Migration of Eosinophils and CCR2-/CD68-Double Positive Cells Into the Duodenal Mucosa of Patients With Postinfectious Functional Dyspepsia

Futagami, Seiji; Shindo, Tetsuya; Kawagoe, Tetsuro; Horie, Akane; Shimpuku, Mayumi; Gudis, Katya; Iwakiri, Katsuhiko; Itoh, Takashi; Sakamoto, Choitsu

doi:10.1038/ajg.2010.151

Cited by 118 publications

(105 citation statements)

References 34 publications

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“…A recent study found the degree of histological duodenitis in bacterial postinfectious dyspepsia to be signifi cantly higher than that found in healthy volunteers and correlate with epigastric burning; however, no correlation was found with gastric emptying values ( 34 ). Th ese authors also observed that CCR2-positive macrophage and eosinophil counts were signifi cantly increased.…”

Section: Pathophysiology Of Postinfectious Dyspepsiasupporting

confidence: 60%

Postinfectious Chronic Gut Dysfunction: From Bench to Bedside

Collins¹,

Chang²,

Mearin³

2012

Am J Gastroenterol Suppl

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Section: Pathophysiology Of Postinfectious Dyspepsiasupporting

confidence: 60%

Postinfectious Chronic Gut Dysfunction: From Bench to Bedside

Collins¹,

Chang²,

Mearin³

2012

Am J Gastroenterol Suppl

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Section: Mechanisms/pathophysiologymentioning

confidence: 99%

“…The most widely used generic measure, the Short Form 36-Item Health Survey (SF-36) 222 , assesses eight dimensions of health: physical functioning, social functioning, Nature Reviews | Disease Primers Fatty foods , milk and dairy Alcohol , coffee Red meat Carbonated drinks Vegetables Spicy foods Carbohydrates and wheat (37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53) Citrus (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46) Figure 5 | Foods and food groups frequently associated with symptom induction or exacerbation in functional dyspepsia. Offending foods reported by patients with functional dyspepsia include fatty food (for example, fried food [179][180][181]187,191 ), alcohol 179,180 , dairy products 179,181 , coffee [179]…”

Section: Quality Of Lifementioning

confidence: 99%

“…pylori-related dyspepsia is considered a separate entity. However, other prior gastrointestinal infections have been described as triggers of functional dyspepsia, by impairing gastric accommodation (a vagally mediated reflex that occurs postprandially and results in a reduction of smooth muscle tone; the stomach relaxes and provides a reservoir for the meal), possibly via immune mechanisms [51][52][53] .Communication between the central nervous system and the enteric nervous system has been recognized for over a century, but the fact that brain-gut communications are bi-directional has only been appreciated more recently 54,55 . Innervation of the gastrointestinal tract regulates secretions, sphincter control, motility, blood flow and enteroendocrine function, and the enteric nervous system also communicates with the intestinal barrier via neuroendocrine and mucosal immune cells 54,56 .…”

