Mild cognitive impairment and kidney disease: clinical aspects

Viggiano, D.; Wagner, Carsten A.; Bruchfeld, Annette; Fliser, Danilo; Fouque, Denis; Frische, Sebastian; Gesualdo, Loreto; Gutiérrez, Eugenio; Goumenos, Dimitrios; Hoorn, Ewout J.; Eckardt, Kai‐Uwe; Knauß, Samuel; König, Maximilian; Małyszko, Jolanta; Massy, Ziad A.; Nitsch, Dorothea; Pesce, Francesco; Rychlík, Ivan; Soler, María José; Spasovski, Goce; Stevens, Kate; Trepiccione, Francesco; Wanner, Christoph; Wiȩcek, Andrzej; Zoccali, Carmine; Unwin, Robert J.; Capasso, Giovambattista

doi:10.1093/ndt/gfz051

Cited by 56 publications

(57 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[ 4 ] obtained in four patients with CDI [ 4 ]. The relation between AVP and eGFR is further intriguing from the relationship that both have with cognitive functions [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Regulation of urinary calcium excretion by vasopressin

Anastasio

Trepiccione

Santo

et al. 2020

Clinical Kidney Journal

Self Cite

View full text Add to dashboard Cite

Background The antidiuretic hormone (ADH) or arginine vasopressin (AVP) regulates the body's water balance. Recently, modifications in AVP levels have been related to osteoporosis during ageing and microgravity/bed rest. Therefore the present study was devised to assess whether the absence of AVP, as in patients with central diabetes insipidus (CDI), modulates renal calcium excretion. Methods We retrospectively analysed data from 12 patients with CDI with measured 24-h urinary excretion levels of calcium. Data were available at the moment of the diagnosis when patients were drug-free and after therapy with dDAVP, an analog of AVP. Hypercalciuria was defined as 24-h urinary Ca2+ >275 mg/day in males and >250 mg/day in females and a urinary calcium (Ca):creatinine (Cr) ratio >0.20 mg/mg. Results Untreated CDI patients had a daily urinary Ca2+ excretion of 383 ± 47 mg/day and a urinary Ca:Cr ratio of 0.26 ± 0.38 mg/mg. The urine osmolarity significantly increased after the administration of dDAVP by 210% and the urinary flow decreased by 72%. Furthermore, the estimated glomerular filtration rate (eGFR) increased by 7%, which did not reach statistical significance. dDAVP treatment did not significantly modify the urinary Ca2+ concentration; however, the daily calcium excretion and the urinary Ca:Cr ratio were significantly decreased (160 ± 27 mg/day and 0.11 ± 0.02 mg/mg, respectively). Conclusions Patients with CDI show hypercalciuria even though urine is more diluted than normal controls, and dDAVP reverses this effect. These data support the intriguing relationship between AVP and osteoporosis in ageing and microgravity/bed rest.

show abstract

“…[ 4 ] obtained in four patients with CDI [ 4 ]. The relation between AVP and eGFR is further intriguing from the relationship that both have with cognitive functions [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Regulation of urinary calcium excretion by vasopressin

Anastasio

Trepiccione

Santo

et al. 2020

Clinical Kidney Journal

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the past decades, emerging evidence has indicated central nervous system involvement in DPN, and the association between cognitive impairment and DPN in diabetes had been reported [40][41][42]. It is suggested that dysregulation of glycemic control may lead to microvascular dysfunction in the blood-brain barrier, autoimmune damage to neurologic diseases, and changes in the synthesis, availability, or reuptake of neurotransmitters.…”

Section: Discussionmentioning

confidence: 99%

Thermal Perception Abnormalities Can Predict Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients

Fang

Chou

Sun

et al. 2020

Kidney Blood Press Res

View full text Add to dashboard Cite

Background: Previous studies have illustrated clinical associations between diabetic peripheral neuropathy (DPN) and diabetic kidney disease (DKD). Quantitative sensory testing (QST) can accurately detect thermal perception abnormalities and aid in the early diagnosis of asymptomatic small-fiber DPN in patients with type 2 diabetes. The aim of this study was to determine the predictive value of thermal perception abnormalities by QST to detect DKD. Methods: We prospectively enrolled 432 patients with type 2 diabetes (50.2% male, mean age 57.2 years, and average duration of diabetes 9.9 years) at our hospital between 2016 and 2017. Demographic and clinical data of the patients were recorded and analyzed. Diagnosis and staging of DKD were determined by urinary albumin excretion rate and estimated glomerular filtration rate. The presence of thermal perception abnormalities was determined by QST. Multiple logistic regression and receiver operating characteristic (ROC) analyses were performed to investigate the relationships between thermal perception abnormalities and DKD in these patients. Results: In multiple regression analysis, abnormal cold perception in the lower limbs was associated with an increased risk of advanced DKD. Area under the ROC curve analysis revealed that four-limb cold perception abnormalities had the best discriminatory power (0.741 ± 0.053) to predict advanced DKD. Conclusions: Our results demonstrate the value of using thermal perception abnormalities to identify patients with type 2 diabetes also at risk of DKD.

show abstract

“…As such, the strength of our conclusions may be limited without a valid measure of dietary intake and supplement use. Furthermore, Viggiano and colleagues recently suggested individuals with MCI and CKD may represent a distinct or extreme phenotype in comparison to those with MCI and no renal impairment in the general population 31 . The association between MCI and CKD is most evident in individuals with late CKD (stages 4 and 5) and in persons receiving chronic dialysis treatment 31 .…”

Section: Discussionmentioning

confidence: 99%

Serum xanthophyll carotenoids are associated with estimated glomerular filtration rate in an aged cohort

Browne

Williams

Maxwell

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Progressive renal decline is associated with increasing oxidative stress. However, the majority of studies have investigated endogenous antioxidants in predominantly advanced stages of kidney disease. Many traditional risk factors associated with renal dysfunction have been linked with cognitive decline as the kidneys and brain share comparable anatomic and haemodynamic characteristics that leave them susceptible to common pathogenic mechanisms. The objective of this study was to examine serum dietary antioxidants and their association with renal function characterised by estimated glomerular filtration rate (eGFR) in a cross-sectional analysis of 570 participants. High performance liquid chromatography quantified serum levels of retinol, α-tocopherol, γ-tocopherol and six carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lutein, lycopene and zeaxanthin) in participants. Multiple regression analyses were used to evaluate associations while adjusting for potential confounders. A sensitivity analysis was performed in cognitively-intact participants only. Serum levels of the xanthophyll carotenoid lutein were positively associated with eGFR in analyses adjusted for age (years), gender, smoking, APOE4 status and Alzheimer’s disease. Retinol was inversely associated with eGFR, although was no longer significant in the smaller sensitivity analysis. Our findings identify significant associations between the xanthophyll carotenoids and eGFR. Further investigations are required to confirm these findings.

show abstract

Mild cognitive impairment and kidney disease: clinical aspects

Cited by 56 publications

References 78 publications

Regulation of urinary calcium excretion by vasopressin

Regulation of urinary calcium excretion by vasopressin

Thermal Perception Abnormalities Can Predict Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients

Serum xanthophyll carotenoids are associated with estimated glomerular filtration rate in an aged cohort

Contact Info

Product

Resources

About