Mild closed head injury in children compared to traumatic fractured bone; neurobehavioural sequelae in daily life 2 years after the accident

Abstract

Mild closed head injury in children compared to traumatic fractured bone: neurobehavioural sequelae in daily life 2 years after the accident Overweg-Plandsoen, W.C.G.; Kodde, A.; van Straaten, M.; van der Linden, E.A.M.; Neyens, L.G.J.; Aldenkamp, A.P.; Vermeulen, M. Published in: European Journal of Pediatrics Link to publication Citation for published version (APA):Overweg-Plandsoen, W. C. G., Kodde, A., van Straaten, M., van der Linden, E. A. M., Neyens, L. G. J., Aldenkamp, A. P., & Vermeulen, M. (1999). Mild closed head injury in children compared to traumatic fractured bone: neurobehavioural sequelae in daily life 2 years after the accident. European Journal of Pediatrics, 249-252. General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Abstract Two years after an accident resulting in either a mild head injury or a fractured bone, two groups of 22 children each, aged 4±14 years, were examined for the existence of any neurobehavioural symptoms by means of a standardized questionnaire ®lled out by their caretakers. Selection of the children was based on reports of the Accident and Emergency Department in 1 year. Signi®cantly more symptoms were reported after mild head injury. The main symptoms reported were headache, dizziness, fatigue and memory problems. The total number of symptoms in the children with mild head injury exceeded four times this in the group of children with a fractured bone. Conclusion Even 2 years after a mild head injury there are still residual symptoms in daily life. Key words Mild head injury á Fractured bone á Late sequelae á ChildrenAbbreviation CHI closed head injury IntroductionHead injury in children and young adults represents a signi®cant cause of morbidity and mortality. In 1990 in The Netherlands (population 15 millions), 2839 children aged 0±14 years were admitted to hospital because of a pedestrian/vehicle accident. A large percentage suered from head injury. The exact incidence of mild head injury in children is unknown. Children sustaining mild head injury usually are not admitted to hospital, however they are frequently seen for a short period of time on an outpatient basis, subsequently discharged and they never seek medical attention for the head injury again.Most head injuries in children are closed head injuries (CHI). A pro...

Tyrosinemia type 1: a rare and forgotten cause of reversible hypertrophic cardiomyopathy in infancy

“…However, CM associated with TT1 has been reported in a few studies [6-9], and Arora et al reported CM in six out of 20 patients with TT1 [6]. In agreement with our findings, Arora et al reported that cardiomyopathy associated with tyrosinemia was benign and was associated with a favorable outcome and complete resolution without recurrence in the vast majority of cases [6].…”

“…Similar to Case 1 in the present study, André et al reported the successful treatment of severe cardiomyopathy with NTBC in a patient with TT1 [8]. Furthermore, Mohan et al reported the complete resolution of cardiomyopathy in three patients with TT1 after liver transplantation [9]. However, in contrast with reports indicating a favorable prognosis of TT1-associated cardiomyopathy, data from the PCMR suggest that hypertrophic cardiomyopathy associated with inborn errors of metabolism carries a poorer prognosis [4].…”

“…This could be explained by the fact that most patients with inborn errors of metabolism included in the PCMR database had mitochondrial disorders, which are known to carry a poor prognosis, even in the absence of cardiomyopathy [4]. As seen in Case 1, the type of cardiomyopathy associated with TT1 is usually hypertrophic cardiomyopathy, predominantly involving hypertrophy of the interventricular septum [6-9]. It is interesting to note that most cases of TT1-associated cardiomyopathy are reported at the initial presentation of TT1, as in our first patient [6,7].…”

“…Cardiomyopathy is a rare condition in childhood [4], and the Pediatric Cardiomyopathy Registry (PCMR) estimated the incidence of childhood cardiomyopathy in the United States to be 1.13 cases per 100,000 children [4]. Cardiomyopathy may be the predominant finding in a number of inborn errors of metabolism, including mitochondrial disorders, glycogen storage disorders, carnitine transporter defects, fatty acid oxidation defects and lysosomal storage diseases [4,5], and some studies have reported cardiomyopathy as an unusual and rare manifestation of TT1 [6-9]. Herein we report two Saudi brothers with TT1.…”

Post-concussive symptoms in children with mild traumatic brain injury.

“…Relative to pre-injury status, uninjured children, or groups with other non-head trauma, children with mTBI are at increased risk for post-injury cognitive deficits, behavior problems, and post-concussive symptoms (PCS) (Asarnow, Satz, Light, Lewis, & Neumann, 1991; Kirkwood et al, 2008; Massagli et al, 2004; McKinlay, Dalrymple-Alford, Horwood, & Fergusson, 2002; Mittenberg, Miller, & Luis, 1997; Overweg-Plandsoen et al, 1999). PCS are especially prominent immediately after mTBI and include complaints of headache, dizziness, fatigue, depressed or anxious mood, sleep disturbance, light sensitivity, forgetfulness, and concentration difficulties.…”