Migration pattern of Toxocara canis larvae in experimentally infected male and female Rattus norvegicus

Santos, Sérgio Vieira dos; Santos, Felipe Henrique Yazawa; Lescano, Susana Angélica Zevallos; Santos, Daniel Maurício dos; Tiago, Érico da Silva; Fonseca, Gabriela Rodrigues e; Ribeiro, Mauro C. C.; Chieffi, Pedro Paulo

doi:10.1590/0037-8682-0076-2017

Cited by 10 publications

(13 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the total number of larvae recovered in these organs was higher in females than in males, demonstrating that females are more susceptible than males to T. canis infection. [43]. These results are similar to those reported by our research group, where we observed that the number of larvae in the liver and lung has a dimorphic distribution, as females have a higher number of larvae in the liver than males; although these differences in the parasitic loads at the pulmonary level shows statistically significant differences, where males have a greater number of larvae than females.…”

Section: Discussionsupporting

confidence: 92%

Immune Sexual Dimorphism During Acute Infection by Toxocara canis: A Novel Approach for an Old Infection

Río-Araiza¹,

Alcalá-Canto²,

Garay-Canales³

et al. 2022

Preprint

View full text Add to dashboard Cite

Toxocara canis is a helminth parasite with importance in public and veterinary health. Although different studies have evaluated the immune response, to date there are no studies where it is analyzed from the point of view of sexual dimorphism. At 7 days of infection, female rats had a higher number of larvae in the liver, while male rats had them in the lungs. The percentages of immune cells were evaluated, and in most cases, no significant differences were observed. Regarding the cytokines production, infection can generate a decrease in Th1 such as IL-1β in both sexes and IL-6 only in females. In the case of Th2, IL-4 increases only in infected males and IL-5 increases in males and decreases in females due to the effect of infection. IL-10 also decreases in both sexes as a consequence of the infection and TGF-β only in females. Finally, the infection generates the production of antibody against the parasite, however, their quantity is lower in females. Thus, this study demonstrates that Toxocara canis infection is dimorphic and affects females more than males. This is due to a polarization of the inadequate immune response, which is reflected as a higher parasite load in this sex.

show abstract

Section: Discussionsupporting

confidence: 92%

Immune Sexual Dimorphism During Acute Infection by Toxocara canis: A Novel Approach for an Old Infection

Río-Araiza¹,

Alcalá-Canto²,

Garay-Canales³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Female rats showed a greater number of larvae in the liver than males. 117 Resende et al 82 studied the immunopathology of T. canis infections in mice and found similar larval migration patterns, with innate induction of TH17/TH2 responses during early infection. The migration patterns of T. canis larvae in the gerbil Meriones unguiculatus were similar to the patterns already observed in mice and rats; however, in reinfected animals, more larvae were apparently retained within hepatic granulomas, without evident signs of destruction.…”

Section: Experimental Studies In Nonhuman Paratenic Hostsmentioning

confidence: 93%

Human Toxocariasis: 2010 to 2020 Contributions from Brazilian Researchers

Chieffi¹,

Lescano²,

Fonseca³

et al. 2021

RRTM

Self Cite

View full text Add to dashboard Cite

show abstract

“…The beaker was placed in an incubator at 28°C and manually agitated twice daily to ensure the oxygenation of eggs to promote larvae development up to the third stage. After 20 days (the length of time required for thirdstage larval formation), the embryonated eggs were washed three times in saline solution to remove the formalin solution and prepared for infection in the rats (Santos, et al, 2017). Infective P. equorum eggs were collected and kept at 4°C until use.…”

Section: Collection Of Wormsmentioning

confidence: 99%

“…The second division (P. equorum infection division, 18 rats) was allocated into three groups. Group 1: Vehicle, 6 rats received a single oral dose of 1000 P. equorum eggs (Santos, et al, 2017) then received distilled water for 10 days. Group 2: ZnO NPs (30mg/kg), 6 rats received a single oral dose of 1000 P. equorum eggs and were then administered orally 1/ 20 LD 50 of ZnO NPs for 10 consecutive days.…”

Section: Experimental Designmentioning

confidence: 99%

Anthelmintic and hepatoprotective activities of the biocompatible Zinc Oxide Nanoparticles against Parascaris equorum infection in rats

Ali

Mohamed

Fahmy

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Nanoparticles have many properties, depending on their size, shape, and morphology, allowing them to interact with microorganisms, plants, and animals. Objectives: Investigatation of the therapeutic effects biocompatible zinc oxide nanoparticles (ZnO NPs) on P. equorum infection in rats. Methods: Thirty-six rats were divided into two divisions are: the first division is noninfected groups were allocated into three groups. Group 1: Control, Group 2: ZnO NPs (30mg/kg) and group 3: ZnO NPs (60mg/kg). The second division is infected groups were allocated into three groups. Group 1: vehicle, group 2: ZnO NPs (30mg/kg) and group 3: ZnO NPs (60mg/kg). Findings: Biocompatible ZnO NPs caused a significant decrease in liver functions, LDL, cholesterol, triglycerides, MDA and NO. While it caused a significant increase in HB, HDL, BCHE, GSH, CAT, and GST in infected treated rats. The histological inflammation and fibroplasia scores showed a significant enhancement during the treatment with ZnO NPs (30, 60mg/kg) compared to the infected untreated animals that scored the highest pathological destruction score. Immunohistochemical markers of NF-κB showed a significant decrease during the treatment with ZnO NPs (30, 60mg/kg) compared to the infected untreated animals. Main conclusions: Biocompatible Zinc Oxide Nanoparticle is a promising treatment modality against parasitic infection through its powerful anthelmintic, antioxidant, healing promotion, and anti-inflammation effects.

show abstract

Migration pattern of Toxocara canis larvae in experimentally infected male and female Rattus norvegicus

Cited by 10 publications

References 14 publications

Immune Sexual Dimorphism During Acute Infection by Toxocara canis: A Novel Approach for an Old Infection

Immune Sexual Dimorphism During Acute Infection by Toxocara canis: A Novel Approach for an Old Infection

Human Toxocariasis: 2010 to 2020 Contributions from Brazilian Researchers

Anthelmintic and hepatoprotective activities of the biocompatible Zinc Oxide Nanoparticles against Parascaris equorum infection in rats

Contact Info

Product

Resources

About