Miktoarm star polymers nanocarrier: synthesis, characterisation, and in-vitro drug release study

Chong, Yie Kie; Zainol, Ismail; Ng, Chew Hee; Ooi, Ing Hong

doi:10.1007/s10965-019-1726-4

Cited by 19 publications

(17 citation statements)

References 44 publications

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“…Consequently, the CMC can be found as a change in the intensity ratio of I 338 -I 339 /I 333 -I 336 in the excitation spectra [ 51 , 130 ]. Importantly, the CMCs attained in miktoarm star assemblies (10 −7 –10 −9 M) have generally been found to be lower than those of diblock copolymers (10 −4 –10 −7 M), though it should be noted that most diblock systems have CMCs closer to 10 −7 M [ 4 , 14 , 15 , 16 , 17 , 20 , 21 , 22 , 23 , 24 , 25 , 75 ]. Incorporation of additional arms in miktoarm star polymers allows for further stabilization of micelles, leading to lower CMCs.…”

Section: Amphiphilic Miktoarm Star Polymers: Self-assemblymentioning

confidence: 99%

“…This has been mainly a concern for diblock copolymers, and it can be lessened by making use of the branched architectures. For example, in a study of AB 2 (A = poly(lactide-co-glycolide) (PLGA), B = PEG) miktoarm stars, increasing the length of PLGA arms was shown to result in total cumulative ibuprofen release to be between 10 and 60% [ 75 ]. In another study (using AB 2 (A = PCL, B = PEG) miktoarm stars), nimodipine loading efficiencies, scaled between 23 and 70%, with variations in PCL length in PEG775 2 –PCL5800 and PEG775 2 –PCL19000.…”

Section: Amphiphilic Miktoarm Star Polymers: Self-assemblymentioning

confidence: 99%

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Miktoarm Star Polymers: Branched Architectures in Drug Delivery

Lotocki

Kakkar

2020

Pharmaceutics

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Delivering active pharmaceutical agents to disease sites using soft polymeric nanoparticles continues to be a topical area of research. It is becoming increasingly evident that the composition of amphiphilic macromolecules plays a significant role in developing efficient nanoformulations. Branched architectures with asymmetric polymeric arms emanating from a central core junction have provided a pivotal venue to tailor their key parameters. The build-up of miktoarm stars offers vast polymer arm tunability, aiding in the development of macromolecules with adjustable properties, and allows facile inclusion of endogenous stimulus-responsive entities. Miktoarm star-based micelles have been demonstrated to exhibit denser coronae, very low critical micelle concentrations, high drug loading contents, and sustained drug release profiles. With significant advances in chemical methodologies, synthetic articulation of miktoarm polymer architecture, and determination of their structure-property relationships, are now becoming streamlined. This is helping advance their implementation into formulating efficient therapeutic interventions. This review brings into focus the important discoveries in the syntheses of miktoarm stars of varied compositions, their aqueous self-assembly, and contributions their formulations are making in advancing the field of drug delivery.

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Section: Amphiphilic Miktoarm Star Polymers: Self-assemblymentioning

confidence: 99%

Section: Amphiphilic Miktoarm Star Polymers: Self-assemblymentioning

confidence: 99%

Miktoarm Star Polymers: Branched Architectures in Drug Delivery

Lotocki

Kakkar

2020

Pharmaceutics

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“…[ 10–13 ] In the light of the significant opportunities provided by these branched architectures in a diverse range of applications, there has been tremendous effort devoted to developing novel strategies for their construction, which can lead to better control of their overall composition. [ 16–22 ] These synthetic articulations will also continue to strengthen designing miktoarm star‐polymer based formulations with a desired combination of properties for efficient therapeutic interventions. [ 16,22–28 ]…”

Section: Introductionmentioning

confidence: 99%

Miktoarm Star Polymers with Environment‐Selective ROS/GSH Responsive Locations: From Modular Synthesis to Tuned Drug Release through Micellar Partial Corona Shedding and/or Core Disassembly

