Mild Cognitive Impairment: Potential Pharmacological Treatment Options

Sherwin, Barbara B.

doi:10.1111/j.1532-5415.2000.tb04703.x

Cited by 57 publications

(31 citation statements)

References 148 publications

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“…The community prevalence of MCI in older persons has been estimated to be as high as 38% [34]. A substantial fraction of these may also be executively impaired and would probably be classified as 'demented' (at least by DSM criteria) were clinicians aware of their ECF impairment and its effect on functional outcomes.…”

Section: Discussionmentioning

confidence: 99%

Misclassification Is Likely in the Assessment of Mild Cognitive Impairment

Royall

Chiodo

Polk³

2004

Neuroepidemiology

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We estimated the relative frequency of isolated memory impairment versus isolated and comorbid impairment in executive control function (ECF). One hundred and ninety-three noninstitutionalized residents of a single Comprehensive Care Retirement Community (mean age 79.2 years) were investigated. The subjects were tested with multiple measures of memory and ECF. Test scores were standardized to minimize scaling effects. ‘Impairment’ was defined as performance ≤1.5 standard deviations below the mean for the entire sample (i.e., a z score ≤–1.5). Disability was estimated as the sum of self-reported activities of daily living and instrumental activities of daily living. The cognitive test performance was significantly associated with functional impairment, independently of age. ECF and memory measures were significantly intercorrelated. Both were significantly and independently associated with disability ratings. 6–10% of the subjects had memory impairment; 25–35% of the memory-impaired subjects had comorbid ECF impairments. An additional 4–7% of the subjects had isolated ECF impairment. A significant fraction of the cases otherwise meeting the criteria for ‘mild cognitive impairment’ may have comorbid ECF impairment. This raises the issue of whether they might be more properly classified as ‘demented’. In addition, isolated ECF impairment may affect almost as many persons as isolated memory impairment. Isolated ECF impairment is not consistent with the natural history of preclinical Alzheimer’s disease, suggests other conditions, and can be disabling, independently of age and/or memory loss.

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Section: Discussionmentioning

confidence: 99%

Misclassification Is Likely in the Assessment of Mild Cognitive Impairment

Royall

Chiodo

Polk³

2004

Neuroepidemiology

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“…This phase has lately been termed mild cognitive impairment (MCI: Morris et al, 2000;Sherwin, 2000;Petersen et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Factors influencing intentions to seek a cognitive status examination: a study based on the Health Belief Model

Werner

2003

Int J Geriat Psychiatry

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“…MCI is currently considered a strategic intervention point in the clinical management of AD and, as a result, individuals with MCI are increasingly receiving pharmacologic interventions aimed at delaying or preventing progression to AD (Petersen & Morris, 2005;Sherwin, 2000).…”

Section: Introductionmentioning

confidence: 99%

Cognitive models of medical decision-making capacity in patients with mild cognitive impairment

Okonkwo

Griffith

Belue

et al. 2008

J. Inter. Neuropsych. Soc.

112

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This study investigated cognitive predictors of medical decision-making capacity (MDC) in patients with amnestic mild cognitive impairment (MCI). A total of 56 healthy controls, 60 patients with MCI, and 31 patients with mild Alzheimer's disease (AD) were administered the Capacity to Consent to Treatment Instrument (CCTI) and a neuropsychological test battery. The CCTI assesses MDC across four established treatment consent standards-S1 (expressing choice), S3 (appreciation), S4 (reasoning), and S5 (understanding)-and one experimental standard [S2] (reasonable choice). Scores on neuropsychological measures were correlated with scores on each CCTI standard. Significant bivariate correlates were subsequently entered into stepwise regression analyses to identity group-specific multivariable predictors of MDC across CCTI standards. Different multivariable cognitive models emerged across groups and consent standards. For the MCI group, measures of short-term verbal memory were key predictors of MDC for each of the three clinically relevant standards (S3, S4, and S5). Secondary predictors were measures of executive function. In contrast, in the mild AD group, measures tapping executive function and processing speed were primary predictors of S3, S4, and S5. MDC in patients with MCI is supported primarily by short-term verbal memory. The findings demonstrate the impact of amnestic deficits on MDC in patients with MCI. (JINS, 2008, 14, 297-308.)

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Mild Cognitive Impairment: Potential Pharmacological Treatment Options

Cited by 57 publications

References 148 publications

Misclassification Is Likely in the Assessment of Mild Cognitive Impairment

Misclassification Is Likely in the Assessment of Mild Cognitive Impairment

Factors influencing intentions to seek a cognitive status examination: a study based on the Health Belief Model

Cognitive models of medical decision-making capacity in patients with mild cognitive impairment

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