Mild cognitive impairment as a risk factor for Parkinson's disease dementia

Abstract

This is the first large international study evaluating the predictive validity of level II mild cognitive impairment criteria for PD. The results showed a clear and unique contribution of classification according to level II criteria to the hazard of PD dementia. This finding supports their predictive validity and shows that they contribute important new information on the hazard of dementia, beyond known demographic and PD-specific factors of influence. © 2017 International Parkinson and Movement Disorder Society.

The need for an extensive neuropsychological assessment for a reliable diagnosis of mild cognitive impairment in patients with Parkinson's disease

“…In our view, the pathophysiological and clinical heterogeneity of cognitive dysfunction in PD‐MCI, potentially affecting different cognitive domains and presenting sometimes in initial disease stages with subtle and selective cognitive deficits which can be appropriately assessed only with specific neuropsychological tasks, may explain why ‘global’ cognitive tools may not allow a reliable diagnosis of PD‐MCI. This viewpoint is in agreement with the conclusions of an MDS committee suggesting that ‘global’ cognitive scales in PD cannot be a substitute for comprehensive neuropsychological testing and with the results of a study of the MDS Study Group on the validation of PD‐MCI criteria , suggesting that the use of level 2 neuropsychological tools in the diagnosis of PD‐MCI has predictive validity in estimating the hazard of PD dementia. Since clinical trials aimed at treating cognitive dysfunction in PD at a pre‐dementia stage may become available soon, further efforts are needed in order to share universally accepted diagnostic tools and criteria for PD‐MCI for clinical and research purposes.…”

Prevalence and Clinical Aspects of Mild Cognitive Impairment in Parkinson's Disease: A Meta‐Analysis

“…Moreover, PD‐MCI resulted to be more frequent in PIGD and was associated with several demographic and disease‐related features. As PD‐MCI was also associated with a reduced QoL and higher levels of apathy and depression and could predict the development of dementia as confirmed by a recent meta‐analysis, it deserves to be detected early in clinical practice.…”

“…Mild cognitive impairment associated with Parkinson's disease (PD‐MCI) is a risk factor for the development of dementia associated with PD; thus, the early identification of patients with PD‐MCI in clinical routine might allow to deploy appropriate pharmacological and nonpharmacological interventions (ie, cognitive training). Until now, several prospective and cross‐sectional studies provided mixed data on the prevalence rate of PD‐MCI, ranging from about 20% to 70% .…”

Accuracy of Two Cognitive Screening Tools to Detect Mild Cognitive Impairment in Parkinson's Disease

“…These cognitive impairments affect quality of life, may result in caregiver distress, and are associated with nursing home admission . PD‐MCI patients have an increased risk of developing dementia compared to cognitively intact PD patients . Hence, it is essential to diagnose PD‐MCI in order to tailor clinical interventions, and hopefully in the future, to delay or prevent further cognitive decline.…”