MIKC* MADS-Box Proteins: Conserved Regulators of the Gametophytic Generation of Land Plants

Zobell, Oliver; Faigl, Wolfram; Saedler, Heinz; Münster, Thomas

doi:10.1093/molbev/msq005

Cited by 72 publications

(84 citation statements)

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“…In the moss Physcomitrella patens, MIKC C -type genes function in the gametophyte as well as in specific tissues of the sporophyte, whereas MIKC*-type genes are specifically expressed in the gametophyte (Singer et al, 2007;Kwantes et al, 2012). This gametophytic expression appears to be highly conserved across land plant evolution and might reflect an ancestral, conserved role of MIKC*-type genes in gametophyte development (Verelst et al, 2007a;Zobell et al, 2010;Kwantes et al, 2012). The enigmatic origin and success of seed plants and, more recently, of flowering plants (angiosperms), is one of the biggest evolutionary mysteries.…”

Section: Transition To Floweringmentioning

confidence: 99%

Developmental and evolutionary diversity of plant MADS-domain factors: insights from recent studies

et al. 2012

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SummaryMembers of the MADS-box transcription factor family play essential roles in almost every developmental process in plants. Many MADS-box genes have conserved functions across the flowering plants, but some have acquired novel functions in specific species during evolution. The analyses of MADS-domain protein interactions and target genes have provided new insights into their molecular functions. Here, we review recent findings on MADS-box gene functions in Arabidopsis and discuss the evolutionary history and functional diversification of this gene family in plants. We also discuss possible mechanisms of action of MADS-domain proteins based on their interactions with chromatin-associated factors and other transcriptional regulators. Key words: MADS-box genes, Plant development, Evolution, Transcriptional regulationIntroduction MADS-domain transcription factors comprise one of the beststudied gene families in plants and members of this family play prominent roles in plant development. Two decades ago, the first MADS-box genes AGAMOUS (AG) from Arabidopsis thaliana (Yanofsky et al., 1990) and DEFICIENS (DEF) from Antirrhinum majus (Schwarz-Sommer et al., 1990) were discovered as regulators of floral organ identity. The sequence of the ~60 amino acid DNA-binding domains within these proteins showed striking similarities to that of the previously characterized proteins serum response factor (SRF) in Homo sapiens (Norman et al., 1988) and Minichromosome maintenance 1 (Mcm1) in Saccharomyces cerevisiae (Passmore et al., 1988). This shared and conserved domain was named the MADS domain (for MCM1, AG, DEF and SRF) and is present in all MADS-domain transcription factor family members (Schwarz-Sommer et al., 1990). Structural analysis of animal and yeast MADS domains showed that the N-terminal and central parts of the MADS domain make contacts with the DNA, while the C-terminal part of this domain contributes mainly to protein dimerization, resulting in a DNA-binding protein dimer consisting of two interacting MADS monomers (e.g. Pellegrini et al., 1995;Huang et al., 2000). Over the past 22 years, many MADS-box gene functions were uncovered in the model species Arabidopsis thaliana and in other flowering plants. Important model plant species for MADS-box gene research include snapdragon (Antirrhinum majus) (reviewed by Schwarz-Sommer et al., 2003), tomato (Solanum lycopersicum), petunia (Petunia hybrida) (Gerats and Vandenbussche, 2005), gerbera (Gerbera hybrida) (Teeri et al., 2006) and rice (Oryza sativa) (reviewed by Yoshida and Nagato, 2011).Initially, MADS-box genes were found to be major players in floral organ specification, but more recent studies revealed functions for MADS-box genes in the morphogenesis of almost all organs and throughout the plant life cycle, from embryo to gametophyte development. The MADS-box gene family in higher plants is significantly larger than that found in animals or fungi, with more than 100 genes in representative flowering plant Development 139, 3081-3098 (2012) REVIEW Box 1...

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Section: Transition To Floweringmentioning

confidence: 99%

Developmental and evolutionary diversity of plant MADS-domain factors: insights from recent studies

et al. 2012

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“…The best studied of these are the moss Physcomitrella patens and the thalloid liverwort M. polymorpha. Although both species show ample promise for bioengineering, Marchantia offers several unique advantages including a shorter life cycle, the production of gemmae as accessible and robust vegetative propagules (Shimamura 2012), a more streamlined genome (Sasaki et al 2007;Zobell et al 2010), and a simple spore-based transformation method for genetic manipulation.…”

Section: Marchantia As a Basal Model Chassis For Plant Synthetic Biologymentioning

confidence: 99%

Synthetic Botany

Boehm

Pollak

Purswani³

et al. 2017

Cold Spring Harb Perspect Biol

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Plants are attractive platforms for synthetic biology and metabolic engineering. Plants' modular and plastic body plans, capacity for photosynthesis, extensive secondary metabolism, and agronomic systems for large-scale production make them ideal targets for genetic reprogramming. However, efforts in this area have been constrained by slow growth, long life cycles, the requirement for specialized facilities, a paucity of efficient tools for genetic manipulation, and the complexity of multicellularity. There is a need for better experimental and theoretical frameworks to understand the way genetic networks, cellular populations, and tissue-wide physical processes interact at different scales. We highlight new approaches to the DNA-based manipulation of plants and the use of advanced quantitative imaging techniques in simple plant models such as Marchantia polymorpha. These offer the prospects of improved understanding of plant dynamics and new approaches to rational engineering of plant traits.

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“…Type II MADS-box genes radiated in land plants and formed two groups: the MIKC c and MIKC* [39]. MIKC* genes have retained a gametophyte function in bryophytes [40] and angiosperms [41]; conversely, MIKC c genes are expressed in both the gametophyte and sporophyte tissues in mosses and ferns [42][43][44], but are mostly restricted to the sporophyte in Arabidopsis, where they function as the most important floral homeotic genes [41]. This suggests that the MIKC c genes progressively acquired roles in sporophyte development during the evolution of vascular plants.…”

Section: Genes and The Evolution Of Plant Development (A) Sporophyte mentioning

confidence: 99%

Morphological evolution in land plants: new designs with old genes

Pires

Dolan

2012

Phil. Trans. R. Soc. B

204

189

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The colonization and radiation of multicellular plants on land that started over 470 Ma was one of the defining events in the history of this planet. For the first time, large amounts of primary productivity occurred on the continental surface, paving the way for the evolution of complex terrestrial ecosystems and altering global biogeochemical cycles; increased weathering of continental silicates and organic carbon burial resulted in a 90 per cent reduction in atmospheric carbon dioxide levels. The evolution of plants on land was itself characterized by a series of radical transformations of their body plans that included the formation of three-dimensional tissues, de novo evolution of a multicellular diploid sporophyte generation, evolution of multicellular meristems, and the development of specialized tissues and organ systems such as vasculature, roots, leaves, seeds and flowers. In this review, we discuss the evolution of the genes and developmental mechanisms that drove the explosion of plant morphologies on land. Recent studies indicate that many of the gene families which control development in extant plants were already present in the earliest land plants. This suggests that the evolution of novel morphologies was to a large degree driven by the reassembly and reuse of pre-existing genetic mechanisms.

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MIKC* MADS-Box Proteins: Conserved Regulators of the Gametophytic Generation of Land Plants

Cited by 72 publications

References 46 publications

Developmental and evolutionary diversity of plant MADS-domain factors: insights from recent studies

Developmental and evolutionary diversity of plant MADS-domain factors: insights from recent studies

Synthetic Botany

Morphological evolution in land plants: new designs with old genes

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