Migration of an outer retinal element in a healthy child followed by longitudinal multimodal imaging

Torm, Marie Elise Wistrup; Belmouhand, Mohamed; Munch, Inger Christine; Larsen, Michael; Rothenbuehler, S. P.

doi:10.1016/j.ajoc.2020.100637

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…Small hyperreflective dots have recently been documented inside PHOMS on OCT and proposed to represent microcalcifications and possible “ODD precursors” (46). This is highly speculative, however, as such dots are nonspecific, can be found throughout the retina, and are seen in PHOMS of all etiologies, not just ODD-associated PHOMS (54–57). Furthermore, they seem to resolve when the PHOMS does (Fig.…”

Section: What Is a Phoms?mentioning

confidence: 99%

Peripapillary Hyper-reflective Ovoid Mass-like Structure (PHOMS): An Optical Coherence Tomography Marker of Axoplasmic Stasis in the Optic Nerve Head

Fraser

Sibony

Petzold

et al. 2021

Journal of Neuro-Ophthalmology

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for the ODDS ConsortiumBackground: With the development and widespread adoption of spectral-domain optical coherence tomography (OCT), peripapillary hyper-reflective ovoid mass-like structures (PHOMS) have become a frequent OCT finding in neuro-ophthalmic practice. Although originally assumed to represent a form of buried optic disc drusen (ODD), PHOMS differ from ODD in many important ways. The histopathological underpinnings of PHOMS are now becoming more clearly understood. Evidence acquisition: Review of literature. Results: PHOMS can be broadly classified as disk edemaassociated PHOMS, ODD-associated PHOMS, or anomalous disk-associated PHOMS. PHOMS are seen in many conditions, including papilledema, nonarteritic anterior ischemic optic neuropathy, central retinal vein occlusion, acute demyelinating optic neuritis, ODD, and tilted disks (myopic obliquely inserted disks) and in many cases resolve along with the underlying condition. The histopathological study of these diverse entities reveals the common feature of a bulge of optic nerve fibers herniating centrifugally over Bruch membrane opening into the peripapillary space, correlating exactly with the location, shape, and space-occupying nature of PHOMS on OCT. Because of the radial symmetry of these herniating optic nerve fibers, PHOMS are best thought of as a complete or partial torus (i.e., donut) in 3 dimensions. Conclusions: PHOMS are a common but nonspecific OCT marker of axoplasmic stasis in the optic nerve head. They are not themselves ODD or ODD precursors, although they can be seen in association with ODD and a wide spectrum of other conditions. They do not exclude papilledema and often accompany it. The circumferential extent and characteristic 3D toroidal nature of a PHOMS are best appreciated by scrolling through consecutive OCT images.

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Section: What Is a Phoms?mentioning

confidence: 99%

Peripapillary Hyper-reflective Ovoid Mass-like Structure (PHOMS): An Optical Coherence Tomography Marker of Axoplasmic Stasis in the Optic Nerve Head

Fraser

Sibony

Petzold

et al. 2021

Journal of Neuro-Ophthalmology

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“…This model can create fused representations by combining features across modalities [12]. Torm M discussed various scenarios that may arise in multimodal biometric systems, reasonable levels of fusion, and integration strategies that can be employed to integrate information [13]. Raphael K analyzed the multimodal interactions of people speaking and writing to simulate dynamic map systems.…”

Section: Introductionmentioning

confidence: 99%

Evaluation on Multimodal College Music Teaching Mode Based on Interactive Sentiment

2024

IJEIS

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The teaching mode of music is a relatively stable and operational curriculum structure and system based on specific teaching concepts and specific teaching purposes. In the process of comprehensively promoting quality education, students' moral cultivation, aesthetic sentiment, and innovation consciousness have been given comprehensive attention. Music, as a main content of humanistic literacy, is widely used as an open elective course in many schools. Judging from the current music teaching, on the one hand, there are problems such as single teaching mode and loose structure; on the other hand, there are problems such as poor basic music skills of teaching objects, unclear teaching purpose, and poor teaching quality. To this end, it is necessary to change the current teaching status and study new teaching modes, so as to further stimulate students' interest in music learning and give full play to the role of music teaching in aesthetic education. Based on the multi-modality of interactive sentiment analysis, this paper studied the music teaching mode in colleges and universities. Through the research, students' interest in music learning has increased by 6.83%.

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“…The presence of hyperreflective foci was first described in diabetic macular oedema as a morphologic sign of lipid extravasation (Bolz et al, 2009). However, in the past decade, hyperreflective foci have been characterized in a considerable amount of different retinal disorders and with the use of various of morphological entities such as migrating retinal pigment epithelium cells, macrophages/microglia in age‐related macular degeneration (AMD) (Curcio et al, 2017; Framme et al, 2010; Pang et al, 2015) and degenerated photoreceptor cells (Torm et al, 2020; Uji et al, 2012). Furthermore, a cell‐sized migrating intraretinal hyperreflective element has been observed incidentally in a healthy child (Torm et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Automated detection of hyperreflective foci in the outer nuclear layer of the retina

Schmidt

Christensen

Dahl

et al. 2022

Acta Ophthalmologica

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Hyperreflective foci are poorly understood transient elements seen on optical coherence tomography (OCT) of the retina in both healthy and diseased eyes. Systematic studies may benefit from the development of automated tools that can map and track such foci. The outer nuclear layer (ONL) of the retina is an attractive layer in which to study hyperreflective foci as it has no fixed hyperreflective elements in healthy eyes. In this study, we intended to evaluate whether automated image analysis can identify, quantify and visualize hyperreflective foci in the ONL of the retina.Methods: This longitudinal exploratory study investigated 14 eyes of seven patients including six patients with optic neuropathy and one with mild non-proliferative diabetic retinopathy. In total, 2596 OCT B-scan were obtained. An image analysis blob detector algorithm was used to detect candidate foci, and a convolutional neural network (CNN) trained on a manually labelled subset of data was then used to select those candidate foci in the ONL that fitted the characteristics of the reference foci best. Results:In the manually labelled data set, the blob detector found 2548 candidate foci, correctly detecting 350 (89%) out of 391 manually labelled reference foci. The accuracy of CNN classifier was assessed by manually splitting the 2548 candidate foci into a training and validation set. On the validation set, the classifier obtained an accuracy of 96.3%, a sensitivity of 88.4% and a specificity of 97.5% (AUC 0.989). Conclusion:This study demonstrated that automated image analysis and machine learning methods can be used to successfully identify, quantify and visualize hyperreflective foci in the ONL of the retina on OCT scans.

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Migration of an outer retinal element in a healthy child followed by longitudinal multimodal imaging

Cited by 4 publications

References 12 publications

Peripapillary Hyper-reflective Ovoid Mass-like Structure (PHOMS): An Optical Coherence Tomography Marker of Axoplasmic Stasis in the Optic Nerve Head

Peripapillary Hyper-reflective Ovoid Mass-like Structure (PHOMS): An Optical Coherence Tomography Marker of Axoplasmic Stasis in the Optic Nerve Head

Evaluation on Multimodal College Music Teaching Mode Based on Interactive Sentiment

Automated detection of hyperreflective foci in the outer nuclear layer of the retina

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