mentioning

confidence: 99%

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Functional dyspepsia

Enck¹,

Azpiroz

Boeckxstaens

et al. 2017

Nat Rev Dis Primers

260

247

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| Functional dyspepsia is one of the most prevalent functional gastrointestinal disorders. Functional dyspepsia comprises three subtypes with presumed different pathophysiology and aetiology: postprandial distress syndrome (PDS), epigastric pain syndrome (EPS) and a subtype with overlapping PDS and EPS features. Functional dyspepsia symptoms can be caused by disturbed gastric motility (for example, inadequate fundic accommodation or delayed gastric emptying), gastric sensation (for example, sensations associated with hypersensitivity to gas and bloating) or gastric and duodenal inflammation. A genetic predisposition is probable but less evident than in other functional gastrointestinal disorders, such as irritable bowel syndrome (IBS). Psychiatric comorbidity and psychopathological state and trait characteristics could also play a part, although they are not specific to functional dyspepsia and are less pronounced than in IBS. Possible differential diagnoses include Helicobacter pylori infection and peptic ulceration. Pharmacological therapy is mostly based on the subtype of functional dyspepsia, such as prokinetic and fundus-relaxing drugs for PDS and acid-suppressive drugs for EPS, whereas centrally active neuromodulators and herbal drugs play a minor part. Psychotherapy is effective only in a small subset of patients, whereas quality of life can be severely affected in nearly all patients. Future therapies might include novel compounds that attempt to treat the underlying gastric and duodenal inflammation. NATURE REVIEWS | DISEASE PRIMERS VOLUME 3 | ARTICLE NUMBER 17081 | 1 PRIMER © 2 0 1 7 M a c m i l l a n P u b l i s h e r s L i m i t e d , p a r t o f S p r i n g e r N a t u r e . A l l r i g h t s r e s e r v e d .standard therapy for gastro -oesophageal reflux disease. Paediatric dyspeptic symptoms are being addressed in a separate classification effort 10 . This Primer covers functional dyspepsia in adults only, although we sporadically refer to paediatric functional dyspepsia when similarities exist. EpidemiologyThe population prevalence of functional dyspepsia is quite variable across the globe, with overall high numbers (10-40%) in Western countries and low numbers (5-30%) in Asia, independent of the respective functional dyspepsia definitions 11 . A large-scale health and nutrition survey from France 12 (which involved >35,000 people) identified that 15% of individuals had suspected functional dyspepsia, 28% had irritable bowel syndrome (IBS) and 6% had both. The population of patients who are affected by both IBS and functional dyspepsia has been reported to range between 10% and 27% in previous studies 13 and to approach 30% in popu lation samples; it could be even higher in specific populations 14,15 . This observation has given rise to the term 'overlap syndrome' (REF. 13), which calls into question the sensitivity and specificity of the Rome criteria, at least for IBS and functional dyspepsia. This argument is also supported by the observation that patients with functional dyspepsia m...

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“…Comment: In some cases of infectious gastroenteritis accompanied by fever, diarrhea, nausea, vomiting, and positive stool culture, studies have shown that FD symptoms persist long after the elimination of the causative pathogens [32,33]. Postinfectious FD is associated with early satiety, weight loss, and nausea [34].…”

Section: Postinfectious Fdmentioning

confidence: 99%

Evidence-based clinical practice guidelines for functional dyspepsia

et al. 2015

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General interest in functional gastrointestinal disorders is increasing among Japanese doctors as well as patients. This increase can be attributed to a number of factors, including recent increased interest in quality of life and advances in our understanding of the pathophysiology of gastrointestinal disease. Japan recently became the world's first country to list ''functional dyspepsia'' as a disease name for national insurance billing purposes. However, recognition and understanding of functional dyspepsia (FD) remain poor, and no standard treatment strategy has yet been established. Accordingly, the Japanese Society of Gastroenterology (JSGE) developed an evidence-based clinical practice guideline for FD, consisting of five sections: concept, definition, and epidemiology; pathophysiology; diagnosis; treatment; and prognosis and complications. This article summarizes the Japanese guideline, with particular focus on the treatment section. Once a patient is diagnosed with FD, the doctor should carefully explain the pathophysiology and benign nature of this condition, establish a good doctor-patient relationship, and then provide advice for daily living (diet and lifestyle modifications, explanations, and reassurance). The proposed pharmacological treatment is divided into two steps: initial treatment including an acid inhibitory drug (H2RA or PPI) or prokinetics, (strong recommendation); second-line treatment including anxiolytics, antidepressants, and Japanese traditional medicine (weak recommendation). H. pylori eradication, strongly recommended with a high evidence level, is positioned separately from other treatment flows. Conditions that do not respond to these treatment regimens are regarded as refractory FD. Patients will be further examined for other organic disorders or will be referred to specialists using other approaches such as psychosomatic treatment.

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Migration of Eosinophils and CCR2-/CD68-Double Positive Cells Into the Duodenal Mucosa of Patients With Postinfectious Functional Dyspepsia

Abstract: Migration of inflammatory cells, in particular, duodenal CCR2-positive macrophages, may have an important function in the pathophysiology of postinfectious FD patients.

Cited by 118 publications

References 34 publications

Postinfectious Chronic Gut Dysfunction: From Bench to Bedside

Postinfectious Chronic Gut Dysfunction: From Bench to Bedside

Functional dyspepsia

Evidence-based clinical practice guidelines for functional dyspepsia

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