Mild Chronic Kidney Disease Associated with Greater Risk of Arterial Stiffness in Elderly Adults

Liu, I-Ting; Wu, Jin-Shang; Yang, Yi Ching; Huang, Ying; Lu, Feng-Hwa; Chang, Chih-Jen

doi:10.1111/jgs.12445

Cited by 10 publications

(11 citation statements)

References 31 publications

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“…It has been speculated that urinary NGAL in this population may reflect early chronic tubular damage that may be indicative of an increased mortality risk. Many previous studies have found that baPWV is related to both eGFR and chronic kidney disease (CKD) . The present study (Figure ) found that the mean baPWV differed significantly between eGFR tertiles in both the low and high urinary NAG groups.…”

Section: Discussionsupporting

confidence: 51%

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Association Between Pulse Wave Velocity and a Marker of Renal Tubular Damage (N‐Acetyl‐β‐D‐Glucosaminidase) in Patients Without Diabetes

Ouchi

Oba²,

Saigusa

et al. 2015

J of Clinical Hypertension

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The authors assessed the association between the ratio of urinary activity of N-acetyl-b-D-glucosaminidase (NAG) to creatinine and the brachial-ankle pulse wave velocity (baPWV) in patients without overt diabetes mellitus (DM). This was a cross-sectional study of 233 patients who had an estimated glomerular filtration rate (eGFR) ≥30 mL/min/ 1.73 m 2 and no history of kidney disease. Patients were divided into two groups: high NAG group (>5.8 U/g creatinine) and low NAG group (≤5.8 U/g creatinine). Mean baPWVs of the high NAG group were significantly higher than those of the low NAG group in both the eGFR ≥30 and <60 tertiles and the eGFR ≥60 and <90 tertiles. The baPWV was positively correlated with NAG in all patients (r=0.341, P<.001). Stepwise multivariate regression analysis showed that the baPWV was significantly related with NAG, age, and systolic blood pressure. Elevated NAG is related to elevated arterial stiffness in patients without DM.

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Section: Discussionsupporting

confidence: 51%

“…Age, hypertension, BP, and the white blood cell count have also been reported to be important correlates of greater baPWV . Heart rate and BMI have also been associated with baPWV .…”

Section: Discussionmentioning

confidence: 98%

Association Between Pulse Wave Velocity and a Marker of Renal Tubular Damage (N‐Acetyl‐β‐D‐Glucosaminidase) in Patients Without Diabetes

Ouchi

Oba²,

Saigusa

et al. 2015

J of Clinical Hypertension

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“…A series of studies reported that there was a linear association for renal impairment and arterial stiffness [21–25]. However, most of them did not address nonlinearity, and did not perform the subgroup analysis.…”

Section: Discussionmentioning

confidence: 99%

Estimated glomerular filtration rate and arterial stiffness in Japanese population: a secondary analysis based on a cross-sectional study

Yun-fen

Chen

2019

Lipids Health Dis

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Background Evidence regarding the relationship between estimated glomerular filtration rate (eGFR) and arterial stiffness is limited, and the data analysis is not sufficient to clarify the true relationship between the two. We aimed to investigate the relationship between eGFR and brachial-ankle pulse wave velocity (baPWV) in Japanese. Methods The present study was a cross-sectional study. Nine hundred twelve Japanese men and women, aging 24—84 years old, received a health medical check-up program including the results from baPWV inspection and various standardized questionnaires in a health examination center in Japan. The main outcome measures included eGFR, baPWV, fatty liver and postmenopausal status. Abdominal ultrasonography was used to diagnose fatty liver. Postmenopausal state was defined as beginning 1 year after the cessation of menses. Results The average age of the 912 selected participants was 51.5 ± 9.6 years old, and about 57.6% of them were male. The participants’ eGFR distribution was median 69.29 (min 39, max 122.28). The results of multivariate linear regression showed eGFR was not independently associated with baPWV after adjusting potential confounders (β = − 1.11, 95%CI -2.25 to 0.03), this is inconsistent with the result of eGFR (quartile) as a categorical variable (p for trend was 0.038). A non-linear relationship was detected between eGFR and baPWV, whose point was 77.05. The effect sizes and the confidence intervals of the left and right sides of inflection point were − 2.80 (− 4.41 to − 1.19) and 1.84 (− 0.50, 4.17), respectively. Subgroup analysis showed, the change in the elderly population is more pronounced (P for interaction = 0.018; − 2.83 with ≤60 year vs − 6.12 with > 60 year). The same trend was also seen in hypertensive people (P for interaction = 0.018; − 4.55 with hypertension vs − 0.82 with non-hypertension). Conclusion The relationship between eGFR and baPWV is non-linear. eGFR was negatively related to baPWV when eGFR is less than 77.05.

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“…Several mechanisms including those related to CKD have been suggested to be involved in accelerated vessel stiffening (3,8,(10)(11)(12)(13). Identified factors associated with increasing PWV in non-dialysed CKD patients are age, black ethnicity, male gender, hypertension and diabetes mellitus (13)(14)(15)(16). Evidence indicates that stiffening of the aorta may decrease in patients on maintenance dialysis (17).…”

Section: Introductionmentioning

confidence: 99%

Arterial stiffness in black African ancestry patients with chronic kidney disease living in Cameroon

Lemogoum

Halle

Mboule

et al. 2018

Cardiovasc. Diagn. Ther.

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Our findings suggest increased AS in Cameroonian CKD non-dialyzed as compared to dialyzed patients. Slower PWV in patients on maintenance hemodialysis suggests improvement of aortic distensibility following dialysis. However, further large-scale studies are needed to confirm our findings and to improve understanding of the underlying mechanisms of arterial stiffening in black African ancestry patients with CKD.

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Mild Chronic Kidney Disease Associated with Greater Risk of Arterial Stiffness in Elderly Adults

Abstract: Mild and moderate CKD increased the risk of greater arterial stiffness in elderly adults. Age, prediabetes mellitus, diabetes mellitus, prehypertension, and hypertension were also important correlates of increased arterial stiffness.

Cited by 10 publications

References 31 publications

Association Between Pulse Wave Velocity and a Marker of Renal Tubular Damage (N‐Acetyl‐β‐D‐Glucosaminidase) in Patients Without Diabetes

Association Between Pulse Wave Velocity and a Marker of Renal Tubular Damage (N‐Acetyl‐β‐D‐Glucosaminidase) in Patients Without Diabetes

Estimated glomerular filtration rate and arterial stiffness in Japanese population: a secondary analysis based on a cross-sectional study

Arterial stiffness in black African ancestry patients with chronic kidney disease living in Cameroon

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