Mild allylic defluorination of 3,3-difluorobut-1-ene derivative activated by a phenylsulfonyl group

Palladium-Catalyzed Diversified Synthesis of Monofluorinated Alkenes from Allylic gem-Difluorides through Pd–OH Intermediate

“…These constraints underscore the crucial necessity for expanding the nucleophilic scope to enhance the versatility and applicability of these reactions. Here, a novel strategy has been developed, utilizing the F–Li interaction to generate the Pd–OH intermediate (Scheme B). With this Pd–OH intermediate, we achieved C–C bond formation by using diverse carbon nucleophiles.…”

Ring-Opening Diarylation of Siloxydifluorocyclopropanes by Ag(I) Catalysis: Stereoselective Construction of 2-Fluoroallylic Scaffold

“…In addition, miscellaneous methods have also been used to synthesize 2-fluoropropenes, for example, classical olefination reactions of carbonyl compounds with a proper fluorine-containing precursor, nucleophilic additions of fluoro-olefin substrates with aldehydes, and hydrofluorination of alkynes . Current investigations have emphasized efficient and stereoselective routes to fluoroalkenes in which metal-catalyzed C–F bond cleavage and allylic substitution of α,α-difluoroalkenes with nucleophiles have been recognized as an alternative representative to 2-fluoropropene target. , However, available examples still suffer from restricted substrate scope or limited reaction mode. Reliable and facile methods for stereoselective construction of the 2-fluoroallylic scaffold with diverse substituents are highly desired.…”