2021
DOI: 10.1093/function/zqab045
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Mild Cognitive Impairment and Donepezil Impact Mitochondrial Respiratory Capacity in Skeletal Muscle

Abstract: Alzheimer's Disease (ad) associates with insulin resistance and low aerobic capacity suggestive of impaired skeletal muscle mitochondrial function. However, direct measures of muscle mitochondrial function have not been performed in ad. This study (n = 50) compared skeletal muscle mitochondrial respiratory function and gene expression profiling in cognitively healthy older adults (CH; n = 24) to 26 individuals in the earliest phase of ad-related cognitive decline, mild cognitive impairment (MCI; n = 11) or MCI… Show more

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Cited by 15 publications
(28 citation statements)
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“…Although the connections between AD and sarcopenia are poorly understood, AD and musculoskeletal aging are associated with an overlapping set of differentially expressed genes that regulate mitochondrial function (Giannos et al, 2022). In addition, skeletal muscle mitochondria from individuals in the early phases of AD showed reduced respiratory kinetics and poor control of mitochondria coupling (Morris et al, 2021). Chronic neuroinflammation in AD correlates with reduced mitochondrial function in skeletal muscle, and our in silico analysis argues circulating IL-6 levels are increased in AD patients.…”
Section: Discussionmentioning
confidence: 99%
“…Although the connections between AD and sarcopenia are poorly understood, AD and musculoskeletal aging are associated with an overlapping set of differentially expressed genes that regulate mitochondrial function (Giannos et al, 2022). In addition, skeletal muscle mitochondria from individuals in the early phases of AD showed reduced respiratory kinetics and poor control of mitochondria coupling (Morris et al, 2021). Chronic neuroinflammation in AD correlates with reduced mitochondrial function in skeletal muscle, and our in silico analysis argues circulating IL-6 levels are increased in AD patients.…”
Section: Discussionmentioning
confidence: 99%
“…Morris et al sought to assess mitochondrial capacity in skeletal muscle of patients with early stages of cognitive decline and determine if respiratory function was associated with genetic risk (Apolipoprotein ε4; APOE4 ) or non-genetic risk factors (overweight/obesity, physical activity, and so on). 1 Mitochondrial respiratory capacity was assessed in fiber bundles from skeletal muscle biopsies from patients with mild-cognitive impairment (MCI, ( n = 11)) or MCI patients treated with donepezil (MCI + med, ( n = 15)) or cognitive healthy age-matched patients (CH, n = 24). Donepezil is a cholinesterase inhibitor that appears to improve memory and awareness and is prescribed to patients suffering from dementia.…”
Section: A Perspective On “Mild Cognitive Impairment and Donepezil Im...mentioning
confidence: 99%
“…MCI is the earliest clinical stage of ad , and represents a possible window for therapeutic intervention that could prevent or attenuate further symptom development. 1 Unfortunately, identification of ad in the earliest stages remains a challenge, thus making timing of an intervention more difficult. Thus, if patients with MCI or ad have a unique bioenergetic signature in their skeletal muscle tissue, it might be possible to use that as a biomarker for early identification of patients providing an improved window for therapeutic intervention.…”
Section: A Perspective On “Mild Cognitive Impairment and Donepezil Im...mentioning
confidence: 99%
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