Mild Chemo-Photothermal Synergistic Therapy for Tumors Based on Gold-Nanoparticles Coupled with Metformin

Abstract

The past decades have witnessed great achievements in the synergistic therapy for tumors, especially chemo-photothermal synergistic therapy. However, due to the high working temperatures (>50 °C) of photothermal therapy, the peripheral tissue nearby tumors usually get burned, which limits the further clinical application of chemo-photothermal synergistic therapy. Thus, a mild chemo-photothermal synergistic therapy for tumor is eagerly awaited. Herein, a chemo-photothermal synergistic tumor therapy working under mild temperatures (43 °C) based on gold nanoparticles coupled with metformin was developed. In the 4T1-tumor bearing mice model, the tumor inhibition rate reached 94.6%. The interaction coefficient of this nano-conjugates was 0.2, indicating a high synergistic effect between chemoand photothermal therapy for tumors. Furthermore, pathological tests showed that the nanoconjugates prevent the tumor metastasis to the lung. Together with good targeting ability of tumor microenvironments and good biocompatibility, this work provides a potential drug candidate for the mild chemo-photothermal synergistic therapy for tumors.

POSS Engineering of Multifunctional Nanoplatforms for Chemo-Mild Photothermal Synergistic Therapy

“…Moreover, thermal images provided a more intuitive visualization of the temperature variations associated with POSS-SQ-DOX NPs (Figure 2e). In addition, significant chemosensitization effects occur when the tumor site temperature reaches 39.0-43.0 • C because, when the temperature is increased from 37.0 to 43.0 • C, the permeability of the cell membrane is significantly enhanced, which promotes the uptake of nano-drugs by cells [5]. Thus, a laser power of 0.5 W/cm 2 and a concentration of 50 µg/mL were selected for the following experiments.…”

“…To eradicate cancer cells through photo-thermal conversion, offering higher efficiency, minimal invasiveness, and fewer side effects [1][2][3][4][5][6][7][8][9][10][11][12]. However, it typically relies on local hyperthermia (above 50 • C) [13][14][15][16] for complete tumor ablation, which can result in damage to the surrounding healthy tissues, inflammation, and other undesirable biological effects during cancer treatments [17][18][19][20][21].…”

Supramolecular self-assembled gold nanoparticle clusters for synergistic photothermal-chemo tumor therapy

“…3,4 However, severe systemic toxicity, drug resistance, and poor selectivity of chemotherapy drugs, such as doxorubicin (DOX) and cisplatin, are the main obstacles limiting the chemotherapy efficacy. 5,6 Besides, considering the complexity, diversity, and heterogeneity of malignant tumors, monotherapy usually fails to achieve a satisfactory therapeutic effect. 7,8 Therefore, it is imperative to develop combination therapy that can synergize multiple treatment modalities to solve this dilemma.…”

Effects of Hydrophobic Gold Nanoparticles on Structure and Fluidity of SOPC Lipid Membranes

“…Due to their ability to absorb near-infrared light strongly at specific wavelengths and produce heat to destroy cancer cells, AuNP-mediated photothermal therapy (PTT) is an effective approach in cancer treatment [ 4 ]. Further, the AuNPs conjugated with anticancer drugs have the potential to produce a synergetic chemo-photothermal effect to drastically improve the therapeutic efficacy [ 5 ]. However, the extensive use of AuNPs in the biomedical field has raised serious concerns regarding their cytotoxic effects and impact on human health.…”