English mobile learning platform is affected by external interference signals, resulting in poor remote transmission ability of English information. To solve this problem, a design of the English mobile learning platform based on the GSM-R wireless network communication system is proposed. The overall framework of the English mobile learning platform is designed. MSP430F149 single-chip microcomputer is selected as the hardware microcontrol unit of the platform, and R-C reset circuit is designed. The reset circuit is used to reset the single-chip microcomputer platform to prevent external signal interference. The modem is initialized according to AT instruction, and the main program flow of the single-chip microcomputer of the English mobile learning platform is designed on this basis. GSM-R wireless network communication system is used to plan the course module. After planning, the platform operation management function is designed, the interactive learning environment is established, the user information template is designed, and the platform database is built. The experimental results show that the designed English mobile learning platform can meet the learning needs and improve students’ comprehensive ability after application.