Migration of human and mouse primordial germ cells and colonization of the developing ovary: An ultrastructural and cytochemical study

Pereda, Jaime; Zorn, Telma Maria Tenório; Soto-Suazo, Maurício

doi:10.1002/jemt.20298

Cited by 43 publications

(37 citation statements)

References 58 publications

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“…In the human embryo, migratory PGCs appear to be surrounded by extracellular matrix components in which mesenchymal cells are immersed. PGCs seem to interact with the mesenchymal cells through different type of junctions, such as desmosomes, gap junctions, and focal contacts [ 77,87 ] . Glucosaminoglycans have been histochemically detected in the extracellular matrix surrounding migratory human PGCs ( [ 87 ] and references here in).…”

Section: Migration Of Human Pgcsmentioning

confidence: 99%

Origin, Migration, and Proliferation of Human Primordial Germ Cells

Felici

2012

Oogenesis

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The fi rst histological observations about the origin of the precursors of gametes termed primordial germ cells (PGCs) in extragonadal regions and their subsequent migration into the developing gonads in human embryos date back to the early twentieth century. Fuss (Anat Am 39:407-409, 1911, Anat EntwMech 81:1-23, 1912 and Felix (Die Entwicklung der Harn-und Geschlechtsorgane. In: Keibel-Mall Handbuch der 1qEntwick-lungageschichte des Menshen, vol 2. Leipzig, Hirzel, pp 732-955, 1911) were apparently the fi rst ones to describe the extragonadal location of PGCs in human embryos. In the youngest, 2.5 mm long, embryo examined (23-26 days postfertilization), These authors described PGCs in the endoderm of the yolk sac wall as cells identi fi able by their large size and spherical shape. Subsequently, Politzer (Z Anat Entw Gesch 87: 766-80, 1928, Z Anat Entw Gesch 93:386-428, 1930, Z Anat EntwGesch 100:331-336, 1933 and Witschi (Contr Embryol Carnegie Inst 209:67-80, 1948) studied the distribution of PGCs in a considerable number of embryos from presomite stages (0.3-0.8 mm, about 3 weeks) to 8.5 mm (5 weeks). Both authors described the migration of PGCs from the yolk sac to the developing gonads. Following a hot debate, it is now generally accepted that after their arrival into the gonadal anlage, PGCs give rise to the oogonia/oocytes and gonocytes (or prespermatogonia) in the embryonic ovary and testis, respectively. These germ cells enter a complex series of events that in the

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Section: Migration Of Human Pgcsmentioning

confidence: 99%

Origin, Migration, and Proliferation of Human Primordial Germ Cells

Felici

2012

Oogenesis

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“…Tentatively, we propose that this has been caused by oogonial malsegregation at around 5-week gestational age, i.e. when the migrating germ cells have reached their final destination in the mesenchyme of the urogenital ridge (Bendsen et al 2006, Pereda et al 2006. Figure 1 Increased proportion of T21 oocytes in the ageing ovary.…”

Section: Aneuploidy Mosaicism Is Common In Human Embryosmentioning

confidence: 99%

On the origin of the maternal age effect in trisomy 21 Down syndrome: the Oocyte Mosaicism Selection model

Hultén

Patel²,

Jonasson³

et al. 2010

Reproduction

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We have recently documented that trisomy 21 mosaicism is common in human foetal ovaries. On the basis of this observation we propose that the maternal age effect in Down syndrome (DS) is caused by the differential behaviour of trisomy 21 in relation to disomy 21 oocytes during development from foetal life until ovulation in adulthood. In particular, we suggest that trisomy 21 oocytes, lagging behind those that are disomic, may escape the timed pruning of the seven million in foetal life to the 300-400 finally selected for ovulation. The net effect of this preferential elimination will be an accumulation of trisomy 21 oocytes in the ovarian reserve of older women. We here highlight the implications of this Oocyte Mosaicism Selection (OMS) model with respect to the prevalent view that the maternal age effect is complex, dependent on many different biological and environmental factors. We examine conclusions drawn from recent largescale studies in families, tracing DNA markers along the length of chromosome 21q between parents and DS children, in comparison to the OMS model. We conclude that these family linkage data are equally compatible with the maternal age effect originating from the accumulation of trisomy 21 oocytes with advancing maternal age. One relatively straightforward way to get to grips with what is actually going on in this regard would be to compare incidence of trisomy 21 oocytes (and their pairing configurations) in foetal ovaries with that in oocytes at the meiosis I stage from adult women.

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“…On the ventromedial side of the bovine mesonephros, the first indifferent gonad primordium called genital ridge or genital crest can be discerned at day 28-32 of gestation [Fischel, 1929;Clara, 1965;Noden and de Lahunta, 1985;Rüsse and Sinowatz, 1998]. The genital ridge consisting of coelomic epithelium and an aggregation of underlying mesenchymal cells starts to proliferate with the arrival of the PGCs [Byskov, 1986;Pereda et al, 2006]. During this indifferent stage of gonadal development the PGCs migrate from the yolk sac via hindgut wall and dorsal mesentery into the genital ridge [McGee et al, 1998;Rüsse and Sinowatz, 1998].…”

mentioning

confidence: 99%

The Role of Ovarian Surface Epithelium in Folliculogenesis during Fetal Development of the Bovine Ovary: A Histological and Immunohistochemical Study

Kenngott

Vermehren

Ebach

et al. 2013

Sex Dev

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Although many aspects of ovarian differentiation have been established, comparatively little is known about prenatal follicle formation and differentiation of bovine ovaries. The objective of this investigation was to study the role of the surface epithelium during the development of germ cell nests, germ cell cords and follicle formation in the fetal bovine ovary. Associated important proliferation and apoptotic features were further investigated. Additionally, the expression pattern of the S100 protein was detected. A strong increase of mitotic figures was detected in the surface epithelium, germ cell nests and germ cell cords of ovaries with a crown-rump length (CRL) of 13.0-58.0 cm. Oocytes were positively stained with S100 in bovine ovaries from fetuses with a CRL of 21.0 cm. The staining intensity enhanced parallel to increasing oocyte and follicle sizes during the ovary development. In later stages, a strong staining for S100 was observed in healthy oocytes in contradistinction to atretic oocytes where no expression of the S100 protein could be found. In conclusion, increasing mitosis index of surface epithelium cells, as well as oogonia directly beneath the surface epithelium, in combination with open surface connection during stages from a CRL of 11.0-94.0 cm of bovine fetal ovaries could play an important role in the period of time of ongoing folliculogenesis and derivation of granulosa cells. Additionally, S100-positive oocytes in primordial and later follicle stages joined by a high rate of Ki67-positive index in surrounding granulosa cells indicate that in the oocytes the S100 protein can perhaps be a useful marker for intact oocytes in bovine ovaries.

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Migration of human and mouse primordial germ cells and colonization of the developing ovary: An ultrastructural and cytochemical study

Cited by 43 publications

References 58 publications

Origin, Migration, and Proliferation of Human Primordial Germ Cells

Origin, Migration, and Proliferation of Human Primordial Germ Cells

On the origin of the maternal age effect in trisomy 21 Down syndrome: the Oocyte Mosaicism Selection model

The Role of Ovarian Surface Epithelium in Folliculogenesis during Fetal Development of the Bovine Ovary: A Histological and Immunohistochemical Study

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