Mild Cognitive Impairment and Dementia Show Contrasting Associations with Risk of Cancer

Willik, Kimberly D. van der; Ruiter, Rikje; Wolters, Frank J.; Ikram, M. Kamran; Stricker, Bruno H. Ch.; Hauptmann, Michael; Compter, Annette; Schagen, Sanne B.; Ikram, M. Arfan

doi:10.1159/000488892

Cited by 14 publications

(14 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a first attempt to do so, we investigated the risk of cancer in persons with MCI and compared this with the risk of cancer in dementia patients in a population-based prospective cohort study. 20 In this study, we showed that persons with MCI tended to have an increased risk of developing cancer VAN DER WILLIK ET AL. | 9 of 12 (HR 1.24, 95% CI 0.99-1.58), which is in contrast with the decreased cancer risk among patients with dementia (HR 0.59, 95% CI 0.41-0.68).…”

Section: Preclinical Stagesmentioning

confidence: 66%

“…Interestingly, multiple studies suggest an inverse association between cancer and dementia, in particular for Alzheimer disease (AD). [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] In 1990, Yamada et al investigated risk factors for dementia in atomic-bomb survivors and observed that the odds of having cancer prior to AD was 70% lower in patients with AD compared to persons without AD. More than a decade later, longitudinal studies confirmed that cancer patients were at a decreased risk of developing dementia.…”

Section: Dementia Patients and The Risk Of Dementia In Patients With mentioning

confidence: 99%

“…4 A substantial body of literature suggests a link between cancer and dementia, that is patients with dementia have a decreased risk of subsequently being diagnosed with cancer, and cancer patients have a lower risk of dementia. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Importantly, this association is not restricted to cancer of the central nervous system (CNS) or to long-term adverse effects of cancer treatments. Indeed, there is emerging evidence suggesting a direct link between non-CNS cancer and dementia.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cancer and dementia: Two sides of the same coin?

Willik

Schagen

Ikram

2018

Eur J Clin Investigation

View full text Add to dashboard Cite

Noncentral nervous system cancer and the brain share an interesting and complex relation, with an emerging body of evidence showing that cancer patients are at an increased risk of developing cognitive problems. In contrast, population‐based studies consistently find an inverse link between cancer and dementia, that is patients with dementia having a lower risk of subsequently developing cancer, and cancer patients being less often diagnosed with dementia. Different biological processes such as inversely activated cell proliferation and survival pathways have been suggested to have an important role underlying this inverse association. However, the effect of methodological biases including surveillance or survival bias has not been completely ruled out, calling into question the inverse direction of the association between cancer and dementia. In fact, emerging evidence now suggests that cancer and dementia might share a positive association. This narrative review summarises the current literature on cancer, cognitive problems and dementia. Moreover, different strategies will be discussed to reduce the impact of potential methodological biases on the association between cancer and dementia, trying to reveal the true direction of this link.

show abstract

Section: Preclinical Stagesmentioning

confidence: 66%

Section: Dementia Patients and The Risk Of Dementia In Patients With mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cancer and dementia: Two sides of the same coin?

Willik

Schagen

Ikram

2018

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

“…With regard to etiology, research has been done on diet [33][34][35][36] or lifestyle such as smoking [37,38] as a risk factor, and laboratory assessments, for example, inflammatory markers in association with cancer [31,[39][40][41]. Furthermore, the association between cognition and cancer was studied [42,43]. We have confirmed the positive association between a high baseline total cholesterol level and colorectal cancer (CRC) during follow-up, an association which was modified by dietary polyunsaturated fatty acids [35].…”

Section: Main Findings In the Last 3 Yearsmentioning

confidence: 99%

Objectives, design and main findings until 2020 from the Rotterdam Study

et al. 2020

View full text Add to dashboard Cite

The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical course, natural history and potential targets for intervention for chronic diseases in mid-life and late-life. The study focuses on cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1700 research articles and reports. This article provides an update on the rationale and design of the study. It also presents a summary of the major findings from the preceding 3 years and outlines developments for the coming period.

show abstract

“…Cancer and neurodegenerative disease, including AD as its most common form, may be seen as two opposite ends in cell proliferation. Yet they share biological and clinical characteristics, including dysregulations in key DNA repair and inflammation processes, an increasing incidence with advancing age, and rapid disease progression after diagnosis [6,7]. Moreover, they share a complex inheritance pattern with genetic pleiotropy [8].…”

Section: Introductionmentioning

confidence: 99%

Alzheimer’s disease as a multistage process: an analysis from a population-based cohort study

Licher

Willik

Vinke

et al. 2019

Aging

View full text Add to dashboard Cite

In cancer research, multistage models are used to assess the multistep process that leads to the onset of cancer. In view of biological and clinical similarities between cancer and dementia, we used these models to study Alzheimer’s disease (AD). From the population-based Rotterdam Study, we included 9,362 non-demented participants, of whom 1,124 developed AD during up to 26 years of follow-up. Under a multistage model, we regressed the logarithm of AD incidence rate against the logarithm of five-year age categories. The slope in this model reflects the number of steps (n–1) required for disease onset before the final step leading to disease manifestation. A linear relationship between log incidence rate and log age was observed, with a slope of 12.82 (95% confidence interval: 9.01-16.62), equivalent to 14 steps. We observed fewer steps for those at high genetically determined risk: 12 steps for APOE -ε4 carriers, and 10 steps for those at highest genetic risk based on APOE and a genetic risk score. The pathogenesis of AD complies with a multistage disease-model, requiring 14 steps before disease manifestation. Genetically predisposed individuals require fewer steps indicating that they already inherited multiple of these steps. Unravelling these steps in AD pathogenesis could benefit the development of intervention strategies.

show abstract

Mild Cognitive Impairment and Dementia Show Contrasting Associations with Risk of Cancer

Cited by 14 publications

References 28 publications

Cancer and dementia: Two sides of the same coin?

Cancer and dementia: Two sides of the same coin?

Objectives, design and main findings until 2020 from the Rotterdam Study

Alzheimer’s disease as a multistage process: an analysis from a population-based cohort study

Contact Info

Product

Resources

About