Mild cognitive impairment with Lewy bodies: blood perfusion with arterial spin labelling

Firbank, Michael; O’Brien, John; Durcan, Rory; Allan, Louise; Barker, Sally; Ciafone, Joanna; Donaghy, Paul C.; Hamilton, Calum A; Lawley, Sarah; Lloyd, Jim; Roberts, Gemma; Taylor, John‐Paul; Thomas, Alan

doi:10.1007/s00415-020-10271-1

Cited by 15 publications

(18 citation statements)

References 39 publications

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“…The disturbed information flow pattern in EMCI was consistent with previous evidence that the alterations in patients with dementia predominately involved DMN, ECN, SMN, and VN ( 15 , 19 , 30 , 31 ). The altered information flow pattern in cingulate, especially in posterior cingulate, was consistent with the functional deficit within DMN in patients with MCI and dementia ( 19 , 32 ), which may account for the episodic memory problems in EMCI ( 33 ).…”

Section: Discussionsupporting

confidence: 90%

“…Additionally, a good classification (accuracy of 80%) of EMCI and HC and good predictive abilities (r > 0.7) of the preferred information flow directions for the neurological state (cognitive measures and CSF biomarkers) were achieved. The disturbed information flow pattern in EMCI was consistent with previous evidence that the alterations in patients with dementia predominately involved DMN, ECN, SMN, and VN (15,19,30,31). The altered information flow pattern in cingulate, especially in posterior cingulate, was consistent with the functional deficit within DMN in patients with MCI and dementia (19,32), which may account for the episodic memory problems in EMCI (33).…”

Section: Discussionsupporting

confidence: 87%

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Information Flow Pattern in Early Mild Cognitive Impairment Patients

Ding

Jiang

et al. 2021

Front. Neurol.

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Purpose: To investigate the brain information flow pattern in patients with early mild cognitive impairment (EMCI) and explore its potential ability of differentiation and prediction for EMCI.Methods: In this study, 49 patients with EMCI and 40 age- and sex-matched healthy controls (HCs) with available resting-state functional MRI images and neurological measures [including the neuropsychological evaluation and cerebrospinal fluid (CSF) biomarkers] were included from the Alzheimer's Disease Neuroimaging Initiative. Functional MRI measures including preferred information flow direction between brain regions and preferred information flow index of each brain region parcellated by the Atlas of Intrinsic Connectivity of Homotopic Areas (AICHA) were calculated by using non-parametric multiplicative regression-Granger causality analysis (NPMR-GCA). Edge- and node-wise Student's t-test was conducted for between-group comparison. Support vector classification was performed to differentiate EMCI from HC. The least absolute shrinkage and selection operator (lasso) regression were used to evaluate the predictive ability of information flow measures for the neurological state.Results: Compared to HC, disturbed preferred information flow directions between brain regions involving default mode network (DMN), executive control network (ECN), somatomotor network (SMN), and visual network (VN) were observed in patients with EMCI. An altered preferred information flow index in several brain regions (including the thalamus, posterior cingulate, and precentral gyrus) was also observed. Classification accuracy of 80% for differentiating patients with EMCI from HC was achieved by using the preferred information flow directions. The preferred information flow directions have a good ability to predict memory and executive function, level of amyloid β, tau protein, and phosphorylated tau protein with the high Pearson's correlation coefficients (r > 0.7) between predictive and actual neurological measures.Conclusion: Patients with EMCI were presented with a disturbed brain information flow pattern, which could help clinicians to identify patients with EMCI and assess their neurological state.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

Information Flow Pattern in Early Mild Cognitive Impairment Patients

Ding

Jiang

et al. 2021

Front. Neurol.

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“…Data for participants without eye disease (Control) were taken from 19 healthy controls in previous studies investigating cognitive impairment ( Firbank et al, 2021 , Firbank et al, 2018 ). These were chosen to provide a good match of age and sex to the ED participants but with no significant loss of visual acuity or eye disease.…”

Section: Methodsmentioning

confidence: 99%

Investigation of structural brain changes in Charles Bonnet Syndrome

Firbank

Morgan

Collerton

et al. 2022

NeuroImage: Clinical

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“…All participants underwent detailed medical review and cognitive assessment, 13 and imaging 12,14,15 at baseline which have been previously reported, with further longitudinal review at approximately annual follow-ups.…”

Section: Designmentioning

confidence: 99%

Assessment of autonomic symptoms may assist with early identification of mild cognitive impairment with Lewy bodies

Hamilton

Frith

Donaghy

et al. 2022

Int J Geriat Psychiatry

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Objectives Autonomic symptoms are a common feature of the synucleinopathies, and may be a distinguishing feature of prodromal Lewy body disease. We aimed to assess whether the cognitive prodrome of dementia with Lewy bodies, mild cognitive impairment (MCI) with Lewy bodies (MCI‐LB), would have more severe reported autonomic symptoms than cognitively healthy older adults, with MCI due to Alzheimer's disease (MCI‐AD) also included for comparison. We also aimed to assess the utility of an autonomic symptom scale in differentiating MCI‐LB from MCI‐AD. Methods Ninety‐three individuals with MCI and 33 healthy controls were assessed with the Composite Autonomic Symptom Score 31‐item scale (COMPASS). Mild cognitive impairment patients also underwent detailed clinical assessment and differential classification of MCI‐AD or MCI‐LB according to current consensus criteria. Differences in overall COMPASS score and individual symptom sub‐scales were assessed, controlling for age. Results Age‐adjusted severity of overall autonomic symptomatology was greater in MCI‐LB (Ratio = 2.01, 95% CI: 1.37–2.96), with higher orthostatic intolerance and urinary symptom severity than controls, and greater risk of gastrointestinal and secretomotor symptoms. MCI‐AD did not have significantly higher autonomic symptom severity than controls overall. A cut‐off of 4/5 on the COMPASS was sensitive to MCI‐LB (92%) but not specific to this (42% specificity vs. MCI‐AD and 52% vs. healthy controls). Conclusions Mild cognitive impairment with Lewy bodies had greater autonomic symptom severity than normal ageing and MCI‐AD, but such autonomic symptoms are not a specific finding. The COMPASS‐31 may therefore have value as a sensitive screening test for early‐stage Lewy body disease.

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Mild cognitive impairment with Lewy bodies: blood perfusion with arterial spin labelling

Cited by 15 publications

References 39 publications

Information Flow Pattern in Early Mild Cognitive Impairment Patients

Information Flow Pattern in Early Mild Cognitive Impairment Patients

Investigation of structural brain changes in Charles Bonnet Syndrome

Assessment of autonomic symptoms may assist with early identification of mild cognitive impairment with Lewy bodies

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