diminished chemotactic ability when compared with circulating neutrophils [159].…”

Section: Neutrophil Cell Surface Expression In the Exudate Environmentmentioning

confidence: 99%

“…Exudate neutrophils exhibit a reduced number of chemoattractant receptors, along with reduced chemotaxis. In animal models, exudate neutrophils demonstrate reduced chemotactic response [ 166 ]. In humans, neutrophils isolated from skin windows have diminished chemotactic ability when compared with circulating neutrophils [ 159 ].…”

Section: Neutrophil Cell Surface Expression In the Exudate Environmentmentioning

confidence: 99%

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2003

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291 FADD = Fas-associated death domain; FasL = Fas ligand; FMLP = f-Met-Leu-Phe; G-CSF = granulocyte colony-stimulating factor; GM-CSF = granulocyte/macrophage colony-stimulating factor; GRO = growth-related oncogene; H 2 O 2 = hydrogen peroxide; ICAM = intercellular adhesion molecule; IL = interleukin; MIP = macrophage inflammatory protein; NADPH = reduced nicotinamide adenine dinucleotide phosphate; NF-κB = nuclear factor-κB; O 2 -• = superoxide anion; PECAM = platelet-endothelial cell adhesion molecule; TNF = tumor necrosis factor.Available online http://ccforum.com/content/7/4/291Tissue inflammation, manifesting clinically as rubor, calor, tumor, and dolor, has been a focus of investigation since the beginning of medical science. Inflammation may be defined as a condition or state that tissues enter as a response to injury or insult. The neutrophil is the most important and the most extensively studied cell involved in the inflammatory response. As the principal circulating phagocyte, the neutrophil is the first and most abundant leukocyte to be delivered to a site of infection or inflammation, and is thus an integral component of the innate immune system. In addition to its role in host defense, the neutrophil is implicated in the pathogenesis of tissue injury and of persistent inflammatory diseases. The paradoxic roles of the neutrophil in host defense and host injury have fueled intense scientific inquiry into the processes of neutrophil delivery to a site of inflammation, neutrophil function within the inflammatory environment, and neutrophil clearance from that milieu.The aim of the present review is to highlight the importance of neutrophil cell membrane expression in the participation and regulation of neutrophil delivery, function, and clearance from its environment. AbstractAs the principal cellular component of the inflammatory host defense and contributor to host injury after severe physiologic insult, the neutrophil is inherently coupled to patient outcome in both health and disease. Extensive research has focused on the mechanisms that regulate neutrophil delivery, function, and clearance from the inflammatory microenvironment. The neutrophil cell membrane mediates the interaction of the neutrophil with the extracellular environment; it expresses a complex array of adhesion molecules and receptors for various ligands, including mediators, cytokines, immunoglobulins, and membrane molecules on other cells. This article presents a review and analysis of the evidence that the neutrophil membrane plays a central role in regulating neutrophil delivery (production, rolling, adhesion, diapedesis, and chemotaxis), function (priming and activation, microbicidal activity, and neutrophil-mediated host injury), and clearance (apoptosis and necrosis). In addition, we review how change in neutrophil membrane expression is synonymous with change in neutrophil function in vivo. Employing a complementary analysis of the neutrophil as a complex system, neutrophil membrane expression may be regarded as a measure o...

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Section: Neutrophil Cell Surface Expression In the Exudate Environmentmentioning

confidence: 99%

Section: Neutrophil Cell Surface Expression In the Exudate Environmentmentioning

confidence: 99%