Lotocki

Yazdani

Zhang

et al. 2020

Macromolecular Bioscience

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Branched architectures with asymmetric polymeric arms provide an advantageous platform for the construction of tailored nanocarriers for therapeutic interventions. Simple and adaptable synthetic methodologies to amphiphilic miktoarm star polymers have been developed in which spatial location of reactive oxygen species (ROS) and glutathione (GSH) responsive entities is articulated to be on the corona shell surface or inside the core. The design of such architectures is facilitated through versatile building blocks and selected combinations of ring‐opening polymerization, Steglich esterification, and alkyne‐azide click reactions. Soft nanoparticles from aqueous self‐assembly of these stimuli responsive miktoarm stars have low critical micelle concentrations and high drug loading efficiencies. Partial corona shedding upon response to ROS is accompanied by an increase in drug release, without significant changes to overall micelle morphology. The location of the GSH responsive unit at the core leads to micelle disassembly and complete drug release. Curcumin loaded soft nanoparticles show higher efficiencies in preventing ROS generation in extracellular and cellular environments, and in ROS scavenging in human glioblastoma cells. The ease in synthetic elaboration and an understanding of structure‐property relationships in stimuli responsive nanoparticles offer a facile venue for well‐controlled drug delivery, based on the extra‐ and intracellular concentrations of ROS and GSH.

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“…Miktoarm polymers contain two or more polymeric units with various chemical structures. The miktoarm-block copolymers demonstrate exclusive phase-separation behavior either in solution or in bulk compared with linear-block copolymers due to the organization of the polymers, in which two constructional blocks are connected to a distinct confluence point [ 8 , 9 , 10 , 11 ]. This ability imparts miktoarm-block copolymers with wide potentials for use as nanocarriers of drugs compared with corresponding linear-block copolymers [ 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…To date, few reports have been published for the preparation of AB 2 -type miktoarm-block copolymers and their drug-delivery application [ 10 , 17 , 18 , 19 , 20 , 21 ]. Chong et al have reported the AB 2 -type miktoarm star polymers containing monomethoxy poly(ethylene glycol) (mPEG) and poly(D,L-lactide-co-glycolide) (PLGA) blocks and the general advantage of these miktoarm-block copolymers as nanocarriers for ibuprofen [ 10 ]. Yoon et al reported PEG–PCL 2 , and they investigated the self-aggregated structure, in vitro drug release using DOX and antitumor activities [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Doxorubicin-Loaded Amphiphilic Poly(D,L-Lactide-Co-Glycolide)-b-Poly(N-Acryloylmorpholine) AB2 Miktoarm Star Block Copolymers for Anticancer Drug Delivery

et al. 2020

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Owing to their unique topology and physical properties, micelles based on miktoarm amphiphilic star block copolymers play an important role in the biomedical field for drug delivery. Herein, we developed a series of AB2-type poly(D,L-lactide-co-glycolide)-b-poly(N-acryloyl morpholine) (PLGA-b-PNAM2) miktoarm star block copolymers by reversible addition–fragmentation chain–transfer polymerization and ring-opening copolymerization. The resulting miktoarm star polymers were investigated by 1H NMR spectroscopy and gel permeation chromatography. The critical micellar concentration value of the micelles increases with an increase in PNAM block length. As revealed by transmission electron microscopy and dynamic light scattering, the amphiphilic miktoarm star block copolymers can self-assemble to form spherical micellar aggregates in water. The anticancer drug doxorubicin (DOX) was encapsulated by polymeric micelles; the drug-loading efficiency and drug-loading content of the DOX-loaded micelles were 81.7% and 9.1%, respectively. Acidic environments triggered the dissociation of the polymeric micelles, which led to the more release of DOX in pH 6.4 than pH 7.4. The amphiphilic PLGA-b-PNAM2 miktoarm star block copolymers may have broad application as nanocarriers for controlled drug delivery.

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Miktoarm star polymers nanocarrier: synthesis, characterisation, and in-vitro drug release study

Cited by 19 publications

References 44 publications

Miktoarm Star Polymers: Branched Architectures in Drug Delivery

Miktoarm Star Polymers: Branched Architectures in Drug Delivery

Miktoarm Star Polymers with Environment‐Selective ROS/GSH Responsive Locations: From Modular Synthesis to Tuned Drug Release through Micellar Partial Corona Shedding and/or Core Disassembly

Preparation of Doxorubicin-Loaded Amphiphilic Poly(D,L-Lactide-Co-Glycolide)-b-Poly(N-Acryloylmorpholine) AB2 Miktoarm Star Block Copolymers for Anticancer Drug Delivery

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